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Lisa Christopher, M.D., M.P.H.

Photo of Dr. Lisa Christopher, M.D., M.P.H.

Director, Johns Hopkins Myositis Center

Associate Professor of Medicine

Specializes in: Adults (18+ years)

Female

Expertise: Critical Care Medicine; Anesthesiology, Inclusion Body Myositis, Myositis, Rheumatology

Research Interests: Dermatomyositis, Polymyositis, Inclusion Body Myositis, Inflammatory Myopathy, Necrotizing Myopathy, Statin Myopathy

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Locations

Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-1552

Myositis Center
301 Mason Lord Drive
Baltimore, MD 21224 map
Phone: 410-550-6962

Contact for Research Inquiries

Johns Hopkins Myositis Center
5200 Eastern Ave
Mason F. Lord Tower Suite 4500
Baltimore, MD 21224 map

Background

Dr. Christopher-Stine is currently Director of the Johns Hopkins Myositis Center. She is an Associate Professor of Medicine and Neurology. She also serves as one of the Johns Hopkins University School of Medicine College Advisors, and is a Board Member of the Johns Hopkins Institutional Review Board (IRB 5).  Dr. Christopher-Stine graduated Cum Laude with a B.A. in chemistry from Franklin and Marshall College; was elected to Alpha Omega Alpha at Hahnemann University School of Medicine, where she received her MD degree, and she attained her Master of Public Health degree from the Johns Hopkins Bloomberg School of Public Health. Her internship and residency training were completed at MCP Hahnemann University, where she also served as Chief Resident, after which she pursued rheumatology fellowship training at Johns Hopkins.

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Titles

  • Director, Johns Hopkins Myositis Center
  • Associate Professor of Medicine
  • Associate Professor of Neurology

Centers & Institutes

Education

Degrees

  • MD, Hahnemann University School of Medicine (1997)

Residencies

  • Drexel University College of Medicine / Internal Medicine (2001)

Fellowships

  • Johns Hopkins University School of Medicine / Rheumatology (2003)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2000, 2023)
  • American Board of Internal Medicine / Rheumatology (2003, 2017)

Research & Publications

Research Summary

Dr. Christopher-Stine’s primary research focus is clinical research pertaining to inflammatory myopathies – specifically describing unique phenotypes, novel therapeutic approaches, and novel disease subsets among patients with inflammatory myopathies who are part of the growing cohort of over 2000 patients evaluated clinically for confirmed or suspected muscle disease at the Myositis Center who agree to be part of the Johns Hopkins Myositis database. Dr. Christopher-Stine and her colleagues made the novel discovery of an autoimmune myopathy closely linked to statins. She has a continued interest in statins and their toxicities toward muscle, both as a direct muscle toxin as well as its contribution to autoimmune muscle injury.

Dr. Christopher-Stine and her team are currently investigating several area of interest regarding the inflammatory myopathies. They are interested in cardiovascular complications in the inflammatory myopathies as well as the utilization of MRI imaging to help predict clinical phenotype, and they remain interested in predicting clinical outcomes. In addition, they are currently investigating the burden of calcinosis in adult dermatomyositis by patient self-report and then utilizing novel imaging modalities to examine the extent of calcinosis in these patients. In addition, as patient reported outcomes are growing increasingly important, especially in the context of clinical trials, they are an increasing focus of investigative efforts at the Myositis Center. Specifically, Dr. Christopher-Stine and her team are undertaking an international effort to determine the most appropriate patient-driven outcome measures in the inflammatory myopathies.

Technology Expertise Keywords

Anti-HMGCR autoantibodies

Clinical Trial Keywords

Dermatomyositis, Polymyositis, Inclusion Body Myositis, Inflammatory Myopathy, Necrotizing Myopathy, Statin Myopathy

