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Jochen Steppan, M.D.

Photo of Dr. Jochen Steppan, M.D.

Assistant Professor of Anesthesiology and Critical Care Medicine

Male

Languages: English, French, German

Expertise: Anesthesiology

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-7519

Background

Dr. Jochen Steppan is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. He specializes in adult cardiothoracic anesthesiology. Dr. Steppan completed his M.D. at the Ruprecht Karls University in Heidelberg, Germany. He conducted residencies in anesthesiology at the UniversitDr. Jochen Steppan is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. He specializes in adult cardiothoracic anesthesiology.

Dr. Steppan completed his M.D. at the Ruprecht Karls University in Heidelberg, Germany. He conducted residencies in anesthesiology at the University Hospital of Heidelberg and the Johns Hopkins University School of Medicine. Additionally, he completed fellowships in anesthesiology and critical care medicine, adult cardiothoracic anesthesiology and pediatric cardiac anesthesiology at Johns Hopkins. His research focuses on vascular stiffness, an important predictor of aging associated cardio-vascular morbidity. Dr. Steppan is a member of the American Heart Association, the International Anesthesia Research Society, the American Society of Anesthesiologists, the Society for Cardiovascular Anesthesiologists and the German Medical Society for Acupuncture. He has published extensively and has won several awards for his research. He is certified by the American Board of Anesthesiology. y Hospital of Heidelberg and the Johns Hopkins University School of Medicine. Additionally, he completed fellowships in anesthesiology and critical care medicine, adult cardiothoracic anesthesiology and pediatric cardiac anesthesiology at Johns Hopkins.

His research focuses on vascular stiffness, an important predictor of aging associated cardio-vascular morbidity.

Dr. Steppan is a member of the American Heart Association, the International Anesthesia Research Society, the American Society of Anesthesiologists, the Society for Cardiovascular Anesthesiologists and the German Medical Society for Acupuncture. He has published extensively and has won several awards for his research. He is certified by the American Board of Anesthesiology.

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Titles

  • Assistant Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions

Education

Degrees

  • MD, Ruprecht Karls Universitat Heidelberg (2007)

Residencies

  • University Hospital of Heidelberg / Anesthesiology (2008)
  • Johns Hopkins University School of Medicine / Anesthesiology and Critical Care Medicine (2012)

Fellowships

  • Johns Hopkins University School of Medicine / Anesthesiology and Critical Care Medicine (2013)

Board Certifications

  • American Board of Anesthesiology / Anesthesiology (2013)

Research & Publications

Research Summary

Dr. Steppan’s research focuses on the basic science aspects of vascular stiffness, an important predictor of aging associated cardio-vascular morbidity.

In a collaborative effort with a team of cardiovascular biologists, he addresses important pathways of aging associated changes in nitric oxide signaling, the nitroso-redox milieu, endothelial function, extracellular matrix composition and vascular reactivity. The goal of these studies is not merely to characterize and describe the underlying basic vascular pathophysiology but to move those studies into the clinical realm to ultimately prevent, halt or even reverse aging associated vascular stiffness.

This approach has recently been awarded with a FAER Mentored Research Training Grant – Basic Science, to evaluate a novel target: LOXL2 (lysine-oxidase-like-2), which might be intimately involved in the development or progression of vascular stiffness. This study will advance the understanding of LOXL2's role in the vasculature, and might lead to the characterization of a novel therapeutic target, which is of critical importance for the treatment of cardiovascular diseases in the aging population.

Selected Publications

  1. Steppan J, Sikka G, Jandu S, Barodka V, Haluska MK, Flavahan N, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L. "Exercise, vascular stiffness, and tissue Transglutaminase." J Am Heart Assoc, 2014 Apr 10;3(2).
  2. Fitch ZW, Debesa O, Ohkuma R, Duquaine D, Steppan J, Schneider EB, Whitman GJ. "A protocol-driven approach to early extubation after heart surgery." J Thorac Cardiovasc Surg, 2014 Apr;147(4):1344-50.
  3. Sikka G, Pandey D, Bhuniya AK, Steppan J, Armstrong D, Santhanam L, Nyhan D, Berkowitz DE. "Contribution of arginase activation to vascular dysfunction in cigarette smoking." Atherosclerosis, 2013 Nov;231(1):91-4.
  4. Steppan J, Nyhan D, Berkowitz DE. "Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction." Front Immunol, 2013 Sep 17;4:278.
  5. Jung SM, Jandu S, Steppan J, Belkin A, An SS, Park A, Choi EY, Nyhan D, Butlin M, Viegas K, Avolio AP, Berkowitz DE, Santhanam L. "Increased Tissue Transglutaminase Activity Contributes to Central Vascular Stiffness in eNOS Knockout Mice." Am J Physiol Heart Circ Physiol, 2013 Sep 15;305(6):H803-10.

Activities & Honors

Honors

  • Research Award, Johns Hopkins Annual Research Day, 2011
  • Best Scientific Abstract, Maryland Society of Anesthesiologists, 2011
  • Best Abstracts of the Meeting: Anesthesiology Editor’s Picks, American Society of Anesthesiologists Annual Meeting, 2010
  • Best Scientific Abstract, Maryland Society of Anesthesiologists, 2010
  • Kosaka Award, International Anesthesia Research Society, 2009
  • German Acupuncture Award, best research study, 2006

Memberships

  • American Heart Association, 2004
  • American Society of Anesthesiologists, 2009
  • Deutsche Arztegesellschaft fur Akupunktur (German Medical Society for Acupuncture), 2006
  • European Society of Anaesthesiology, 2014
    Diplomate
  • International Anesthesia Research Society, 2009
  • Society for Cardiovascular Anesthesiologists, 2012
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