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Photo of Dr. Pedram Argani, MD

Pedram Argani, MD

Director and principal consultant, Breast Pathology Service
Professor of Pathology
Male
Appointment Phone

410-955-2660

Main Location

The Johns Hopkins Hospital

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Titles

  • Director and principal consultant, Breast Pathology Service
  • Director, Immunohistochemistry Laboratory, Johns Hopkins Hospital
  • Professor of Pathology
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Pathology

Research Interests

Breast cancer; Breast cancer genetics

Biography

Dr. Pedram Argani is a professor of pathology at the Johns Hopkins University School of Medicine. His area of clinical expertise is breast pathology, where he reviews approximately 1,000 breast consultation cases each year. He is internationally recognized as an expert anatomic pathologist.

Dr. Argani serves as the director and principal consultant of the Breast Pathology Service in the Sidney Kimmel Comprehensive Cancer Center and as the director of the Immunohistochemistry Laboratory at The Johns Hopkins Hospital.

He received his undergraduate degree from Princeton University. He earned his M.D. from University of Pennsylvania Health System School of Medicine where he also completed his residency in anatomic pathology. Dr. Argani performed a fellowship in oncologic and molecular pathology at Memorial Sloan-Kettering Cancer Center.

Dr. Argani is a member of the steering committee of the Breast Center at Johns Hopkins. He is on the editorial board of numerous scientific journals, including the American Journal of Surgical Pathology, the American Journal of Clinical Pathology, Modern Pathology, and the International Journal of Surgical Pathology. Dr. Argani won the Arthur Purdy Stout Prize from the United States and Canadian Academy of Pathology for his contributions to the advancement of diagnostic pathology.

Languages

  • English
Additional Resources +
  • Education +

    Training

    • University of Pennsylvania Health System School of Medicine (Philadelphia PA) (1992)

    Residencies

    • Hospital of the University of Pennsylvania / Anatomic Pathology (Philadelphia PA) (1995)

    Fellowships

    • Memorial Sloan - Kettering Cancer Center (New York NY) (1997)
    • Memorial Sloan - Kettering Cancer Center / Oncologic Pathology (New York NY) (1996)

    Certifications

    • American Board of Pathology / Anatomic Pathology (1997)
  • Research & Publications +