Selected Publications

View all on Pubmed

    1. Christopher-Stine L, Astor B Petri M, Fine D. Protein:Creatinine Ratio is A Reliable Measure of Proteinuria in Lupus Nephritis. J Rheumatol 2004;31:1557-9.
    2. Kalluri M, Sahn SA, Oddis CV, Gharib, Christopher-Stine, L, Danoff SK, Casciola-Rosen L, Hong G3, Dellaripa PF, Highland KB. Clinical profile of anti-PL-12 autoantibody: Cohort Study and Review of the Literature. Chest. 2009 Jun;135(6):1550-6.
    3. Valiyil R, Hong G, Casciola- Rosen L, Mammen AL, Christopher-Stine, L. Rituximab is an Effective Therapy for Myopathy Associated with Anti-Signal Recognition Particle Antibodies: A Case Series. Arthritis Care Res. 2010 Sep;62(9):1328-34
    4. Christopher-Stine L, Hong G, Casciola-Rosen L, Corse A, Mammen AL. A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66
    5. Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase (HMGCR) in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
    6. Petri MA, Kiani AN, Post W, Christopher-Stine L, Magder LS. Lupus Atherosclerosis Prevention Study (LAPS).Ann Rheum Dis. 2011 May;70(5):760-5.
    7. Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Care Res. 2012 Aug;64(8):1233-7.
    8. Casciola-Rosen L, Hall JC, Christopher-Stine L, Mammen AL, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):548-53.
    9. Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, Lloyd TE Mammen AL. Antibody Levels Correlate with Creatine Kinase Levels and Strength in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis Rheum. 2012 Dec;64(12):4087-93.
    10. Alexanderson H, Del Grande M, Bingham III CO, Orbai AM, Sarver C, Clegg-Smith K, Lundberg IE, Song YW, Christopher-Stine L. Patient Reported outcomes and Adult Patients' disease experience in the Idiopathic Inflammatory Myopathies. A report from the OMERACT 11 Myositis Special Interest Group. J Rheumatol. 2014 Apr;41(4):792-8.
    11. ENMC Myositis Muscle Biopsy Study Group. 193rd ENMC International workshop pathology diagnosis of idiopathic inflammatory myopathies 30 November – 2 December 2012, Naarden, The Netherlands. Neuromuscular Disorders 2013 (23): 945–951.
    12. Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L.Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1-gamma. Arthritis Rheum. 2013 Nov;65(11):2954-62.
    13. Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. Brief Report: Antisynthetase Syndrome-Associated Myocarditis. J Card Fail. 2014 Jul 29
    14. Johnson C, Connors GR, Oaks J, Han S, Truong A, Richardson B, Lechtzin N, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Danoff SK. Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type. Respir Med. 2014 Sep 18
    15. Christopher-Stine L. Siedner M, Lin J, Haas M, Parekh H, Petri M, Fine DM. Renal Biopsy in Lupus Patients with Low Levels of Proteinuria. J Rheumatol. 2007 Feb;34(2):332-5.
    16. Hall JC, Casciola-Rosen L, Samedy LA, Werner J, Oyoyemi K, Danoff SK, Christopher-Stine L. Anti melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. Arthritis Care Res. 2013 Aug;65(8):1307-15.
    17. Lloyd TE* , Christopher-Stine L*, Penal-Fernandez I, Tiniakou E, Petri M, Baer A, , Danoff SK, Pak K, Casciola-Rosen L , and Mammen AL . Cytosolic 5'-nucleotidase 1A is a common target of circulating autoantibodies in several autoimmune diseases; Arthritis Rheum , 2015 Apr 17(Epub)

Academic Affiliations & Courses

Courses and Syllabi

  • Physical Diagnosis Course
    Hahnemann University
    1999 - 2001
  • Johns Hopkins University
    Clinical Skills Course
    Johns Hopkins University
    2001 - 2010
  • Advanced Ambulatory Clerkship in Musculoskeletal Medicine
    Johns Hopkins University
    2004 - 2004
  • Pathophysiology; Rheumatic Disease Course
    Johns Hopkins University
    2005 - 2009
  • Immunology II
    Johns Hopkins University
    2010 - 2010
  • Colleges Advisory Program Core Faculty
    Taussig College
    2012

