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Natalia A. Trayanova, M.S., Ph.D.

Photo of Dr. Natalia A. Trayanova, M.S., Ph.D.

Murray B. Sachs Professor

Joint Appointment in Medicine

Background

Titles

  • Murray B. Sachs Professor
  • Joint Appointment in Medicine

Departments / Divisions

Education

Degrees

  • M.S., Sofia University (Bulgaria) (1982)
  • Ph.D., Bulgarian Academy of Sciences - Sofia (Bulgaria) (1986)

Research & Publications

Research Summary

The mission of the Computational Cardiology Lab is to develop and exploit cutting-edge computational tools to advance the understanding of the fundamental mechanisms that underlie rhythm and contractile disorders in the heart and to develop better strategies for prevention and treatment of these disorders. The research in Dr. Trayanova’s Computational Cardiology Lab centers around understanding the normal and pathological electrophysiological and electromechanical behavior of the heart using multi-scale simulation approaches that include biophysically-detailed representations of cellular and subcellular processes and image-based descriptions of the geometry and structure of the heart. Research projects focus on the mechanisms for cardiac arrhythmogenesis and cardiac electromechanical interactions. Importantly, a large number of projects are devoted to the improvement of the clinical therapies of defibrillation, infarct-related ventricular ablation, and cardiac resynchronization therapy using a personalized approach. Research in Dr. Trayanova’s laboratory is supported by grants from NIH, NSF, and the American Heart Association.

Lab

Selected Publications

View all on Pubmed

  1. Vadakkumpadan F, Trayanova N, Wu KC. Image-based left ventricular shape analysis for sudden cardiac death risk stratification. Heart Rhythm. 2014 May 20. pii: S1547-5271(14)00549-9. doi: 10.1016/j.hrthm.2014.05.018. [Epub ahead of print] PMID: 24854217
  2. Trayanova NA, Rantner LJ. New insights into defibrillation of the heart from realistic simulation studies. Europace. 2014 May;16(5):705-13. doi: 10.1093/europace/eut330. PMID: 24798960 [PubMed - in process]
  3. Trayanova NA. Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management. Circ Res. 2014 Apr 25;114(9):1516-31. doi: 10.1161/CIRCRESAHA.114.302240. Review. PMID: 24763468
  4. Hu Y, Gurev V, Constantino J, Trayanova N. Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model. Heart Rhythm. 2014 Jun;11(6):1063-9. doi: 10.1016/j.hrthm.2014.03.021. Epub 2014 Mar 18. PMID: 24657430 [PubMed - in process]
  5. Boyle PM, Park CJ, Arevalo HJ, Vigmond EJ, Trayanova NA. Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles. PLoS One. 2014 Jan 28;9(1):e86947. doi: 10.1371/journal.pone.0086947. eCollection 2014. PMID: 24489810
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