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Tian-Li Wang, Ph.D.

Photo of Dr. Tian-Li Wang, Ph.D.

Director of the Molecular Genetics Laboratory of Female Reproductive Cancer

Professor of Pathology

Research Interests: Cancer genetics; epigenomics; ovarian cancer; early detection of cancer; notch signaling; female reproductive cancer; cancer genomics; tumor modeling and chemo-prevention; molecular detection of uterine and ovarian cancer; next-generation tumor banking; chromatin remodeling and DNA damage in ovarian cancer ...read more

Contact for Research Inquiries

CRBII, Rm 306
1550 Orleans Street,
Baltimore, MD 21231 map

Background

Dr. Tian-Li Wang is the Professor of Pathology, Oncology, and Gynecology and Obstetrics at the Johns Hopkins University School of Medicine. She is the Director of the Molecular Genetics Laboratory of Female Reproductive Cancer and a senior member at the Breast and Ovarian Cancer Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. 

Dr. Wang earned her undergraduate degree from the National Taiwan University and received a Ph.D. degree from The Johns Hopkins University School of Medicine. She went on to a post-doc training in the retina neural circuity research area at the University of Pennsylvania and subsequently, completed her training in Cancer Genetics at the Howard Hughes Medical Institution at Johns Hopkins. 

Her current research interests are genomic and epigenomic studies of ovarian cancer, cancer detection and prevention, as well as new therapeutic strategies to overcome chemoresistance.

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Titles

  • Director of the Molecular Genetics Laboratory of Female Reproductive Cancer
  • Professor of Pathology
  • Professor of Gynecology and Obstetrics
  • Professor of Oncology

Centers & Institutes

Education

Degrees

  • B.S., National Taiwan University (Taiwan) (1989)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (1995)

Research & Publications

Research Summary

 Ovarian carcinoma is one of the most deadly neoplastic diseases among women; however, little is known about the molecular etiology of this disease. Dr. Wang’s research focuses on understanding genetic and epigenetic bases of this devastating disease and applying the knowledge onto develop new cancer diagnostics, prevention, and therapeutics. Dr. Wang has developed approaches to elucidate the genetic alterations at both DNA-sequence and copy-number levels, including high-throughput mutational detection and digital karyotyping, a technology that permits the identification of copy number alterations in cancer on a genome-wide scale with high resolution. Using both strategies, she has performed a comprehensive analysis of gynecologic malignancies and her team has identified several novel oncogenes and tumor suppressor genes in ovarian cancers. Her team is currently focusing on revealing the tumor-promoting functions of NOTCH3 signaling and tumor-suppressor functions of the ARID1A pathway. More recently, her team started to explore global epigenetic alterations and elucidating functional roles played by chromatin modifiers during tumor initiation and progression.

Lab Website: Gynecologic Pathology Laboratory

Selected Publications

Stoeck A, Jung J, Guan B, Wu R-C, Zhu H, Blackshaw S, Shih Ie, Wang TL. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Plos Genetics . Oct 30;10(10):e1004751. PMID: 25356737

Yuyu Fun, et al, Wang TL* and Shih IeM. Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell, Jul 13;28(1):82-96.
PMID: 2609684 *Corresponding author

Guan B, Suryo Rahmanto Y, Wu RC, Wang Y, Wang Z, Wang TL, Shih IeM. Roles of deletion of arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. J Natl Cancer Inst. 2014 Jun 4;106(7). PMID: 24899687 * Co-corresponding author

Jones S, Wang TL, Shih IeM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, LA Jr Diaz,Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 2010; 330(6001):228-31. PMID: 20826764

Wang TL, Maierhofer C, Speicher MR, Lengauer C, Vogelstein B, Kinzler KW, Velculescu VE. Digital Karyotyping. Proc Natl Acad Sci USA. 2002; 99:16156-16161

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology

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