Activities & Honors

Honors

  • Whos Who in America, Marquis , 2009
  • Castle Connolly Medical Ltd. Americas Top Doctors, 2008
  • Who's Who of American Women, Marquis , 2008
  • Who's Who in Science and Engineering, Marquis , 2007
  • The Golden Stethoscope Award Winner, 2001
  • The Golden Stethoscope Award Nominee, 2000
  • C. Nelson Davis Award , 1998
  • Wyeth-Ayerst Award for Excellence in Infectious Diseases, 1998
  • Elizabeth Blackwell Memorial Award to the Outstanding Senior Woman, 1997
  • Hahnemann Physicians Society Award, Hahnemann Physicians Society, 1997
  • Van Buren O. Hammet Memorial Award Prize, 1997
  • William Likoff, M.D. Award, 1997
  • Alpha Omega Alpha Honor Society, 1996
  • Memorial Scholarship , Alpha Phi Sorority Howell , 1996
  • Scholarship, William Goldman Foundation , 1995
  • Betty Ford Center Professional-in-Residence participant, 1995
  • Phi Beta Kappa Honor Society, 1992
  • Outstanding Performance in Psychiatry, Van Buren O. Hammet Memorial Award, 1997
  • Ken Titus Award for the Best Lecture, Virginia Society of Rheumatologists, 2009
  • Leadership Program for Women Faculty, Johns Hopkins University, 2010
  • Scholarship Award Recipient, Sexton, 2014

Memberships

  • Alpha Omega Alpha
  • American Medical Women’s Association, 1992 - 1997
  • American Medical Women’s Association, 1993 - 1994

    Chapter President

  • Philadelphia County Medical Society, Pennsylvania Medical Society, 1997 - 2000
  • Philadelphia County Medical Society, Pennsylvania Medical Society, 2000 - 2001

    Vice Chair

  • Maryland Society for The Rheumatic Diseases, 2001

    Member

  • American College of Rheumatology, 2003

    Fellow Member

  • Maryland Society for the Rheumatic Diseases, 2006

    President

  • The Myositis Association Medical Advisory Board, 2009 - 2014

    Member

  • The Myositis Association, 2012 - 2012

    Chair, The Nominating Committee

Professional Activities

  • Abstract Selection Committee on Myositis and Myopathies, ACR, 2006
  • Barker Firm Faculty , Johns Hopkins University, 2005
  • Graduate Medical Education Committee, MCP Hahnemann University, 1998 - 2001
  • Intern Selection Sub-committee, Johns Hopkins University, 2005
  • Medical Advisory Board, The Myositis Association, 2009
  • Pharmacy and Therapeutics Committee, MCP Hospital, 2000 - 2001
  • WorkLife Advisory Group, Johns Hopkins, 2007
  • Member, Departments of Medicine’s Task Force on Women’s Academic Careers in Medicine
  • Advisor, College Advisory Program
  • Board Member, Institutional Review Board (IRB 5)
  • Philanthropy Chair, Departments of Medicine’s Task Force on Women’s Academic Careers in Medicine

