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Photo of Dr. David R.M. Graham, M.S., Ph.D.

David R.M. Graham, M.S., Ph.D.

Executive Director, Center for Resources in Integrative Biology
Assistant Professor of Molecular and Comparative Pathobiology
Male

Titles

  • Executive Director, Center for Resources in Integrative Biology
  • Assistant Professor of Molecular and Comparative Pathobiology
  • Assistant Professor of Medicine

Centers & Institutes

  • Center for Resources in Integrative Biology
  • Institute for Basic Biomedical Sciences

Research Interests

H/SIV pathogenesis, and neuropathogenesis; Cardiovascular disease; High technology development

Biography

Dr. David R.M. Graham is an assistant professor of molecular and comparative biology at the Johns Hopkins University School of Medicine. He holds a secondary appointment in the Division of Cardiology. Additionally, he serves as the School of Medicine Executive Director for the Center for Resources in Integrative Biology, a School of Medicine and School of Public Health joint faculty initiative.

His research focuses on understanding the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions.

Dr. Graham completed his undergraduate studies in biomedical and health sciences at the University of Guelph and his master’s work in biology at McMaster University, both in Ontario, Canada. After a two-year break from academics, he relocated to Baltimore and returned to graduate school at Johns Hopkins, where he obtained his Ph.D. in biochemistry, cellular and molecular biology. In 2004, he joined the faculty of Johns Hopkins as a research associate in the Division of Cardiology, and in 2009 he became an assistant professor.

Dr. Graham is a member of several professional societies and serves on the editorial boards of PROTEOMICS and Frontiers Immunology. He has published more than two dozen peer reviewed articles and one book chapter, and has presented his work at several national and international conferences. . He has served as co-investigator or co-principal investigator on several research grants funded by the National Institutes of Health, and holds one patent.

Languages

  • English

Memberships

American Association for the Advancement of Science

American Society for Microbiologists

American Heart Association

Human Proteome Organization

Additional Resources +
  • Education +

    Education

    • Ph.D., The Johns Hopkins University School of Medicine, Baltimore, MD, 2004, Biochemistry, Cellular and Molecular Biology
    • M.Sc., McMaster University, Hamilton, Ontario, Canada, 1990, Biology
    • B.Sc., University of Guelph, Guelph, Ontario, Canada, 1990, Biomedical and Health Sciences

    Fellowships

    • The Johns Hopkins University School of Medicine, Baltimore, MD, 2006, Senior Research Fellow, Cardiology/Proteomics
  • Research & Publications +

    Research Summary

    Dr. Graham merges his research in cardiology and virology to study HIV-induced cardiomyopathy, an important emerging area in cardiovascular medicine.

    His research in virology is concentrated on understanding the differences between viruses with divergent pathologies, including the ability to differentially induce apoptosis by a IFN a/B induced expression of TRAIL, in collaboration with Gene Shearer (NIH) and Jean-Phillipe Herbeuval (Necker Institute, France), and viruses with the ability to induce neurotoxicity in collaboration with Drs. Zink and Clements (retrovirus laboratory).

    In cardiology, Dr. Graham focuses on the molecular phenotyping of transgenic rabbits over expressing alpha-myosin heavy chain, which has been shown to be cardioprotective against pacing induced heart failure. In this complex experimental model, Dr. Graham has been able to elucidate changes in the proteome caused by the transgene alone as compared to the background strain and differences between all groups under pacing induced heart failure. He has been collaborating on an investigation of the role of lipid rafts in the control of SA nodal cell function, and has developed ultra-sensitive mass-spectrometry methods to compare compositional changes in the lipid raft proteome between control and stimulated SA nodal cells.

    Selected Publications

    1. Brown, J.M., N.J. Shaw, and D.R. Graham. “The first five years: a mixed methods study investigating reflections on working as a hospital consultant.” JRSM Short Rep, 2013. 4(5): p. 2042533313476686.
    2. Linde, M.E., et al. “The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types.” J Proteome Res, 2013. 12(5): p. 2045-54.
    3. Nzowa, L.K., et al. “Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.” Fitoterapia, 2013. 87: p. 37-42.
    4. Tavano, B., et al. “Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes.” J Immunol, 2013. 190(6): p. 2622-30.
    5. Tovar, Y.R.L.B., et al. “Adenosine Triphosphate Released from HIV-Infected Macrophages Regulates Glutamatergic Tone and Dendritic Spine Density on Neurons.” J Neuroimmune Pharmacol, 2013.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Cellular and Molecular Medicine

  • Activities & Honors +

    Honors

    Travel Fellowship Award, 11th Conference on Retroviruses and Opportunistic Infections, 2004

    Travel Fellowship Award, 10th Conference on Retroviruses and Opportunistic Infections, 2003

    President’s Stock Option Award, Science Applications International Corporation, 1999 and 2000

    Professional Activities

    Editorial board member, PROTEOMICS

    Editorial board member, Frontiers Immunology

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Department/Division

    • Molecular and Comparative Pathobiology
    • Medicine - Cardiovascular

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