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Laura DeLong Wood, M.D., Ph.D.

Photo of Dr. Laura DeLong Wood, M.D., Ph.D.

Assistant Professor of Pathology

Female

Expertise: Pathology

Research Interests: Cancer genomics; Pancreatic cancer; Premalignant precursor lesions

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-3511

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-3511

Contact for Research Inquiries

Wood Research Lab
1550 Orleans Street
CRB2 Room 345
Baltimore, MD 21231 map

Background

Dr. Laura DeLong Wood is an Assistant Professor of Pathology and Oncology at the Johns Hopkins University School of Medicine.

Dr. Wood received her B.S. in Biology from the College of William & Mary, graduating Summa Cum Laude with membership in Phi Beta Kappa. She then went on to earn both her M.D. and Ph.D. from The Johns Hopkins University School of Medicine, with membership in Alpha Omega Alpha. She completed her Ph.D. research in the laboratory of Dr. Bert Vogelstein, where she led the first whole exome sequencing studies in human cancers. Dr. Wood then went on to complete residency in Anatomic Pathology (serving as Chief Resident in her final year) and fellowship in Gastrointestinal and Liver Pathology at The Johns Hopkins Hospital. 

Her current research focuses on defining the key steps in malignant progression in the pancreas using next generation sequencing and other molecular biology approaches.

Dr. Wood is certified in Anatomic Pathology (AP) by the American Board of Pathology. She currently signs on clinical cases on the Gastrointestinal and Liver Pathology service.

For her research, Dr. Wood has been recognized as an AGA-Schwartz Pancreatic Cancer Research Scholar by the American Gastroenterological Association and a Kimmel Scholar from the Sidney Kimmel Foundation, and she received the AACR-Incyte Corporation Career Development Award for Pancreatic Cancer Research. Dr. Wood was also a member of the team from Johns Hopkins recognized by the American Association for Cancer Research with the Team Science Award.

 

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Titles

  • Assistant Professor of Pathology
  • Assistant Professor of Oncology

Education

Degrees

  • MD PhD, Johns Hopkins University School of Medicine (2009)

Residencies

  • The Johns Hopkins Hospital / Pathology (2012)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (2012)

Additional Training

  • Anatomic Pathology, American Board of Pathology (2012)

Research & Publications

Research Summary

Dr. Wood's research focuses on defining the key steps in malignant progression in the pancreas, and she has several exciting ongoing projects. Her group is working to define the molecular changes that underlie the “moment of invasion” in pancreatic cancer – this work will help to understand a key transition in the biology of pancreatic cancer and will also identify targets for early detection. In addition, she is developing an approach for genetic analyses of single pancreatic cancer cells in order to better define intratumoral heterogeneity. Finally, her group is developing a three-dimensional “organoid” model of pancreatic cancer in order to test the importance of potential biomarkers in living pancreatic cancer cells.

Selected Publications

View all on Pubmed

Wood LD*, Parsons DW*, Jones S*, Lin J*, Sjöblom T*, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JKV, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PVK, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B. The genomic landscapes of human breast and colorectal cancers. Science. 2007 Nov 16; 318(5853):1108-13. (*equal authorship)

Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr, Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011 Jul 20; 3(92):92ra66.

Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJA, Roa JC, Roberts LR, Gores GJ, Popescu I, Alexandrescu ST, Dima S, Fassan M, Simbolo M, Mafficini A, Capelli P, Lawlor RT, Ruzzenente A, Guglielmi A, TortoraG, de Braud F, Scarpa A, Jarnagin W, Klimstra D, Karchin R, Velculescu VE, Hruban RH, Vogelstein B, Kinzler KW, Papadopoulos N, Wood LD. Exome sequencing reveals frequent inactivating mutations in BAP1, ARID1A, and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet. 2013 Dec; 45(12):1470-3.

Dal Molin M, Zhang M, de Wilde RF, Ottenhof NA, Rezaee N, Wolfgang CL, Blackford AL, Vogelstein B, Kinzler KW, Papadopoulos N, Hruban RH, Maitra A, Wood LD. Very long-term survival following resection for pancreatic cancer is not explained by commonly mutated genes: results of whole-exome sequencing analysis. Clin Cancer Res. 2015 Apr 15; 21(8):1944-50.

Basturk O*, Hong SM*, Wood LD*, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LAA, Fukushima N, Goggins M, Hruban RH, Kato Y, Kern SE, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJA, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T. A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol. 2015 Dec; 39(12):1730-41. (*equal authorship)

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology

Activities & Honors

Honors

  • Team Science Award, American Association for Cancer Research
  • AGA-Bernard Lee Schwartz Foundation Research Scholar Award in Pancreatic Cancer, American Gastroenterological Association
  • Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research
  • AACR-Incyte Corporation Career Development Award in Pancreatic Cancer Research ?, American Association for Cancer Research
  • Phi Beta Kappa Honor Society
  • Alpha Omega Alpha Medical Honor Society

Memberships

  • American Association for Cancer Research
  • United States and Canadian Academy of Pathology
  • College of American Pathology
  • American Gastroenterological Association

Professional Activities

  • Abstract Review Board, United States and Canadian Academy of Pathology
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