Videos & Media

Lectures and Presentations

  • “A 55 Year-old Man with Underlying Diabetic Nephropathy Presents with a Rapidly Rising Creatinine,”
    Speaker , Philadelphia, PA (05/01/1997)
    Hahnemann University Hospital Morbidity and Mortality Conference
  • Does Bankruptcy Influence Medical Education?
    Speaker , Philadelphia, PA (05/01/2001)
    MCP Hospital Medicine Grand Rounds
  • Clinicopathologic Conference
    Speaker , Philadelphia, PA (06/01/2001)
    Hahnemann University Hospital Grand Rounds
  • Cardiovascular Complications of SLE
    Speaker , Baltimore, MD (11/09/2002)
    Maryland Lupus Foundation
  • Lupus and Cardiovascular Disease
    Speaker , Baltimore, MD (10/04/2003)
    Lupus Foundation of Greater Washington
  • Management of Women with Fibromyalgia and Chronic Fatigue Syndrome
    Speaker , Baltimore, MD (12/04/2003)
    Women's Health Symposium
  • Polymyositis and Dermatomyositis: Recognition and Treatment
    Speaker , Baltimore, MD (01/16/2005)
    Rheumatology Symposium
  • Dermatomyositis
    Speaker , Baltimore, MD (10/13/2005)
    Johns Hopkins University Grand Rounds
  • Atorvastatin Does Not Increase Bone Mineral density in SLE
    Plenary Speaker , Barcelona, Spain (06/15/2007)
    EULAR (European League Against Rheumatism)
  • Atorvastatin Treatment Does Not Reduce Cytokines or Cell Adhesion Molecules in SLE
    Speaker , Boston, MA (11/10/2007)
    American College of Rheumatology Concurrent Session
  • The Antisynthetase Syndrome
    Speaker , Philadelphia, PA (11/14/2007)
    Drexel University College
  • The Antisynthetase Syndrome
    Speaker , Washington DC (10/13/2008)
    Children's National Medical Center
  • What We Know About Statins and Myositis
    Speaker , Denver, CO (09/20/2008)
    The Myositis Association Annual Conference
  • Coping with Prednisone
    Speaker , Denver, CO (09/20/2008)
    The Myositis Association Annual Conference
  • Managing your disease (polymyositis)
    Speaker , Denver, CO (09/20/2008)
    The Myositis Association Annual Conference
  • Myositis: 32 Flavors and Then Some
    Speaker , Hot Springs, VA (09/29/2008)
    Virginia Society of Rheumatolgists
  • Myositis 101: A Clinical Review of the Diagnosis and Treatment of Inflammatory Myopathies and their Mimics
    Speaker , Monmouth, NJ (10/09/2008)
    Monmouth Medical Center - Department of Internal Medicine Medical Grand Rounds
  • The Antisynthetase Syndrome
    Speaker , Boston, MA (01/27/2009)
    Massachusetts General Hospital Rheumatology Grand Rounds
  • A Novel Autoantibody Against 200/100 kDa Is Associated with a Necrotizing Myopathy
    Plenary Speaker , Philadelphia, PA (10/19/2009)
    ACR Discovery 2009 Plenary Session
  • Myositis 101
    Speaker , Kansas City, MO (11/05/2009)
    Kansas City Southwest Clinical Society
  • Myositis: A Review
    Speaker , Baltimore, MD (11/11/2009)
    Johns Hopkins University Neurology
  • Myositis 101: A Physician’s Primer
    Speaker , Baltimore, MD (11/20/2009)
    MedStart Harbor Hospital Grand Rounds
  • Myositis Update: Many Shapes and Sizes
    Speaker , Carey, NC (10/17/2010)
    North Carolina Rheumatology Association
  • Myositis Update
    Speaker , Baltimore, MD (06/04/2010)
    Advances in the Diagnosis and Treatment of the Rheumatic Diseases
  • Anti-HMGCoA Reductase- Associated Myopathy: Bedside to Bench and Back
    Speaker , Baltimore, MD (02/02/2011)
    Neurology Resident Noon Conference
  • Anti-HMGCoA Reductase- Associated Necrotizing Myopathy: Bedside to Bench and Back
    Speaker , Los Angeles, CA (04/27/2011)
    Cedars-Cinai Medical Center Rheumatology Grand Rounds
  • Anti-HMG CoA- Reductase Associated Myopathy: An Illustration of Collaboration
    Speaker , Bethesda, MD (05/11/2011)
    National Institute of Health
  • What’s new in Myositis: Autoimmune Necrotizing Myopathy – the New Kid on the Block?
    Speaker , New York, NY (05/19/2011)
    New York State Rheumatology Association
  • 21-year-old man with fever, rash, arthritis, and pulmonary lesions
    Discussant , Boston, MA (06/23/2011)
    Massachusetts General Hospital Grand Rounds
  • Anti-HMGCoA Reductase- Associated Necrotizing Myopathy : Shaping our Understating of The Inflammatory Myopathies
    Speaker , New York, NY (10/07/2011)
    Columbia University College of Physicians and Surgeons Rheumatology Rounds
  • Statin Myopathies
    Speakers , Chicago, IL (11/08/2011)
    American College of Rheumatology Annual Scientific Meeting
  • Calcinosis
    Speaker , Chicago, IL (04/29/2012)
