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Jordan J. Green, Ph.D.

Photo of Dr. Jordan J. Green, Ph.D.

Director, Biomaterials and Drug Delivery Laboratory

Associate Professor of Biomedical Engineering

Research Interests: Developing biomaterials; stem cells; nanobiotechnology to meet challenges in regenerative medicine; ophthalmology; cancer

Background

Dr. Jordan J. Green is an Associate Professor of Biomedical Engineering, Ophthalmology, Oncology, Neurosurgery, and Materials Science & Engineering at the Johns Hopkins University School of Medicine. He is also an executive committee member of the Institute for NanoBioTechnology and co-founder of the Translational Tissue Engineering Center.

Dr. Green received his B.S. in chemical engineering and in biomedical engineering from Carnegie Mellon University in 2003 and completed his Ph.D. in biological engineering from the Massachusetts Institute of Technology in 2007. Subsequently, Dr. Green was a postdoctoral associate at MIT in chemical engineering from 2007-2008.

Dr. Green serves as the Chair of the Drug Delivery Special Interest Group of the Society For Biomaterials. He is also the CTO and co-founder of the Baltimore biotech startup company, AsclepiX Therapeutics. His work has resulted in the publication of over 70 papers and he has received numerous awards including the American Institute of Chemical Engineers Allan P. Colburn Award, the Biomedical Engineering Society Rita Schaffer Award, the American Society for Gene & Cell Therapy Outstanding New Investigator Award, the Tissue Engineering and Regenerative Medicine International Society Americas Young Investigator Award, the Presidential Early Career Award for Scientists and Engineers, and was named by Popular Science as one of the "Brilliant Ten."

Dr. Green's main research interests are in creating biomaterials and nanobiotechnology to develop advanced therapeutics. 

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Titles

  • Director, Biomaterials and Drug Delivery Laboratory
  • Associate Professor of Biomedical Engineering
  • Assistant Professor of Neurosurgery
  • Assistant Professor of Ophthalmology
  • Associate Professor of Oncology

Education

Degrees

  • B.S., Carnegie Mellon University (Pennsylvania) (2003)
  • Ph.D., Massachusetts Institute of Technology (Massachusetts) (2007)

Additional Training

Massachusetts Institute of Technology, Cambridge, MA, 2008, Chemical Engineering

Research & Publications

Research Summary

Dr. Green’s Biomaterials and Drug Delivery Laboratory (“Green Group”) focuses on the study of cellular engineering and in nanobiotechnology—particularly biomaterials, controlled drug delivery, stem cells, gene therapy and immunobioengineering.

The group examines the chemistry-biology-engineering interface to answer fundamental scientific questions – and to create innovative technologies and therapeutics that can directly benefit human health.

The goal is to better understand and control the therapeutic delivery of genetic material and drugs to cells.

His team is working to engineer biodegradable nanoparticles – often superior to viral delivery methods – that are efficiently delivered to be useful in drug release, gene therapy and new targeted treatments for cancer and eye diseases.

Current projects include: developing safe and effective biodegradable nanoparticles for DNA and siRNA delivery to treat cancer; developing polymeric microparticle-based biological treatments for age-related macular degeneration; designing biomimetic artificial antigen presenting cells for immunobioengineering; and enabling technologies for tissue engineering and regenerative medicine.

Lab Website: Green Group

Selected Publications

View all on Pubmed

Kozielski KL, Tzeng SY, Hurtado De Mendoza BA, Green JJ. "Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells." ACS Nano. 2014 Apr 3. [Epub ahead of print]

Bhise NS, Wahlin KJ, Zack DJ, Green JJ. "Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells." Int J Nanomedicine. 2013;8:4641-58. doi: 10.2147/IJN.S53830. Epub 2013 Dec 4.

Kim J, Sunshine JC, Green JJ. "Differential Polymer Structure Tunes Mechanism of Cellular Uptake and Transfection Routes of Poly(β-amino ester) Polyplexes in Human Breast Cancer Cells." Bioconjug Chem. 2013 Dec 20. [Epub ahead of print]

Bishop CJ, Kim J, Green JJ. "Biomolecule Delivery to Engineer the Cellular Microenvironment for Regenerative Medicine." Ann Biomed Eng. 2013 Oct 30. [Epub ahead of print]

Sunshine JC, Perica K, Schneck JP, Green JJ. "Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells." Biomaterials. 2014 Jan;35(1):269-77. doi: 10.1016/j.biomaterials.2013.09.050. Epub 2013 Oct 5.

Activities & Honors

Honors

  • Rita Schaffer Young Investigator Award, Biomedical Engineering Society, 2011
  • Recent Alumni Award, Carnegie Mellon University, 2012
  • Maryland Outstanding Young Engineer Award, 2012
  • Named one of the "Brilliant Ten", Popular Science, 2014
  • Presidential Early Career Award for Scientists and Engineers (PECASE 2013), 2016
  • Outstanding New Investigator Award, American Society for Gene and Cell Therapy (ASGCT), 2016
  • Allan P. Colburn Award for Excellence in Publications by a Young Member of the Institute, American Institute of Chemical Engineers (AIChE), 2016
  • America's Young Investigator Award, Tissue Engineering & Regenerative Medicine International Society (TERMIS), 2016
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