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Pablo A. Iglesias, Ph.D.

Photo of Dr. Pablo A. Iglesias, Ph.D.

Edward J. Schaefer Professor of Electrical Engineering, Johns Hopkins Whiting School of Engineering

Joint Appointment in Biomedical Engineering

Research Interests: Cellular biology; Cell motion; Cell division; Lipid homeostasis

Background

Dr. Pablo Iglesias holds joint appointments in biomedical engineering and in cell biology at the Johns Hopkins University School of Medicine. He is the Edward J. Schaefer Professor of Electrical Engineering at the Johns Hopkins Whiting School of Engineering, where he also holds an appointment in applied mathematics and statistics. 

His research focuses on cell biology, specifically cell movement and control. His team is currently engaged in exploring biological signal transduction pathways.

Dr. Iglesias received his B.A.Sc. in engineering science from the University of Toronto in 1987 and his Ph.D. in control engineering from Cambridge University in 1991. Since then, he has been on the faculty of the Johns Hopkins University. 

He has had visiting appointments at Lund University (automatic control), The Weizmann Institute of Science (mathematics) and the California Institute of Technology (control and dynamical systems). He also spent the 2012-2013 academic year on sabbatical at the Max-Planck Institute for the Physics of Complex Systems in Dresden. 

Dr. Iglesias has authored numerous research articles as well as two books: Minimum Entropy Control for Time-Varying Systems (Birkhäuser) and Control Theory and Systems Biology (MIT Press). He has received a number of awards for both research (the Charles E. Ives Best Paper Award for the Journal of Imaging Technology) and teaching (the George E. Owen Teaching Award at Johns Hopkins University). He was also named a distinguished lecturer for the IEEE Control Systems Society.

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Titles

  • Edward J. Schaefer Professor of Electrical Engineering, Johns Hopkins Whiting School of Engineering
  • Joint Appointment in Biomedical Engineering
  • Joint Appointment in Cell Biology

Education

Degrees

  • Ph.D., Cambridge University (United Kingdom) (1991)

Research & Publications

Research Summary

Dr. Iglesias’ research uses control and information theory to study biological signal transduction pathways. His research interests include understanding how cells interpret directional cues to guide cell motion, the regulatory mechanisms that control cell division, and the sensing and actuation that enable cells to maintain lipid homeostasis.

Lab Website: Cellular Signaling Control Laboratory

Selected Publications

Shi C, Channels WE, Zheng Y, Iglesias PA. "A computational model for the formation of lamin-B mitotic spindle envelope and matrix." Interface Focus. 2014 June;4(3):20130063.

Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN. "Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer." Science. 2014 March;343(6177):1249531.

Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. "An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration." Nature Cell Biology. 2013 Nov;15(11):1307-1316.

Luo T, Mohan K, Iglesias PA, Robinson DN. "Molecular mechanisms of cellular mechanosensing." Nature Materials. 2013 Nov;12(11):1064-1071.

Shi C, Iglesias PA. "Excitable behavior in amoeboid chemotaxis." Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2013 Sept;5(5):631-642.

Shi C, Huang CH, Devreotes PN, Iglesias PA. "Interaction of motility, directional sensing and polarity modules recreates the behaviors of chemotaxing cells." PLoS Computational Biology. 2013 July;9(7):e1003122.

Iglesias PA. "Systems biology: The role of engineering in the reverse engineering of biological signaling." Cells. 2013 May;2(2):393-413.

Zheng Y, Iglesias PA. "Nucleating new branches from old." Cell. 2013 Feb;152(4):669-670.

Robinson DN, Iglesias PA. "Bringing the physical sciences into your cell biology research." Molecular Biology of the Cell. 2012 Nov;23(21):4167-4170.

Porter JR, Lee C-YS, Espenshade PJ, Iglesias PA. "Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation." Molecular Biology of the Cell. 2012 Sept;23(18):3764-3774.

Activities & Honors

Honors

  • Charles E. Ives Best Paper Award, Journal of Imaging Technology
  • George E. Owen Teaching Award, Johns Hopkins University
  • Distinguished Lecturer, IEEE Control Systems Society
  • Science Spectrum Trailblazer, Science Spectrum Magazine, 2006

Memberships

  • American Society for Cell Biology
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