My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
Clinical Trial Keywords:
Mild Cognitive Impairment (MCI), Functional neuroimaging, Memory impairment, Levetiracetam (Keppra)
Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474.
Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268.
Brandt, J., Bakker, A., & Aaron Maroof, D. (2010). Auditory confrontation naming in Alzheimer’s disease. The Clinical Neuropsychologist, 24,1326-1338.
Gallagher, M., Bakker, A., Yassa, M.A., & Stark, C.E.L. (2010). Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment. Current Alzheimer’s disease Research, 7, 197-199.
Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008). Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642.