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Peter C. Searson, Ph.D.

Photo of Dr. Peter C. Searson, Ph.D.

Reynolds Professor of Engineering and Staff Investigator

Joint Appointment in Oncology

Research Interests: In vitro models of the tumor microenvironment for visualization of steps in the metastatic cascade and imaging drug/gene delivery ...read more

Background

Peter C. Searson is the Joseph R. and Lynn C. Reynolds Professor of Materials Science and Engineering. He directs the interdivisional Institute for NanoBioTechnology (INBT) launched in May 2006, which brings together researchers from medicine, engineering, the sciences, and public health to create knowledge and develop technologies to revolutionize health care and medicine. INBT has more than 190 affiliated faculty members. Searson has secondary appointments in the Johns Hopkins University Krieger School of Arts and Sciences Department of Physics and Astronomy and the Johns Hopkins Kimmel Cancer Center. Searson also served as director of the Johns Hopkins Center for Nanotechnology Excellence from 2009 to 2015.  His research interests include surface and molecular engineering and semiconductor quantum dots. His current research efforts focus on developing strategies to improve systemic delivery to a solid tumor by the enhanced permeability and retention effect, and developing in vitro models of the tumor microenvironment to visualize steps in the metastatic cascade. 

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Titles

  • Reynolds Professor of Engineering and Staff Investigator
  • Joint Appointment in Oncology

Departments / Divisions

Research & Publications

Selected Publications

M. E. Katt, A. L. Placone, A. D. Wong, Z. Xu,* and P. C. Searson, "In vitro tumor models: advantages, disadvantages, variables, and selecting the right platform," Frontiers in Bioengineering and Biotechnology – Tissue Eng. & Regen. Med., 4, e12 (2016). DOI: 10.3389/fbioe.2016.00012.

C. M. Dawidczyk, L. M. Russell, Peter C. Searson, "Perspective: Recommendations for benchmarking pre-clinical studies of nanomedicines," Cancer Research 75, 4016-4020 (2015). doi: 10.1158/0008-5472.CAN-15-1558. PMID: 26249177

A. D. Wong and P. C. Searson, "Live-cell imaging of invasion and intravasation in an artificial microvessel platform," Cancer Research 74, 4937-4945 (2014). DOI: 10.1158/0008-5472.CAN-14-1042. PMCID: 4132889

C. M. Dawidczyk, C. Kim, J. H. Park, L. Russell, K. H. Lee, M. G. Pomper, and P. C. Searson, "State-of-the-art in design rules for drug delivery platforms: lessons learned from FDA-approved nanomedicines," J. Controlled Release 187, 133–144 (2014). DOI: 10.1016/j.jconrel.2014.05.036. PMCID: 4155070. PMID: 24874289.

D. Wirtz, K. Konstantopoulos, and P. C. Searson, "The physics of cancer: the role of physical interactions and mechanical forces in metastasis," Nature Reviews Cancer 11, 512-522 (2011). doi:10.1038/nrc3080. PMCID: 3262453

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