    Selected Publications

    1. Fenton, H.; Carlile, B.; Montgomery, E.A.; Carraway, H.; Herman, J.; Sahin, F.; Su, G.H.; Argani, P. LKB1 protein expression in human breast cancer. Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):146-153.
    2. Gallicchio, L.; Berndt, S.I.; McSorley, M.A.; Newschaffer, C.J.; Thuita, L.W.; Argani, P.; Hoffman, S.C.; Helzlsouer, K.J. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. BMC Cancer. 2006;6:173.
    3. Gallicchio, L.; McSorley, M.A.; Newschaffer, C.J.; Thuita, L.W.; Argani, P.; Hoffman, S.C.; Helzlsouer, K.J. Flame-broiled food, NAT2 acetylator phenotype, and breast cancer risk among women with benign breast disease. Breast Cancer Res Treat. 2006 Sep;99(2):229-233.
    4. Hansel, D.E.; Meeker, A.K.; Hicks, J.; De Marzo, A.M.; Lillemoe, K.D.; Schulick, R.; Hruban, R.H.; Maitra, A.; Argani, P. Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma. Mod Pathol. 2006 Jun;19(6):772-779.
    5. Judson, K.; Argani, P. Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. Am J Surg Pathol. 2006 Jul;30(7):912-918.
    6. Karakas, B.; Weeraratna, A.; Abukhdeir, A.; Blair, B.G.; Konishi, H.; Arena, S.; Becker, K.; Wood, W., 3rd; Argani, P.; De Marzo, A.M.; Bachman, K.E.; Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene. 2006 Sep 7;25(40):5561-5569.
    7. Lo, P.K.; Mehrotra, J.; D''Costa, A.; Fackler, M.J.; Garrett-Mayer, E.; Argani, P.; Sukumar, S. Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther. 2006 Mar;5(3):281-286.
    8. Swift-Scanlan, T.; Blackford, A.; Argani, P.; Sukumar, S.; Fackler, M.J. Two-color quantitative multiplex methylation-specific PCR. Biotechniques. 2006 Feb;40(2):210-219.
    9. Wu, X.; Chen, H.; Parker, B.; Rubin, E.; Zhu, T.; Lee, J.S.; Argani, P.; Sukumar, S. HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. Cancer Res. 2006 Oct 1;66(19):9527-9534.
    10. Agoston, A.T.; Argani, P.; De Marzo, A.M.; Hicks, J.L.; Nelson, W.G. Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. Am J Pathol. 2007 May;170(5):1585-1593.
    11. Argani, P.; Olgac, S.; Tickoo, S.K.; Goldfischer, M.; Moch, H.; Chan, D.Y.; Eble, J.N.; Bonsib, S.M.; Jimeno, M.; Lloreta, J.; Billis, A.; Hicks, J.; De Marzo, A.M.; Reuter, V.E.; Ladanyi, M. Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum. Am J Surg Pathol. 2007 Aug;31(8):1149-1160.
    12. Cornblatt, B.S.; Ye, L.; Dinkova-Kostova, A.T.; Erb, M.; Fahey, J.W.; Singh, N.K.; Chen, M.S.; Stierer, T.; Garrett-Mayer, E.; Argani, P.; Davidson, N.E.; Talalay, P.; Kensler, T.W.; Visvanathan, K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis. 2007 Jul;28(7):1485-1490.
    13. Lee, J.S.; Lo, P.K.; Fackler, M.J.; Argani, P.; Zhang, Z.; Garrett-Mayer, E.; Sukumar, S. A Comparative Study of Korean with Caucasian Breast Cancer Reveals Frequency of Methylation in Multiple Genes Correlates with Breast Cancer in Young, ER, PR-negative Breast Cancer in Korean Women. Cancer Biol Ther. 2007 Apr 23;6:1114*1120.
    14. Shipitsin, M.; Campbell, L.L.; Argani, P.; Weremowicz, S.; Bloushtain-Qimron, N.; Yao, J.; Nikolskaya, T.; Serebryiskaya, T.; Beroukhim, R.; Hu, M.; Halushka, M.K.; Sukumar, S.; Parker, L.M.; Anderson, K.S.; Harris, L.N.; Garber, J.E.; Richardson, A.L.; Schnitt, S.J.; Nikolsky, Y.; Gelman, R.S.; Polyak, K. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar;11(3):259-273.
    15. Tsuda, M.; Davis, I.J.; Argani, P.; Shukla, N.; McGill, G.G.; Nagai, M.; Saito, T.; Lae, M.; Fisher, D.E.; Ladanyi, M. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007 Feb 1;67(3):919-929.
    16. Abukhdeir, A.M.; Vitolo, M.I.; Argani, P.; De Marzo, A.M.; Karakas, B.; Konishi, H.; Gustin, J.P.; Lauring, J.; Garay, J.P.; Pendleton, C.; Konishi, Y.; Blair, B.G.; Brenner, K.; Garrett-Mayer, E.; Carraway, H.; Bachman, K.E.; Park, B.H. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):288-293.
