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Photo of Dr. Thomas Grader-Beck

Thomas Grader-Beck, M.D., Ph.D.

Assistant Professor of Medicine

Male  | Languages: English, French, German

Appointment Phone

443-997-1552

Main Location

Johns Hopkins Bayview Medical Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Assistant Professor of Medicine

Departments

Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 443-997-1552

Sjogrens Center
301 Mason Lord Drive
Baltimore, MD 21224 map
Phone: 410-550-1887

Johns Hopkins Bayview Medical Center

Appointment Phone: 443-997-1552

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-8089
Fax: 410-550-5601

Expertise

Rheumatology, Sjogren's Syndrome, Systemic Lupus Erythematosus

Research Interests

Pathogenesis of systemic autoimmune diseases, systemic lupus erythematosus and Sjogren''s

Biography

Dr. Grader-Beck is an Assistant Professor of Medicine in the Rheumatology Division. 

Dr. Grader-Beck’s clinical interests include systemic lupus erythematosus and Sjögren’s syndrome, with emphasis on complex patients that are difficult to treat, as well as patients with vaginal sicca.

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    Additional Information

  • Education +

    Degrees

    • Heidelberg University School of Medicine / MD (1997)

    Residencies

    • University of Massachusetts Medical Center / Internal Medicine (2003)

    Fellowships

    • Dana-Farber Cancer Institute (2000)
    • Johns Hopkins University School of Medicine / Rheumatology (2006)

    Certifications

    • American Board of Internal Medicine / Internal Medicine (2003, 2016)
  • Research & Publications +

    Research Summary

    His research interests include systemic lupus erythematosus and Sjögren’s syndrome. The pathogenesis of SLE and Sjogren’s syndrome, two closely related and common systemic autoimmune diseases, remains unknown. Antibodies that target self-molecules (autoantibodies) are thought to play an important role in the disease process. Dr. Grader-Beck’s laboratory is investigating mechanisms that may render self-structures immunogenic and hypothesizes that specific posttranslational modifications of antigens that may occur during infections or malignant transformation lead to expression of neoepitopes that propagate autoimmunity in the right setting. By combining studies using a variety of mouse strains, specific gene-deficient mice as well as human biological specimens, Dr. Grader-Beck’s team is taking a translational approach to answer these questions.

    Selected Publications

    Mathews PM, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer AN, Akpek
    EK. Ocular Complications of Primary Sjögren Syndrome in Men. Am J Ophthalmol.
    2015 Sep;160(3):447-452.e1. doi: 10.1016/j.ajo.2015.06.004. Epub 2015 Jun 17.
    PubMed PMID: 26093285.

    Akpek EK, Mathews P, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer
    AN. Ocular and systemic morbidity in a longitudinal cohort of Sjögren's syndrome.
    Ophthalmology. 2015 Jan;122(1):56-61. doi: 10.1016/j.ophtha.2014.07.026. Epub
    2014 Aug 30. PubMed PMID: 25178806.

    Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies
    recognising sulfated carbohydrates are prevalent in systemic sclerosis and
    associated with pulmonary vascular disease. Ann Rheum Dis. 2011
    Dec;70(12):2218-24. doi: 10.1136/ard.2011.153130. Epub 2011 Aug 26. PubMed PMID:
    21873333; PubMed Central PMCID: PMC3409247.

    O'Shaughnessy MJ, Chen ZM, Gramaglia I, Taylor PA, Panoskaltsis-Mortari A,
    Vogtenhuber C, Palmer E, Grader-Beck T, Boussiotis VA, Blazar BR. Elevation of
    intracellular cyclic AMP in alloreactive CD4(+) T Cells induces
    alloantigen-specific tolerance that can prevent GVHD lethality in vivo. Biol
    Blood Marrow Transplant. 2007 May;13(5):530-42. PubMed PMID: 17448912.

    Park JK, Subhawong AP, Ziminski CM, Grader-Beck T. Dermatomyositis as the
    initial presentation of a large anaplastic T-cell lymphoma. J Clin Oncol. 2011
    May 1;29(13):e378-80. doi: 10.1200/JCO.2010.33.2528. Epub 2011 Feb 22. PubMed
    PMID: 21343565.

    Grader-Beck T, Casciola-Rosen L, Lang TJ, Puliaev R, Rosen A, Via CS.
    Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose)
    polymerase 1 in a murine model of lupus. J Immunol. 2007 Jan 1;178(1):95-102.
    PubMed PMID: 17182544.

    Grader-Beck T, Wigley FM. Raynaud's phenomenon in mixed connective tissue
    disease. Rheum Dis Clin North Am. 2005 Aug;31(3):465-81, vi. Review. PubMed PMID:
    16084319.

    Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA. cAMP inhibits
    both Ras and Rap1 activation in primary human T lymphocytes, but only Ras
    inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb
    1;101(3):998-1006. Epub 2002 Sep 19. PubMed PMID: 12393539

    Appleman LJ, Tzachanis D, Grader-Beck T, van Puijenbroek AA, Boussiotis VA.
    Helper T cell anergy: from biochemistry to cancer pathophysiology and
    therapeutics. J Mol Med (Berl). 2001;78(12):673-83. Review. PubMed PMID:
    11434720.

    Appleman LJ, Tzachanis D, Grader-Beck T, Van Puijenbroek AA, Boussiotis VA.
    Induction of immunologic tolerance for allogeneic hematopoietic cell
    transplantation. Leuk Lymphoma. 2002 Jun;43(6):1159-67. Review. PubMed PMID:
    12152983

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Memberships

    • American College of Physicians, 2006
    • American College Of Rheumatology, 2003
  • Videos & Media +
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