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Photo of Dr. Wenzhen Duan

Wenzhen Duan, M.D., M.S., Ph.D.

Director, Translational Neurobiology Laboratory
Associate Professor of Psychiatry and Behavioral Sciences
Female

Titles

  • Director, Translational Neurobiology Laboratory
  • Associate Professor of Psychiatry and Behavioral Sciences
  • Associate Professor of Neuroscience

Research Interests

biomarkers; Energy metabolism; Sirtuins; BDNF; Neutrotrophin; Parkinson''s disease; Huntington''s Disease; neurodegenerative disorders

Languages

  • English
Additional Resources +
  • Education +

    Education

    • M.D., Shanxi Medical University, Shanxi, PR China, 1992
    • Ph.D., Peking Union Medical University, Peking, PR China, 1998

    Fellowships

    • University of Kentucky, Lexington, Kentucky, 2000
  • Research & Publications +

    Research Summary

    Dr. Duan and her team use multidisciplinary approaches to elucidate molecular mechanisms and  develop therapeutic targets for Huntignton’s disease and Parkinson’s disease.

    Selected Publications

    1. Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, Mori S, Ross CA, Ye K and Duan W. Small molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington’s disease. Hum Mol Genet 2013, 22(12):2462-2470.
    2. Duan W. Sirtuins: from metabolic regulation to brain aging. Frontiers in Aging Neuroscience 2013, 5(36): 1-13
    3. Jin J, Cheng Y, Zhang Y, Wood W, Peng Q, Hutchison E, Mattson MP, Becker KG, Duan W. Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin. J Neurochem, 2012, 123(4): 477-90.
    4. Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA and Duan W. Trans-(-)-ε-viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMPK, and protects cells in models of Huntington’s disease. J. Bio Chem, 2012, 287(29):24460-72.
    5. Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenin T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KLK, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets. Nature Medicine, 2011, 18(1): 153-158.
    6. Cheng Y, Peng Q, Hou Z, Aggarwal M, Zhang J, Mori S, Ross CA, Duan W. Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington’s disease mouse model. Neuroimage, 2011, 56:1027-1034.
    7. Jiang M, Porat-Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, Li Q, Gillardon F, Hengerer B, Berlinicke C, Smith WW, Zack D, Poirier MA, Ross CA, Duan W.  Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.  J Neurochem, 2010, 114(2):419-29.
    8. Zhang J, Peng Q, Li Q, Jahanshad N, Hou Z, Jiang M, Masuda N, Langbehn DR, Miller MI, Mori S, Ross CA, Duan W. Longitudinal characterization of brain atrophy of a Huntington’s disease mouse model by automated morphological analyses of magnetic resonance images. Neuroimage, 2010, 49(3):2340-51.
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Department/Division

    • Psychiatry and Behavioral Sciences
    • Neuroscience

    For Research Inquiries Contact

    The Johns Hopkins Hospital
    CMSC 9-111
    600 N. Wolfe Street
    Baltimore, MD 21287

    Phone: 410-502-2866
    Fax: 410-614-0013

    E-mail: wduan2@jhmi.edu


    Administrative Assistant

    Lee Rorke
    E-mail : srorke1@jhmi.edu

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