    ACR Stater of the Art Clinical Symposium
  • Dermatomyositis Treatment
    Speeaker , Chicago, IL (04/29/2012)
    ACR Stater of the Art Clinical Symposium
  • Statin Myopathy in Evolution: Immune Mediated Necrotizing Myopathy and the Anti-HMGCR Connection
    Keynote Speaker , Philadelphia, PA (05/01/2012)
    Philadelphia Rheumatism Society Annual Scientific Lecture
  • Bench to Bedside and Back Again: Autoimmune Statin Myopathy and the Anti-HMGCR Story
    Speaker , Stockholm, Sweden (09/25/2012)
    Karolinska Institutet
  • Statin Myopathy
    Speaker , Stockholm, Sweden (09/27/2012)
    2012 Cutting Edge Rheumatology
  • Statin-associated autoimmune myopathy: from bedside to bench and back again
    Speaker , Bethesda, MD (10/17/2012)
    Walter Reed National Military Medical Center at Bethesda
  • Statin Myopathy in Evolution: When is It Autoimmune?
    Speaker , Detroit, MI (10/18/2012)
    Henry Ford Health System Grand Rounds
  • Statin Myopathy
    Speaker/Discussant , Naarden, Netherlands (12/01/2012)
    European Neuromuscular Centre (ENMC) 193rd meeting
  • The Ever-Changing World of Statin Myopathies
    Speaker , Washington DC (03/07/2013)
    Georgetown University
  • The ABCs of Myositis - How antibodies can determine clinical features
    Speaker , Orlando, FL (07/20/2013)
    Florida Society of Rheumatology Annual Meeting
  • Healthy Living Despite Myositis
    Speaker , Louisville, KY (10/19/2013)
    The Myositis Association Annual Patient Conference
  • Myositis Mimics
    Speaker , Boston, MA (11/08/2013)
    Harvard, MA
  • Autoimmune Statin-Associated Myopathy- The Plot Thickens
    Speaker , Brooklyn, NY (11/07/2013)
    SUNY Downstate Medical Center Medical Grand Rounds
  • Myositis Update
    Speaker , Baltimore, MD (04/12/2014)
    Johns Hopkins 10th Annual Advances in the Diagnosis and Treatment of the Rheumatic Diseases
  • Stain Myopathy in Evolution:Exploring the Link to Autoimmunity
    Speaker , New York, NY (04/15/2014)
    Mount Sinai Beth Israel Medical Grand Rounds
  • Patient Reported Outcomes in the Idiopathic Inflammatory Myopathies
    Speaker/Discussant , Budapest, Hungary (05/09/2014)
    OMERACT Special Interest Group
  • The ABCs of Myositis
    Speaker , Rochester, NY (05/29/2014)
    University of Rochester Medical Grand Rounds
  • Statin Myopathy: An Autoimmune disease?
    Speaker , Baltimore, MD (06/06/2014)
    Center for Autoimmune Disease Research - The Bloomberg School of Public Health, Johns Hopkins University
  • Management of Interstitial Lung Disease in Myositis
    Speaker , Annual Meeting Update on Management and Classification of Myositis Clinical Science Session , Paris, France (06/14/2014)
    European League Against Rheumatism
  • Myositis 101: Polymyositis, Dermatomyositis, and Related Inflammatory Myopathies
    Speaker , Annual Conference , Louisville, KY (08/08/2014)
    Rheuamtology Nurses Society
  • Statin Myopathy: An Autoimmune Disease?
    Speaker , Medical Grand Rounds , New Orleans, LA (08/29/2014)
    LSU Health Science Center
  • Promising Research in PM and DM
    Speaker , Annual Patient Conference , Reno, NV (09/06/2014)
    The Myositis Association
  • Statin Myopathy: When is it Autoimmune?
    Speaker , Rheumatology Grand Rounds , Chicago, IL (09/16/2014)
    University of Chicago
  • The Elevated CPK – Including Statins
    Speaker , 10th Kenneth Austin RheumatologySymposium , Washington DC (04/01/2015)
    Howard University
  • Statin Myopathy Associated with Anti-HMGCR Autoantibodies
    Speaker , Strategic Advisory Meeting , Boston, MA (04/14/2015)
    Inova Diagnostics
  • Statin Myopathy: When is it Autoimmune?
    Speaker , Medical Grand Rounds , Detroit, MI. (04/22/2015)
    Beaumont Hospital
  • Difficult Myositis: challenging Idiopathic Inflammatory Myopathy Cases
    Speaker , Annual Meeting , Charleston, SC (04/26/2015)
    South Carolina Rheumatism Society
  • Myositis Update: Then and Now
    Speaker , Medical Grand Rounds , Baltimore, MD (05/06/2015)
    St. Joseph’s Medical Center Medica
  • Myositis Patient Reported Outcomes
    Moderator , Stockholm, Sweden (05/09/2015)
    The Lung in Myositits
  • Myositis Patient Reported Outcomes
    Speaker , The First International Conference on Myositis , Stockholm, Sweden (05/11/2015)
  • Creating a Center of Excellence
    Speaker , Your Academic Clinical Practice Toolkit Maximizing Your Success Seminar , Baltimore, MD (08/03/2015)
    Johns Hopkins Hospital
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