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Pavan Bhargava, M.B.B.S., M.D.
Languages: English, Hindi
Expertise: Multiple Sclerosis
Dr. Bhargava developed an interest in immunology early in medical school at the Christian Medical College in Vellore, India. He then completed his neurology training at the Southern Illinois University School of Medicine and while there began research in the field of multiple sclerosis (MS). Following his neurology training he completed a 3-year fellowship at the Johns Hopkins University in neuroimmunology and neurological infections focusing on MS clinical care and research. His fellowship training was supported by a Sylvia Lawry physician fellowship award from the National MS Society.
His main research interests include studying the role of inflammation in the meninges in progression of MS disease. He is currently involved in a trial testing the utility of injecting a drug called rituximab into the spinal fluid in patients with progressive MS. He is also developing an animal model of the process of meningeal inflammation to test other potential treatments. This work is supported by awards from the National MS Society, Race to Erase MS and the American Academy of Neurology.
He is also actively involved in studying the role of measuring lipids and small molecule metabolites in serum and plasma to help identify new biomarkers for improved diagnosis and prognosis of the disease. These methods could also help in better tracking the effects of various interventions and in personalizing the treatment of patients with MS.
Departments / Divisions
- MBBS, Christian Medical College (2005)
- MD, Christian Medical College (2008)
- Christian Medical College / Internal Medicine (2008)
- Southern Illinois University School of Medicine / Neurology (2013)
- Johns Hopkins University School of Medicine / Neurology (2016)
- American Board of Psychiatry & Neurology / Neurology-General (2013, 2016)
Research & Publications
Selected PublicationsView all on Pubmed
Bhargava P, Calabresi PA. Metabolomics in Multiple Sclerosis. Mult Scler. 2016 Jan 11.
Sotirchos ES*, Bhargava P*, Eckstein C, Van Haren K, Baynes M, Ntranos A, Gocke A, Steinman L, Mowry EM, Calabresi PA. Safety and immunologic effects of high vs. low-dose cholecalciferol in multiple sclerosis. Neurology. 2015 Dec 30.
Saidha S, Al-Louzi O, Ratchford J, Bhargava P, Oh J, Newsome SD, Prince J, Pham D, Roy S, van Zijl P, Balcer LJ, Frohman EM, Reich DS, Crainiceanu C, Calabresi PA. Optical coherence tomography reflects brain atrophy in MS: A four-year study. Ann Neurol. 2015 Jul 18.
Bhargava P, Steele SU, Waubant E, Revirajan N, Marcus J, Dembele M, Cassard S, Hollis BW, Crainiceanu C, Mowry EM. Multiple Sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls. Mult Scler. 2015 Aug 18.
Bhargava P and Calabresi PA. Novel therapies for memory cells in autoimmune disease. Clin Exp Immunol. 2015 Jun;180(3):353-60.
Activities & Honors
- John F. Kurtzke Clinician Scientist Development Award, American Academy of Neurology, 2016
- Career Transition Award, National Multiple Sclerosis Society, 2016
- Sylvia Lawry Physician Fellowship Award, National Multiple Sclerosis Society, 2013 - 2015
- Neurology Writing Award, American Academy of Neurology, 2015