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Jacqueline Rachel Weissman, M.D., M.S.

Photo of Dr. Jacqueline Rachel Weissman, M.D., M.S.

Assistant Professor of Neurology

Background

Dr. Jaqueline Weissman is an assistant professor in the Department of Neurology, Kennedy Krieger Institute, Department of Pediatrics Johns Hopkins Hospital and Institute of Genomic Medicine at Johns Hopkins Hospital. She is also director of the Center for Tuberous Sclerosis and Related Disorder at Kennedy Krieger Institute.

She focuses on genetic and epigenetic causes of neurodevelopmental disorders - particularly intellectual disability - and how specific genetic and epigenetic changes lead to specific neuroanatomic, neurophysiologic and cognitive phenotypes. She is also interested in developing specific cognitive profiles in genetic syndromes as potential outcome measures for trials and to help localize deficits. Currently most of her research is centered around Kabuki Syndrome.

Dr. Weissman received her B.A. with Honors in English Language and Literature and Neurobiology from The University of Chicago. She earned an M.D. from Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and an M.S. in Clinical Research Scholars Program from Case Western Reserve University.

She completed a residency in pediatrics at the Children's Medical Center at UT Southwestern. 

Dr. Weissman was chief resident in the Neurodevelopmental Disabilities Program at Johns Hopkins through 2016. She is currently director of the Tuberous Sclerosis and Related Disorders Clinic, Neurogenetics attending, Neurology/Medical consultant to the KKI Neurobehavioral Unit and Kennedy Krieger Institute Rehabilitation Unit attending.

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Titles

  • Assistant Professor of Neurology
  • Assistant Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • M.S., Case Western Reserve University (Ohio) (2010)
  • M.D., Case Western Reserve University School of Medicine (Cleveland) (Ohio) (2010)

Research & Publications

Research Summary

I am interested in genetic and epigenetic causes of neurodevelopmental disorders - particularly intellectual disability - and how specific genetic and epigenetic changes lead to specific neuroanatomic, neurophysiologic and cognitive phenotypes. I am also interested in developing specific cognitive profiles in genetic syndromes as potential outcome measures for trials and to help localize deficits. Currently most of my research is centered around Kabuki Syndrome.

Clinical Trials

Neurodevelopmental disabilities, Neurogenetics, Intellectual disability

Selected Publications

Weissman JR, Kelley RI, Bauman ML, et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS One. 2008;3(11):e3815.

Bjornsson HT, Benjamin JS, Zhang L, Weissman J, et al. Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. SciTransl Med. 2014 Oct 1;6(256):256ra135

(RA) Weissman J, Naidu S, Bjornsson HT. Abnormalitics of the DNA methylation mark and its machinery: an emerging cause ofneurologicaldysfunction. Semin Neurol. 2014 Jul:34(3):249-57

BC Weissman J and Emrick L. Mitochondrial Disease. Chapter in Neurobiology of Disease, 2nd edition. In press.

Activities & Honors

Honors

  • 2007 Margaret L. Bauman Award for Excellence within the Autism Community, 2007 - 2008
  • Outstanding Student Researcher 2010 Public Health Poster Presentation Award, National Student Research Forum, 2010 - 2011
  • Award for Excellent Student in Medicine Clerkship and Excellent Student in Psychiatry Clerkship, 2010 - 2011
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