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Wei Dong Gao, MD

Associate Professor of Anesthesiology and Critical Care Medicine
Appointment Phone


Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Associate Professor of Anesthesiology and Critical Care Medicine



Research Interests

Oxidative Stress in Heart Failure; Excitation-contraction Coupling in Ischemia/reperfusion and Heart Failure; Cardiac Muscle Physiology


  • English
  • Chinese


American Society of Anesthesiology

Additional Resources

Additional Resources +
  • Education +


    • Faculty of Medicine University of Calgary (Calgary Alberta ) (1992)
    • Harbin Medical University (Harbin City ) (1982)


    • University of Cincinnati Hospital - GME (Cincinnati OH) (2001)


    • Johns Hopkins University School of Medicine / Cardiac Anesthesiology (Baltimore MD) (2002)
    • Faculty of Medicine University of Calgary (Calgary Alberta ) (1992)


    • American Board of Anesthesiology / Anesthesiology (2004)
  • Research & Publications +

    Selected Publications

    A. Selected Peer-reviewed articles

    1. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. Mechanism of force inhibition by 2,3-butanedione monoxiime in rat cardiac muscle: role of intracellular calcium and cross-bridge Kinetics. J Physiol. 476:487-500, 1994).

    2. Gao, W.D., Backx, P.H., Azan-Backx, M.D., Marban, E. Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res. 74;408-415, 1994.

    3. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. The relationship between contractile force and intracellular [Ca2+]i in intact rat cardiac trabeculae. J Gen Physiol. 105:1-19, 1995.

    4. Gao, W.D., Atar, A., Backx, P.H., Marban, E. Relationship between intracellular calcium and contractile force in stunned myocardium: Direct evidence for decreases myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res. 76:1036-1048, 1995

    5. Gao, W.D., Liu, Y., Mellgren, R., Marban, E. Intrinsic myofilaments alterations underlying the decreased contractility of stunned myocardium: A consequence of calcium-dependent proteolysis? Circ Res. 78:455-465, 1996.

    7. Liu, Y., Gao, W.D., O''Rourke, B., Marban, E. Synergistic potentiation of ATP-sensitive potassium currents by protein kinase C and adenosine: Implications for ischemic preconditioning. Circ Res. 78:443-454, 1996.

    8. Gao, W.D., Liu, Y., Marban, E. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implications for the mechanism of stunned myocardium. Circulation 94:2597-2604, 1996.

    9. Gao, W.D., Atar, D., Liu, Y., Perez, N.G., Murphy, A.M., Marban, E. Role of troponin I proteolysis in the pathogenesis of myocardial stunning. Circ Res. 80:393-399, 1997.

    10. Gao, W.D., Perez, N.G., Marban,E. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol. 507:175-184, 1998.

    11. Perez, N.G., Gao, W.D., Marban, E. Novel myofilament calcium-sensitizing property of xanthine oxidase inhibitors. Circ Res. 83:423-430, 1998.

    12. Gao, W.D., Perez, N.P., Seidman, C., Seidman, J., Marban, E. Altered cardiac excitation-contraction coupling in cardiac muscle from mutant mice with familial hypertrophic cardiomyopathy. J Clin Invest. 103:661-666, 1999.

    13. Stull, L.B., Leppo, M.K., Szweda, L., Gao, W.D., Marban, E. Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy. Circ Res. 95:1005-1011, 2004.

    14.Gao, W.D., Dai, T., Nyhan, D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol. 290:H886-H893, 2006.

    15. Dai, T., Ramirez-Correa, G., Gao, W.D. Apelin increases contractility in failing cardiac muscle. Eur J Pharma. 553:222-228, 2006)

    16. Bilchick, K., Duncan, J.G., Ravi, R., Takimoto, E., Champion, H.C., Gao, W.D., Stull, L.S., Kass, D.A., Murphy, A.M. Heart failure-associated alterations in troponin I phosphorylation impair left ventricular relaxation response to afterload, force-frequency response and systolic function. Am J Physiol. 292:H318-325, 2007.

    17. Tocchetti, C.G., Wang, W., Froehlich, J.P., Valdivia, H.H., Pavlos, C.M., Aon, M., Wilson, G.M., di Benedetto, G., O Rourke, B., Miranda, K.M., Mancardi, D., Wink, D.A., Zaccolo, M., Toscano, J.P., Cheng, H., Gao, W.D., Kass, D.A., Paolocci, N. Nitroxyl (HNO) enhances sarcoplasmic reticulum Ca2+ cycling to increase cardiac contractility and relaxation Circ Res 100:96-104, 2007.

    18. Dai, T., Tian, Y., Tocchetti, C.G., Katori, T.A., Kass, D.A., Paolocci, N., Gao, W.D. Nitroxyl anion (HNO/NO-) increases myofilament Ca2+ responsiveness in rat cardiac muscle. J Physiol. 580:951-960, 2007. (accompanying perspective by RJ Solaro: 580:697)

    19. Jin, W., Z. Zhao, G.A. Ramirez-Correa, X. Zhong, W.D.Gao, G.W. Hart, A.M. Murphy. O-linked GlcNac Modification of Cardiac Myocardial Contractile Function. Circ Res. 103(12):1354-8, 2008

    B. Selected book chapters and reviews

    1. Marban, E., Gao, W.D. Stunned myocardium: a disease of the myofilaments? Basic Res Cardiol. 90:269-272, 1995.

    2. Liu, Y., Gao, W.D., ORourke, B., Marban, E. Protein kinase C and adenosine synergistically activate ATP-sensitive potassium currents: Implications for ischemic preconditioning. In Adenosine, cardioprotection and clinical application. Eds: R.M. Mentzer, Jr, M. Kitakaze, J.M. Downey, M. Hori. Kluwer Academic Publishers, Boston, pp153-166,1997.

    3. Gao, W.D., Marban, E. Myocardial stunning and preconditioning: clinical implications. In Perioperative Care of Cardiopulmonary Comprised Patients. Eds L Flesher and DS Prough, 13(2):pp172-180, 2001.

    4. Gao, W.D., Murphy, A. Local Control in Thin Filament Activation of Cardiac Muscle. (Perspective) J Physiol. 580:358, 2007.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    5/1987 - 5/1989: William H. Davis Scholarship for Medical Research, Graduate Studies, University of Calgary, Canada

    9/1992 - 8/1994: International Research Fellowship, American Heart Association. USA

    7/2002 - 6/2004: Clinician-Scientis Award, JHU School of Medicine.
  • Videos & Media +
  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-7519
    Appointment Phone: 410-955-7519
    Fax: 410-955-0994
    Location Map


    • Anesthesiology and Critical Care Medicine - Cardiac Anesthesia

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