    17. Argani, P. Understanding Breast Pathology. The Johns Hopkins Breast Cancer Handbook of Healthcare Professionals. Sudbury: Jones and Bartlett Publishers; 2008. p. 37-58.
    18. Cao, D.; Polyak, K.; Halushka, M.K.; Nassar, H.; Kouprina, N.; Iacobuzio-Donahue, C.; Wu, X.; Sukumar, S.; Hicks, J.; De Marzo, A.; Argani, P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10(5):R91.
    19. Cao, D.; Tsangaris, T.N.; Kouprina, N.; Wu, L.S.; Balch, C.M.; Vang, R.; Argani, P. The superficial margin of the skin-sparing mastectomy for breast carcinoma: factors predicting involvement and efficacy of additional margin sampling. Ann Surg Oncol. 2008 May;15(5):1330-1340.
    20. Kleer, C.G.; Bloushtain-Qimron, N.; Chen, Y.H.; Carrasco, D.; Hu, M.; Yao, J.; Kraeft, S.K.; Collins, L.C.; Sabel, M.S.; Argani, P.; Gelman, R.; Schnitt, S.J.; Krop, I.E.; Polyak, K. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008 Sep 1;14(17):5357-5367.
    21. Lee, J.S.; Fackler, M.J.; Teo, W.W.; Lee, J.H.; Choi, C.; Park, M.H.; Yoon, J.H.; Zhang, Z.; Argani, P.; Sukumar, S. Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis. Cancer Biol Ther. 2008 Sep;7(9):1398-1406.
    22. Molavi, D.; Argani, P. Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma. Adv Anat Pathol. 2008 Jan;15(1):1-17.
    23. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most Basal-like Breast Carcinomas Demonstrate the Same Rb-/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically. Am J Surg Pathol. 2008 Oct 17.
    24. Voltura, A.M.; Tsangaris, T.N.; Rosson, G.D.; Jacobs, L.K.; Flores, J.I.; Singh, N.K.; Argani, P.; Balch, C.M. Nipple-sparing mastectomy: critical assessment of 51 procedures and implications for selection criteria. Ann Surg Oncol. 2008 Dec;15(12):3396-3401.
    25. Wu, J.M.; Fackler, M.J.; Halushka, M.K.; Molavi, D.W.; Taylor, M.E.; Teo, W.W.; Griffin, C.; Fetting, J.; Davidson, N.E.; De Marzo, A.M.; Hicks, J.L.; Chitale, D.; Ladanyi, M.; Sukumar, S.; Argani, P. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 2008 Apr 1;14(7):1938-1946.
    26. Albadine, R.; Wang, W.; Brownlee, N.A.; Toubaji, A.; Billis, A.; Argani, P.; Epstein, J.I.; Garvin, A.J.; Cousi, R.; Schaeffer, E.M.; Pavlovich, C.; Netto, G.J. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. J Urol. 2009 Aug;182(2):735-740.
    27. Argani, P.; Aulmann, S.; Karanjawala, Z.; Fraser, R.B.; Ladanyi, M.; Rodriguez, M.M. Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma. Am J Surg Pathol. 2009 Apr;33(4):609-619.
    28. Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.
    29. Carraway, H.E.; Wang, S.; Blackford, A.; Guo, M.; Powers, P.; Jeter, S.; Davidson, N.E.; Argani, P.; Terrell, K.; Herman, J.G.; Lange, J.R. Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence. Breast Cancer Res Treat. 2009 Apr 11;114:315-325.
    30. Chanjuan, S.; Argani, P. Synchronous primary perianal Paget''s disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. Int J Surg Pathol. 2009 Feb;17(1):42-45.
    31. Cimino, A.; Halushka, M.; Illei, P.; Wu, X.; Sukumar, S.; Argani, P. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2009 Dec 11.
    32. Fackler, M.J.; Rivers, A.; Teo, W.W.; Mangat, A.; Taylor, E.; Zhang, Z.; Goodman, S.; Argani, P.; Nayar, R.; Susnik, B.; Sukumar, S.; Khan, S.A. Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge. Clin Cancer Res. 2009 Jun 1;15(11):3802-3811.
    33. Higgins, J.P.; McKenney, J.K.; Brooks, J.D.; Argani, P.; Epstein, J.I. Recommendations for the reporting of surgically resected specimens of renal cell carcinoma: the Association of Directors of Anatomic and Surgical Pathology. Hum Pathol. 2009 Apr;40(4):456-463.
    34. Lo, P.K.; Watanabe, H.; Cheng, P.C.; Teo, W.W.; Liang, X.; Argani, P.; Lee, J.S.; Sukumar, S. MethySYBR, a novel quantitative PCR assay for the dual analysis of DNA methylation and CpG methylation density. J Mol Diagn. 2009 Sep;11(5):400-414.
