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Ying Liu, M.D., Ph.D.

Photo of Dr. Ying Liu, M.D., Ph.D.

Assistant Professor of Neurology

Research Interests: Peripheral neuropathy; Diabetic neuropathy; Chemotherapy-induced neuropathy; Autonomic neuropathy; Cardiac autonomic neuropathy

Contact for Research Inquiries

Rangos Building
855 N. Wolfe Street, Rangos Building, Room 292
Baltimore, MD 21205 map

Background

Dr. Ying Liu received her medical degree from China Medical University in China and completed her residency and then worked as an attending physician in Neurology at the Dalian Medical University. She received her PhD degree in Neuroscience field at the Yamaguchi University School of Medicine in Japan. After finishing her PhD program, she was promoted to Assistant Professor in the Department of Neuroscience in Japan. She also pursued additional clinical training in the Department of Neurology at the Juntendo University School of Medicine in Tokyo, Japan.  In order to broaden her exposure to transgenic models of neurodegenerative disease, she finished her postdoctoral fellow training in the Division of Neuropathology in Johns Hopkins University School of Medicine. Now as an assistant professor in the Cutaneous Nerve Laboratory of Neurology at Johns Hopkins, her focus is on evaluation of autonomic nerve fiber densities in skin biopsies and study the mechanism of fiber degeneration and regeneration in neurodegenerative disease.

Her expertise includes: Investigating the risk factors influencing autonomic fiber degeneration in human and experimental animal models. Understanding the mechanisms of neuropathy using genetic model systems. Developing the biomarker for Cardiac autonomic neuropathy and age-related neurodegenerative diseases. Studying the potential therapeutic strategy for diabetic neuropathy as well as chemo-therapy induced neuropathy.

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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • M.D., China Medical University (China) (1990)
  • Ph.D., Yamaguchi University School of Medicine (Japan) (2003)

Research & Publications

Research Summary

Dr. Liu's current research efforts include diabetic autonomic neuropathy, cardiac autonomic neuropathy and chemotherapy-induced autonomic neuropathy. Specific projects include combined analysis of autonomic neuropathy and sweat function test in diabetic transgenic animal models and chemotherapty-induced neuropathy animal models and evaluation the mechanism of neuropathy.

Technology Expertise Keywords

fiber degeneration and regeneration; neuropathy; autonomic neuropathy

Selected Publications

Liu Y, Billiet J, Ebenezer G, Pan B, Hauer P, Wei J, Polydefkis M, Factors influencing sweat gland innervation in diabetes. Neurology, 2015 April 21:84(16):1652-9

Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider B, and Lee MK. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. Journal of Neuroscience, 2012 Mar 7;32(10):3306-20. PMID: 22399753

Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Passive (Amyloid-B) Immunotherapy attenuates monoaminergic neurodegeneration in the AßPPswePS1dE9 Mice. Journal of Alzheimer`s Disease, 2011; 23(2): 271-9. PMID: 20966549. PMCID: PMC3063938

Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in transgenic mouse model of Alzheimer's disease. Journal of Neuroscience. 2008 Dec 17; 28(51):13805-14. PMID: 19091971

Liu Y, Kagechika H, Ishikawa J, Hirano H, Matsukuma S, Tanaka K, Nakamura S. Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. Journal of Neurochemistry. 2008 Aug; 106(3):1104-16. PMID: 18466335

Activities & Honors

Memberships

  • Peripheral Nerve Society
  • Society for Neuroscience

Videos & Media

Lectures and Presentations

  • Neuroprotective effects of Ethoxyquin in type II diabetic peripheral neuropathy
    Oral presentation , International Meeting , PNS Biennial Meeting of the Peripheral Nerve Society , Quebec, Canada (07/02/2015)
  • The innervation of human sweat glands and epidermis is reduced in diabetes and varies by gender and site, HbA1c, but not age.
    Poster presentation , International Meeting , The 5th World Congress on Controversies in Neurology (CONy) , Beijing, China (10/15/2011)
  • Alterations in skin epidermis in HIV associated sensory neuropathy.
    Poster presentation , International Meeting , The 5th World Congress on Controversies in Neurology (CONy) , Beijing, China (10/15/2011)
  • Cholinergic and noradrenergic innervation of human sweat glands is reduced in diabetes compared to control subjects and varies by gender and site, but not age
    Poster presentation , International Meeting , PNS Biennial Meeting of the Peripheral Nerve Society , Washington, DC (07/06/2011)
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