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Ming-Tseh Lin, M.D., Ph.D.
Director, Molecular Diagnostics Laboratory, Department of Pathology
Assistant Professor of Pathology
Languages: English, Chinese
Research Interests: Internal tandem duplication of the human genome; Next-generation sequencing (NGS) platforms; Cancer biomarkers; Molecular diagnosis of solid tumors ...read more
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The Johns Hopkins Hospital
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Dr. Ming-Tseh Lin is an assistant professor of pathology at the Johns Hopkins University School of Medicine and serves as the director of the Department of Pathology’s Molecular Diagnostics Laboratory.
A molecular pathologist, Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.
Because he initially practiced as a hematologist and bone-marrow transplant specialist, Dr. Lin has a unique perspective on molecular diagnostics.
Dr. Lin earned his medical and doctoral degrees at National Taiwan University Medical School and Hospital (Taipei), where he trained in internal medicine and hematology. He completed pathology residencies at The Johns Hopkins Hospital and Albany Medical College, as well as two pathology fellowships at Hopkins.
Dr. Lin has published more than 30 academic journal articles. He is certified in molecular genetic pathology and anatomic pathology by the American Board of Pathology.
- Director, Molecular Diagnostics Laboratory, Department of Pathology
- Assistant Professor of Pathology
- MD, National Taiwan University Medical School (1984)
- National Taiwan University Hospital / Internal Medicine (1991)
- Albany Medical College / Pathology (2006)
- Johns Hopkins University School of Medicine / Pathology (2009)
- National Taiwan University Hospital / Hematology (1991)
- Johns Hopkins University School of Medicine / Pathology (2008)
- Johns Hopkins University School of Medicine / Pathology (2010)
- American Board of Pathology / Anatomic Pathology (2009)
- American Board of Pathology / Molecular Genetic Pathology (2011)
Research & Publications
Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.
His current research aims to identify cancer biomarkers and design novel tandem-duplication PCR assays.
These assays will enable the detection of minimal residual disease (FLT/ITD AML) and explore the mechanisms for internal tandem duplication of the human genome.
In addition, investigators in the CLIA-certified Molecular Diagnostics Laboratory led by Dr. Lin have validated the NGS platform for mutation detection of formalin-fixed, paraffin-embedded neoplastic tissues.
Dr. Lin has previously studied the association between single- nucleotide polymorphisms and the outcomes of patients who underwent hematopoietic cell transplantation.
Selected PublicationsView all on Pubmed
- Lin MT, Mosier SL, Thiess M, Beierl KF, Debeljak M, Tseng LH, Chen G, Yegnasubramanian S, Ho H, Cope L, Wheelan SJ, Gocke CD, Eshleman JR. "Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing." Am J Clin Pathol. 2014 Jun;141(6):856-66. doi:10.1309/AJCPMWGWGO34EGOD.
- Olson MT, Harrington C, Beierl K, Chen G, Thiess M, O'Neill A, Taube JM, Zeiger MA, Lin MT, Eshleman JR. "BRAF pyrosequencing analysis aided by a lookup table." Am J Clin Pathol. 2014 May;141(5):639-47. doi: 10.1309/AJCPVWH1K2ZIHHTV.
- Dudley JC, Gurda GT, Tseng LH, Anderson DA, Chen G, Taube JM, Gocke CD, Eshleman JR, Lin MT. "Tumor Cellularity as a Quality Assurance Measure for Accurate Clinical Detection of BRAF Mutations in Melanoma." Mol Diagn Ther. 2014 Mar 7. [Epub ahead of print]
- Tseng LH, Tang JL, Haley L, Beierl K, Gocke CD, Eshleman JR, Lin MT. "Microsatellite Instability Confounds Engraftment Analysis of Hematopoietic Stem-cell Transplantation." Diagn Mol Pathol. 2014 Feb 24. [Epub ahead of print]
- Robertson S, Hyder O, Dodson R, Nayar SK, Poling J, Beierl K, Eshleman JR, Lin MT, Pawlik TM, Anders RA. "The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome." Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.