    35. Martignoni, G.; Pea, M.; Gobbo, S.; Brunelli, M.; Bonetti, F.; Segala, D.; Pan, C.C.; Netto, G.; Doglioni, C.; Hes, O.; Argani, P.; Chilosi, M. Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas. Mod Pathol. 2009 Aug;22(8):1016-1022.
    36. McDonald, O.G.; Rodriguez, R.; Bergner, A.; Argani, P. Metanephric Stromal Tumor Arising in a Patient With the Neurofibromatosis Type 1 Syndrome. Int J Surg Pathol. 2009 Oct 28.
    37. Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.
    38. Sausville, J.E.; Hernandez, D.J.; Argani, P.; Gearhart, J.P. Pediatric renal cell carcinoma. J Pediatr Urol. 2009 Aug;5(4):308-314.
    39. Shi, C.; Chandrasekaran, A.; Thuluvath, P.J.; Karikari, C.; Argani, P.; Goggins, M.; Maitra, A.; Eshleman, J.R. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn. 2009 Nov;11(6):583-589.
    40. Subhawong, A.P.; Heaphy, C.M.; Argani, P.; Konishi, Y.; Kouprina, N.; Nassar, H.; Vang, R.; Meeker, A.K. The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression. Mod Pathol. 2009 Nov;22(11):1423-1431.
    41. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol. 2009 Feb;33(2):163-175.
    42. Cimino, A.; Halushka, M.; Illei, P.; Wu, X.; Sukumar, S.; Argani, P. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2010 Oct;123(3):701-708.
    43. Gupta, R.A.; Shah, N.; Wang, K.C.; Kim, J.; Horlings, H.M.; Wong, D.J.; Tsai, M.C.; Hung, T.; Argani, P.; Rinn, J.L.; Wang, Y.; Brzoska, P.; Kong, B.; Li, R.; West, R.B.; van de Vijver, M.J.; Sukumar, S.; Chang, H.Y. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010 Apr 15;464(7291):1071-1076.
    44. Jacobs, M.A.; Stearns, V.; Wolff, A.C.; Macura, K.; Argani, P.; Khouri, N.; Tsangaris, T.; Barker, P.B.; Davidson, N.E.; Bhujwalla, Z.M.; Bluemke, D.A.; Ouwerkerk, R. Multiparametric magnetic resonance imaging, spectroscopy and multinuclear ((2)(3)Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer. Acad Radiol. 2010 Dec;17(12):1477-1485.
    45. Lewis, G.H.; Subhawong, A.P.; Nassar, H.; Vang, R.; Illei, P.; Park, B.H.; Argani, P. Relationships between Molecular Subtype of Invasive Breast Carcinoma (IBC) and Expression of Gross Cystic Disease Fluid Protein 15 (GCDFP) and Mammaglobin (MGB). American Journal of Clinical Pathology. 2010;In Press.
    46. Lo, P.K.; Lee, J.S.; Liang, X.; Han, L.; Mori, T.; Fackler, M.J.; Sadik, H.; Argani, P.; Pandita, T.K.; Sukumar, S. Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer. Cancer Res. 2010 Jul 15;70(14):6047-6058.
    47. Ohm, J.E.; Mali, P.; Van Neste, L.; Berman, D.M.; Liang, L.; Pandiyan, K.; Briggs, K.J.; Zhang, W.; Argani, P.; Simons, B.; Yu, W.; Matsui, W.; Van Criekinge, W.; Rassool, F.V.; Zambidis, E.; Schuebel, K.E.; Cope, L.; Yen, J.; Mohammad, H.P.; Cheng, L.; Baylin, S.B. Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Res. 2010 Oct 1;70(19):7662-7673.
    48. Wu, J.M.; Halushka, M.K.; Argani, P. Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer. Hum Pathol. 2010 Jun;41(6):914-917.
    49. Heaphy, C.M.; Subhawong, A.P.; Gross, A.L.; Konishi, Y.; Kouprina, N.; Argani, P.; Visvanathan, K.; Meeker, A.K. Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes. Mod Pathol. 2011 Nov 5;24(2):194-200.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Arthur Purdy Stout Prize, United States and Canadian Academy of Pathology, 2007

    Professors’ Award for Excellence in Teaching, Johns Hopkins University School of Medicine, 2004

    Professional Activities

    Steering committee, Breast Center, Johns Hopkins University Medical School

    Editorial board, American Journal of Surgical Pathology

    Editorial board, American Journal of Clinical Pathology

    Editorial board, Modern Pathology

    Editorial board, International Journal of Surgical Pathology

    Web master, Bile Duct and Gallbladder Cancer Web

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-2660
    Location Map

    Department/Division

    • Pathology

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