For over two decades, my research has focused on the development and application of PET imaging methods to understand functional neuroanatomic and monoaminergic mechanisms associated with vulnerability to cognitive decline in late life, as well as to understand the mechanisms underlying the mood and cognitive responses to drug and brain stimulation treatment. In addition to the role of neuroimaging as a bridge between basic and clinical neuroscience, I appreciated early in my career that neuroimaging represents an unique opportunity to understand the earliest neurobiological changes that occur in cognitive and mood disorders in late life and to identify predictors of treatment response to infom the development of more effective treatments for mood and cognitive disorders. While the majority of this work has focused on geriatric depression, mild cognitive impairment and Alzheimer’s disease, the methods developed have been applied to other neuropsychiatric disorders including schizophrenia and traumatic brain injury
Laxton AW, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R, Wherrett J, Naglie G, Hamani C, Smith GS, Lozano AM. (2010) A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Annals of Neurology. 68(4):521-34
Diaconescu, A, Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., Smith, G. (2011) Distinct Functional Networks Associated with Improvement of Affective Symptoms and Cognitive Function During Citalopram Treatment in Geriatric Depression Human Brain Mapping, 32(10):1677-91
Smith, G., Workman, C., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D (2011) The acute cerebral metabolic response to citalopram is associated with the clinical response to citalopram treatmentAmerican Journal of Geriatric Psychiatry, 19(1):53-63.
Smith, G., Kahn, A., Sacher, J., Rusjan, P., Van Emiren, T., Flint, A., Wilson, A. (2011) Serotonin Transporter Occupancy and the Functional Neuroanatomic Effects of Citalopram Treatment in Geriatric Depression. American Journal of Geriatric Psychiatry, 19(12):1016-1025.
Smith GS, Laxton AW, Tang-Wai DF, McAndrews MP, Diaconescu, A., Workman, C, Lozano AM. (2012) Increased Cerebral Metabolism after One Year of Deep Brain Stimulation in Alzheimer’s Disease. Archives of Neurology, 69(9):1141-8.
Marano, C., Workman, C., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D, Smith G. (2013) Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. International Journal of Geriatric Psychiatry, 28(4):417-23
Lipsman N, Woodside DB, Giacobbe P, Hamani C, Carter JC, Norwood SJ, Sutandar K, Staab R, Elias G, Lyman CH, Smith GS, Lozano AM. (2013) Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial. Lancet, 381(9875):1361-70.
Marano CM, Workman CI, Lyman CH, Munro CA, Kraut MA, Smith GS. (2014) Structural Imaging in Late Life Depression: Association with Mood and Cognitive Responses to Antidepressant Treatment. American Journal of Geriatric Psychiatry. In press.