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Chuan-Hsiang Huang, M.D., Ph.D.

Photo of Dr. Chuan-Hsiang Huang, M.D., Ph.D.

Assistant Professor of Pathology

Background

Chuan-Hsiang (Bear) Huang, M.D., Ph.D., joined our faculty in Gynecologic Pathology in July 2016. Dr. Huang received his M.D. from National Taiwan University and completed two years of residency in internal medicine before joining the Graduate Program in Immunology here at Johns Hopkins.  His Ph.D. work, conducted in the labs of Mario Amzel and Bert Vogelstein, focused on structural studies of PI3Ka, one of the most frequently mutated proteins in human cancers and an important drug target. Using X-ray diffraction methods, Dr. Huang determined the first crystal structure of the PI3Ka heterodimer, elucidating the basis of PI3K over-activation in cancers.  To further understand the cellular biology of PI3K signaling, Dr. Huang conducted his postdoctoral research in the Devreotes lab, and studied the mechanism of cell migration and chemotaxis using Dictyostelium and human neutrophils as models. In collaboration with Pablo Iglesias, he combined single cell imaging with quantitative modeling to reveal the dynamic properties of the Ras-PI3K signaling network, how the network couples to the cytoskeleton during cell migration, and how chemotactic cues bias this coupling to guide movement. In his ongoing research, Dr. Huang is collaborating with Dr. TC Wu to extend these findings to the migration of cancer cells both in vitro and in vivo, and to understand the role of PI3K signaling in cancer metastasis from cellular to organismal levels.

Dr. Huang has numerous publications, including papers in Science, PNAS, and Nature Communications. He has received numerous awards, including the Silver Medal in the 33rd International Mathematical Olympiad, the Mette Strand Award, the Julian Baumert Thesis Award, and the Harold L. Plotnick Fellowship.

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Titles

  • Assistant Professor of Pathology

Departments / Divisions

Education

Degrees

  • M.D., National Taiwan University (Taiwan) (1999)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2009)
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