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School of Medicine
Ryan Gregory Vandrey, Ph.D.
Associate Professor of Psychiatry and Behavioral Sciences
Research Interests: Human behavioral pharmacology of Cannabis (Marijuana); Nicotine/Tobacco
Dr. Vandrey’s research focuses on the behavioral pharmacology of cannabis (marijuana) and nicotine/tobacco. Dr. Vandrey conducted several laboratory studies demonstrating that a significant withdrawal syndrome occurs following abrupt cessation of heavy cannabis use. This included studies showing the time course of effects, the relative severity of cannabis withdrawal when compared with nicotine withdrawal, and the pharmacological specificity of the syndrome. Dr. Vandrey has also collaborated with toxicologists resulting in the publication of important papers helping to define the pharmacokinetics of cannabinoids in various biological matrices. He is currently conducting research exploring medications that can be used as adjuncts to behavior therapy to improve rates of abstinence among treatment seekers, examining the role of sleep in the development and maintenance of cannabis use disorders, conducting laboratory research on the pharmacokinetic and pharmacodynamic effects of cannabis across different routes of administration, and conducting research designed to help evaluate the safety and efficacy of medicinal use of cannabis. In addition to his work on cannabis, Dr. Vandrey has also conducted controlled research studies evaluating the mechanisms by which varenicline (Chantix®) helps smokers quit and been part of multi-site research projects evaluating the effects of nicotine dose reduction in cigarettes on smoking behavior. Dr. Vandrey also has experience in the study and application of contingency management (CM) and pay-for-performance (P4P) interventions for facilitating positive clinical outcomes for patients in outpatient treatment clinics.
- Associate Professor of Psychiatry and Behavioral Sciences
Centers & Institutes
- B.A., University of Delaware (Delaware) (1998)
- Ph.D., University of Vermont (Vermont) (2005)
Johns Hopkins University, Baltimore, MD, 2007
Research & Publications
I am interested in the human behavioral pharmacology of cannabis (marijuana) and nicotine/tobacco. My research focuses on the consequences of stopping heavy cannabis or tobacco use, the investigation of medications that can help improve success for individuals trying to quit, examining differences in pharmacokinetics and pharmacodynamics across different routes of administration, and studying novel research questions that emerge related to changes in policy. I also have interest in investigating novel ways to apply behavioral modification techniques to the treatment of drug abuse problems.
Budney, A.J., Hughes, J.R., Moore, B.A., & Vandrey, R.G. (2004). Review of the validity and significance of cannabis withdrawal syndrome. American Journal of Psychiatry, 161, 1967-1977.
Vandrey, R., Haney, M. (2009). Pharmacotherapy for Cannabis Dependence: How Close Are We? CNS Drugs, 23 (7), 1-11.
Vandrey, R., Smith, M.T., McCann, U.D., Budney, A.J., Curran, E.M. (2011). Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal. Drug and Alcohol Dependence, 117, 38-44.
Vandrey, R., Dunn, K.E., Fry, J.A., Girling, E.R. (2012). A survey study to characterize use of Spice products (synthetic cannabinoids). Drug and Alcohol Dependence, 120, 238-241.
Vandrey, R., Babson, K.A., Herrmann, E.S., Bonn-Miller, M.O. (2014). Interactions between Disordered Sleep, Post-Traumatic Stress Disorder, and Substance Use Disorders. International Review of Psychiatry, 26, 237-247.
Vandrey, R., Stitzer, M.L., Mintzer, M.Z., Huestis, M.A., Murray, J.A., Lee, D. (2013). The Dose Effects of Short-Term Dronabinol (Oral THC) Maintenance in Daily Cannabis Users. Drug and Alcohol Dependence, 128, 64-70.
Vandrey, R., Raber, J.C., Raber, M.E., Douglass, B., Miller, C., Bonn-Miller, M.O. (2015). Cannabinoid Dose and Label Accuracy In "Edible" Medical Cannabis Products. Journal of the American Medical Association, 313, 2491-2493.
Cone, E.J., Bigelow, G.E., Herrmann, E.S., Mitchell, J.M., LoDico, C., Flegal, R., Vandrey, R. (2015). Non-Smoker Exposure to Secondhand Cannabis Smoke I. Urine Screening and Confirmation Results. Journal of Analytical Toxicology, 39, 1-12.
Herrmann, E.S., Cone, E.J., Mitchell, J.M., Bigelow, G.E., LoDico, C., Flegal, R., Vandrey, R. (2015). Non-Smoker Exposure to Secondhand Cannabis Smoke II: Effect of Room Ventilation on the Physiological, Subjective, and Behavioral/Cognitive Effects. Drug and Alcohol Dependence, 151, 194-202.
Cone, E.J., Bigelow, G.E., Herrmann, E.S., Mitchell, J.M., LoDico, C., Flegal, R., Vandrey, R. (in press). Non-Smoker Exposure to Secondhand Cannabis Smoke III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects. Journal of Analytical Toxicology, 39, 497-509.
Videos & Media
Recent News Articles and Media Coverage
Hopes for Budding Medical Marijuana Industry High, Yet Hazy, WYPR, April 30, 2014