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School of Medicine
Lynne C. Jones, M.S., Ph.D.
Director, Center for Osteonecrosis Research and Education
Associate Professor of Orthopaedic Surgery
Research Interests: Osteonecrosis; Total Joint Replacement; Bone Graft and Bone Graft Substitutes; Animal models of musculoskeletal disease
Dr. Lynne Jones is an Associate Professor of the Department of Orthopaedic Surgery at the Johns Hopkins University. Her research focuses on the study of adult osteonecrosis and osteoarthritis, bone grafting and cell-based therapy, and factors influencing the long-term outcome of total joint replacement. Working in collaboration with orthopaedic surgeons, residents, and fellows, Dr. Jones is studying the role of bone marrow cells in the pathogenesis of osteonecrosis. The team is also evaluating cell-based therapy for this disorder. Furthermore, outcomes-based studies continue to evaluate the effect of biomaterials, surgical technique, and patient-related factors on the long-term outcome of total joint replacement.
Dr. Jones received her B.S. in Biology from Ursinus College, her M.S. in Biology (focus: endocrinology) from Towson State University and her Ph.D. in Molecular Microbiology and Immunology from the Johns Hopkins University. Since 1977, Dr. Jones have been engaged in orthopaedic research at the Johns Hopkins University regarding both basic and clinical science. In 1995, Dr. Jones was appointed the Director of the JHU Center for Osteonecrosis Research and Education. In 2013, she was appointed the JHU Director of Orthopaedic Resident Research.
Dr. Jones has authored over 100 peer-reviewed papers and 16 chapters. She has edited 2 books and 2 dedicated journal issues. She is a Past President of the Society For Biomaterials (2000) and the current President of ARCO International, a society dedicated to the study of bone circulation and its diseases. Dr. Jones is a Fellow of the International Union of Societies for Biomaterials Science & Engineering and a Fellow of the American Institute for Medical and Biological Engineering. In 2015, she received the Society For Biomaterials Award for Service. She has held a number of other leadership positions for the Orthopaedic Research Society, Society For Biomaterials, the National Osteonecrosis Foundation, and the Rocky Mountain Bioengineering Symposium.
- Director, Center for Osteonecrosis Research and Education
- Director of Resident Research
- Director, Hip & Knee Surgery Research
- Associate Professor of Orthopaedic Surgery
Departments / Divisions
- Orthopaedic Surgery - Orthopaedic Research
Centers & Institutes
- Metabolism and Obesity Research, Center for
- Osteonecrosis and Osteoporosis Research and Education, Center for
- B.S., Ursinus College (Pennsylvania) (1977)
- M.S., Towson University (Maryland) (1987)
- Ph.D., Johns Hopkins Bloomberg School of Public Health (Maryland) (1997)
Research & Publications
Dr. Jones’ research focuses on the pathogenesis and treatment of osteonecrosis. This involves an integration of both laboratory and clinical research to explore various risk factors as well as new treatments for this disorder. Using animal models developed in her laboratory, the effect of different external factors on bone physiology (intracapsular tamponade, corticosteroids, arterial and venous occlusion), the effectiveness of MRI as a diagnostic tool, and the potential of core decompression or BMP-7 as a treatment for osteonecrosis were studied. In clinical studies of osteonecrosis patients, their work reported that 82.2% of the patients had at least one coagulopathy compared to 30% of the controls (p < 0.0001); at least one coagulation factor abnormality was detected in all 5 idiopathic patients. In laboratory studies, her group found that corticosteroids altered gene and protein expression of key adipokines and that this has a negative effect on osteoblast proliferation and behavior.
Dr. Jones has studied various factors that influence the success or failure of total joint arthroplasty. Much of her laboratory work has utilized animal models of musculoskeletal disease, porous-coated implants and loosened orthopaedic implants. While observing that younger, more active patients fared well with cementless fixation of their implants, patient variables were identified which affected patient outcomes (HIV status, rheumatoid arthritis, morbid obesity, e.g.).
Selected PublicationsView all on Pubmed
Jones LC, Hungerford DS. Cement Disease. Clin Orthop Relat Res. 1987;225:192-206. PMID: 3315375
Jones LC, Mont MA, Le TB, Petri M, Hungerford DS, Wang P, Glueck CJ. Procoagulants and Osteonecrosis. J Rheumatol. 2003; 30 (4):783-91. PMID: 12672200
Wang D, Haile A, Jones LC. Dexamethasone-induced lipolysis increases the adverse effect of adipocytes on osteoblasts using cells derived from human mesenchymal stem cells. Bone. 2013 Apr; 53(2):520-30.
Johnson AJ, Mont MA, Tsao AK, Jones LC. "Treatment of femoral head osteonecrosis in the United States: 16-year analysis of the nationwide inpatient sample." Clin Orthop Relat Res. 2013 Aug 14.
Johnston JC, Haile A, Wang D, Jones LC. Dexamethasone treatment alters function of adipocytes from a mesenchymal stromal cell line. Biochem Biophys Res Commun. 2014; 451(4):473-479.
Jain A, Stein BE, Skolasky RL, Jones LC, Hungerford MW. Total joint arthroplasty in patients with rheumatoid arthritis: a United States experience from 1992 through 2005. J Arthroplasty. 2012 Jun;27(6):881-8.
Kane I, Naseer ZA, Jones LC, Khanuja HS, Sterling RS. Safety of tranexamic acid: Are any precautions needed? Tech Orthop. 2017;32(1):28-33.
Activities & Honors
- Fellow, International Union of Societies for Biomaterials Science & Engineering
- Fellow, American Institute for Medical and Biological Engineering
- Award for Service, Society for Biomaterials, 2015
- American Association of Orthopaedic Surgeons
- American Institute for Medical and Biological Engineering
- American Society for Bone and Mineral Research
- Hip Society
- Orthopaedic Research Society
- Rocky Mountain Bioengineering Symposium
- Ruth Jackson Orthopaedic Society
- Society for Biomaterials
- President, ARCO International
- Past President, Society for Biomaterials
- Executive Director, National Osteonecrosis Foundation
- Chair, Council of Societies, American Institute for Medical and Biological Engineering
- Chair, Advocacy Committee, Orthopaedic Research Society