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Susan Henrietta Eshleman, M.D., Ph.D.

Photo of Dr. Susan Henrietta Eshleman, M.D., Ph.D.

Director, HIV Prevention Trials Network (HPTN) Laboratory Center

Professor of Pathology

Female

Expertise: Pathology

Research Interests: HIV diversity; HIV transmission, disease progression, and treatment outcomes; evaluation of interventions for HIV prevention

Locations

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-2660

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-955-2660

4940 Eastern Avenue
Baltimore, MD 21224 map

Background

Dr. Susan Eshleman is a Professor of Pathology at the Johns Hopkins University School of Medicine. She earned her M.D. and Ph.D. from the University of Pennsylvania School of Medicine, and then completed a residency in Clinical Pathology and fellowship in Transfusion Medicine at the Hospital of the University of Pennsylvania.

Dr. Eshleman's research program includes basic, translational, and clinical research. She provides clinical support to the Dept. of Pathology in Blood Banking and Transfusion Medicine. She also is a member of the Cellular and Molecular Medicine (CMM) and Pathobiology PhD training programs at JHU. She trains graduate students and post-doctoral fellows, and received the Dept. of Pathology's teaching award in 2000.

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Titles

  • Director, HIV Prevention Trials Network (HPTN) Laboratory Center
  • Professor of Pathology

Departments / Divisions

Education

Degrees

  • MD, Hospital of the University of Pennsylvania (1987)

Residencies

  • Hospital of the University of Pennsylvania / Clinical Pathology (1992)

Fellowships

  • Hospital of the University of Pennsylvania / Transfusion Medicine (1993)

Board Certifications

  • American Board of Pathology / Blood Banking/Transfusion Medicine (1999)
  • American Board of Pathology / Clinical Pathology (1991)

Research & Publications

Research Summary

Dr. Eshleman's research program includes basic, translational, and clinical research. Her basic research program is focused on HIV diversity and its impact on HIV transmission, disease progression, and treatment outcomes. Her translational research program is focused on development and evaluation of assays and laboratory methods for HIV analysis. Dr. Eshleman directs two CAP-accredited laboratories at JHU: the HIV Genotyping Laboratory and the HIV Clinical Research Laboratory. Her clinical research program is focused on HIV prevention. She is also the Director of the HPTN Laboratory Center, one of three leadership groups of the NIH-sponsored HIV Prevention Trials Network (HPTN). This network performs cohort studies and clinical trials evaluating behavioral, biomedical, and structural interventions for HIV prevention in the US, Africa, South America, Asia, and Eastern Europe. Dr. Eshleman was part of the HPTN 052 study team. This landmark clinical trial showed that early HIV treatment with antiretroviral drugs prevented >90% of sexual HIV transmissions; the finding was named "Breakthrough of the Year" in 2011 by the journal Science.

Lab

Dr. Eshleman's research program includes basic, translational, and clinical research.

Selected Publications

Eshleman SH, Mracna M, Guay LA, Deseyve M, Cunningham S, Mirochnick M, Musoke P, Fleming T, Fowler MG, Mofenson LM, Mmiro F, and Jackson JB. Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET-012). AIDS, 2001; 15:1951-1957.

Cohen M, Ying C, McCauley M, Gamble T, Hosseinipour M, Kumarasamy N, Hakim J, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole S, Mehendale S, Chariyalertsak S, Santos B, Mayer K, Hoffman I, Eshleman S, Piwowar-Manning E, Wang L, Mekhema J, Mills L, De Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Taha T, Nielsen K, Celentano D, Essex M, and Flemming T. Prevention of HIV-1 infection with antiretroviral therapy: Results from HPTN 052. New Engl J Med. 2011; 365:493-505.

Laeyendecker O, Brookmeyer R, Cousins MM, Mullis C, Konikoff J, Donnell D, Celum C, Buchbinder SP, Seage GR, Kirk GD, Mehta SH, Astemborski J, Jacobson LP, Margolick JB, Brown J, Quinn TC, and Eshleman SH. HIV incidence determination in the United States: A multi-assay approach. J Infect Dis. 2013; 207:232-239.

Coates TJ, Kulich M, Zelaya CE, Celantano DD, Chariyalertsak S, Chingono A, Gray G, Mbwambo JKK, Morin FS, Richter L, Sweat M, van Rooven H, McGrath N, Fiamma A, Laeyendecker O, Piwowar-Manning E, Szerekes G, Donnell D, and Eshleman SH. Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. Lancet Global Health.2014. 2:e267-e277.

Fogel JM, Piwowar-Manning E, Donohue K, Cummings V, Marzinke MA, Clarke W, Breaud A, Fiamma A, Donnell D, Kulich M, Mwambo JKK, Richter L, Gray G, Sweat M, Coates TJ, and Eshleman SH. Determination of HIV status in African adults with discordant HIV rapid tests. J AIDS. 2015; 69:430-438.

Activities & Honors

Honors

  • Poster Award for Outstanding Content and Presentation, 5th International Workshop on HIV Drug Resistance and Treatment Strategies, 2001
  • Faculty Teaching Award, Department of Pathology, The Johns Hopkins University, 2000
  • MetPath Fellowship in Laboratory Medicine, MetPath Inc., 1992 - 1993
  • ACLPS Young Investigator Award for Excellence in Research, 1992
  • Upjohn Achievement Award for Excellence in Biomedical Research, 1987
  • Association of M.I.T. Alumnae Senior Academic Award, 1980

Professional Activities

  • Pathobiology PhD Training Program
  • Pathobiology PhD Training Program
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