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Lili Ayala Barouch, M.D.

Photo of Dr. Lili Ayala Barouch, M.D.

Associate Professor of Medicine


Expertise: Cardiomyopathy, Cardiovascular Disease, Cardiovascular Disease in Women, Cardiovascular Diseases, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Ischemic Heart Disease, Mechanical Circulatory Support, Pacemakers, Peripartum Cardiomyopathy more

Research Interests: Obesity and congestive heart failure; Leptin signaling and cardiac hypertrophy; Beta 3 adrenergic signaling and cardiac remodeling; Cardioprotective effect of beta-3 adrenergic receptor signaling more

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Johns Hopkins Cardiology - Columbia
Appointment Phone: 410-964-5303

5450 Knoll North Drive
Columbia, MD 21045 map
Phone: 410-502-0188

Johns Hopkins Outpatient Center
Appointment Phone: 443-997-0270

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-502-0188
Fax: 410-614-0384

The Johns Hopkins Hospital
Appointment Phone: 443-997-0270

600 N. Wolfe Street
Heart and Vascular Institute, Sheikh Zayed Tower, Suite 7107
Baltimore, MD 21287 map
Phone: 410-502-0188
Fax: 410-964-5329



  • MD, Johns Hopkins University School of Medicine (1996)


  • Johns Hopkins University School of Medicine / Internal Medicine (1999)


  • Johns Hopkins University School of Medicine / Cardiology (2003)

Board Certifications

  • American Board of Internal Medicine / Advanced Heart Failure and Transplant Cardiology (2010)
  • American Board of Internal Medicine / Cardiovascular Disease (2003, 2017)
  • American Board of Internal Medicine / Internal Medicine (1999)

Research & Publications


Dr. Barouch’s laboratory is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function. The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

Selected Publications

Original research papers

1. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RS, Lima JAC. The prognostic significance of microvascular obstruction by magnetic resonance imaging in patients in acute myocardial infarction. Circulation 97:765-772; 1998.

2. Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O''Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416:337-339; 2002.

3. Barouch LA, Cappola TP, Harrison RW, Crone JK, Burnett AL, Hare JM. Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. Journal of Molecular and Cellular Cardiology 35:637-644; 2003.

4. Cappola TP, Cope L, Cernetich A, Barouch LA, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JGN, Hare JM. Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy. Physiological Genomics 14:25-34; 2003.

5. Barouch LA, Berkowitz DE, Harrison RW, ODonnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108:754-759; 2003.

6. Townsend S, Jung A, Lemmon CA, Harrison RW, Li KH, Barouch LA, Cotecchia S, Shoukas A, Nyhan D, Hare JM, Berkowitz DE. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension 44:776-782; 2004.

7. Minhas KM, Khan SA, Raju SV, Phan AC, Gonzalez DR, Skaf MW, Lee K, Tejani AD, Saliaris AP, Barouch LA, ODonnell CP, Emala CW, Berkowitz DE, Hare JM. Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. Journal of Physiology 565:463-474; 2005.

8. Saraiva RM, Minhas KM, Raju SVY, Barouch LA, Pitz E, Schuleri KH, Vandegaer KM, Li D, Hare JM. Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: Role of nitroso-redox equilibrium. Circulation 112(22):3415-22; 2005.

9. Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MK, Minhas KM, Berkowitz DE, Wei C, Hare JM. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research 98(1):119-24; 2006.

10. Minhas KM, Saraiva RM, Schuleri KH, Lehrke S, Zheng M, Saliaris AP, Berry CE, Barouch LA, Vandegaer KM, Li D, Hare JM. Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy. Circulation Research 98(2):271-9; 2006.

11. Raju SVY, Zheng M, Schuleri KH, Phan AC, Bedja D, Saraiva RM, Yiginer O, Vandegaer K, Gabrielson KL, O''Donnell CP, Berkowitz DE, Barouch LA, Hare JM. Activation of the novel cardiac ciliary neurotrophic factor receptor reverses LVH in leptin deficient and leptin resistant obesity. Proceedings of the National Academy of Sciences USA. 103(11):4222-7; 2006.

12. Saraiva RM, Minhas KM, Zheng M, Pitz E, Treuer A, Gonzalez D, Schuleri KH, Vandegaer KM, Barouch LA, Hare JM. Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric Oxide 16(3):331-8; 2007.

13. Soong TR, Barouch LA, Champion HC, Wigley FM, Halushka MK. New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy-a report of 2 cases. Human Pathology. 38(12):1858-63; 2007.

14. Trivedi P, Yang R, Barouch LA. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell Cycle. 7(5):560-5; 2008.

Reviews (peer-reviewed)

1. Raju SVY, Barouch LA, Hare JM. Oxidative Stress and Aging Revisited: Nitric Oxide as a Key Modulator of Cardiovascular Aging. Sciences Aging Knowledge Environment 2005:re4; 2005.
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2. Yang R, Barouch LA. Leptin Signaling and Obesity: Cardiovascular Consequences, Circulation Research. 101(6):545-59; 2007.

3. Trivedi PS, Barouch LA. Cardiomyocyte apoptosis in animal models of obesity. Current Hypertension Reports. 10(6):454-60; 2008.

Activities & Honors


  • Trainee Abstract Award, American Heart Association Council on Basic Cardiovascular Sciences, 2001
  • 1st Place, Fellow Division, Mid-Atlantic Cardiovascular Research Competition, 2001
  • Bristol-Myers-Squibb Travel Award, American College of Cardiology Scientific Session, 2002
  • Finalist, Fellow Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2002
  • Trainee Best Poster Award, American Society for Clinical Investigation and American Academy of Physicians Joint Meeting, 2003
  • Fellow Basic Science Poster Award, and Facilitated Poster Session on Obesity/Metabolism, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2003
  • Finalist, Poster Competition in Basic Sciences, American Heart Association Scientific Sessions, 2004
  • Sponsored Young Investigator, GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Symposium: New Frontiers in Genomics and Cardiovascular Disease, 2005
  • Junior Faculty Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2005
  • Finalist, Northwestern Cardiovascular Forum Young Investigators Award, Junior Faculty Division, 2008


  • American College of Cardiology, 1999
  • American College of Cardiology Women in Cardiology Section, 2004
  • American Heart Association, 1999
  • American Heart Association Council on Basic Cardiovascular Sciences, 2001

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Heart Disease Doesn't Discriminate (news article)

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