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Derek Michael Fine, M.D.

Photo of Dr. Derek Michael Fine, M.D.

Director, Nephrology Fellowship Program

Associate Professor of Medicine

Male

Languages: English, Afrikaans

Expertise: Glomerulonephritis, HIV Related Kidney Disease, Kidney biopsy , Lupus Nephritis, Nephrology, Rhabdomyolysis, Scleroderma Related Kidney Disease ...read more

Research Interests: HIV kidney diseases; Lupus nephritis

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-0670

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Background

Dr. Derek M. Fine is an associate professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include nephrology, HIV- and scleroderma-related kidney disease, glomerulonephritis, kidney biopsy, lupus nephritis and rhabdomyolysis. Dr. Fine serves as the director of the Nephrology Fellowship Program.

Dr. Fine earned his M.D. at Johns Hopkins. He completed his residency and performed a fellowship in nephrology at Johns Hopkins.

His research interests include HIV-related kidney diseases and lupus nephritis.

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Titles

  • Director, Nephrology Fellowship Program
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Johns Hopkins University School of Medicine (1994)

Residencies

  • Johns Hopkins University School of Medicine / Internal Medicine (1997)

Fellowships

  • Johns Hopkins University School of Medicine / Nephrology (1999)

Board Certifications

  • American Board of Internal Medicine / Nephrology (2000, 2010)

Research & Publications

Research Summary

Dr. Fine’s research focuses on optimizing the diagnosis and management of glomerular kidney diseases, particularly those related to HIV and systemic lupus erythematosus (SLE).

Selected Publications

  1. Gregory M Lucas; Yuezhou Jing; Mark Sulkowski; Alison G Abraham; Michelle M Estrella; Mohamed G Atta; Derek M Fine; Marina B Klein; Michael J Silverberg; M John Gill; et al. Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. The Journal of infectious diseases 2013;208(8):1240-9. 2013
  2. Matthew C Foy; Michelle M Estrella; Gregory M Lucas; Faryal Tahir; Derek M Fine; Richard D Moore; Mohamed G Atta; Comparison of risk factors and outcomes in HIV immune complex kidney disease and HIV-associated nephropathy. Clinical journal of the American Society of Nephrology : CJASN 2013;8(9):1524-32. 2013
  3. Teresa K Chen; Derek M Fine; Top 10 developments in lupus nephritis. Current rheumatology reports 2013;15(9):358. 2013
  4. Derek M Fine; Joel E Gallant; Nephrotoxicity of antiretroviral agents: is the list getting longer? The Journal of infectious diseases 2013;207(9):1349-51. 2013
  5. Masahiro Ono; George J Arnaoutakis; Derek M Fine; Kenneth Brady; R Blaine Easley; Yueying Zheng; Charles Brown; Nevin M Katz; Morgan E Grams; Charles W Hogue; Blood pressure excursions below the cerebral autoregulation threshold during cardiac surgery are associated with acute kidney injury. Critical care medicine 2013;41(2):464-71. 2013
  6. Mohamed G Atta; Michelle M Estrella; Michael Kuperman; Matthew C Foy; Derek M Fine; Lorraine C Racusen; Gregory M Lucas; George W Nelson; Andrew C Warner; Cheryl A Winkler; et al. HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics. Kidney international 2012;82(3):338-43. 2012
  7. T K Chen; M M Estrella; D M Fine; Predictors of kidney biopsy complication among patients with systemic lupus erythematosus. Lupus 2012;21(8):848-54. 2012
  8. Matthew C Foy; Chloe L Thio; Hyon S Hwang; Melissa Saulynas; James P Hamilton; Derek M Fine; Mohamed G Atta; False-negative hepatitis B virus (HBV) surface antigen in a vaccinated dialysis patient with a high level of HBV DNA in the United States. Clinical and vaccine immunology : CVI 2012;19(5):820-2. 2012
  9. Derek M Fine; Walter G Wasser; Michelle M Estrella; Mohamed G Atta; Michael Kuperman; Revital Shemer; Arun Rajasekaran; Shay Tzur; Lorraine C Racusen; Karl Skorecki; APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease. Journal of the American Society of Nephrology : JASN 2012;23(2):343-50. 2012
  10. Michelle M Estrella; Gregory D Kirk; Shruti H Mehta; Todd T Brown; Derek M Fine; Mohamed G Atta; Gregory M Lucas; Vitamin D deficiency and persistent proteinuria among HIV-infected and uninfected injection drug users. AIDS (London, England) 2012;26(3):295-302. 2012
  11. Elizabeth George; Girish N Nadkarni; Michelle M Estrella; Gregory M Lucas; C John Sperati; Mohamed G Atta; Derek M Fine; The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): a biopsy study. Medicine 2011;90(5):289-95. 2011
  12. Joel N Blankson; Christie R Basseth; Michael Kuperman; Derek M Fine; Spontaneous resolution of HIV-associated nephropathy in an elite controller. AIDS (London, England) 2011;25(8):1135-7. 2011
  13. T Shafi; M J Choi; L C Racusen; L A Spacek; C Berry; M Atta; D M Fine; Ritonavir-induced acute kidney injury: kidney biopsy findings and review of literature. Clinical nephrology 2011;75 Suppl 1():60-4. 2011
  14. Gregory M Lucas; William Clarke; Joseph Kagaayi; Mohamed G Atta; Derek M Fine; Oliver Laeyendecker; David Serwadda; Michael Chen; Maria J Wawer; Ronald H Gray; Decreased kidney function in a community-based cohort of HIV-Infected and HIV-negative individuals in Rakai, Uganda. Journal of acquired immune deficiency syndromes (1999) 2010;55(4):491-4. 2010
  15. C M Lanata; T Mahmood; D M Fine; M Petri; Combination therapy of mycophenolate mofetil and tacrolimus in lupus nephritis. Lupus 2010;19(8):935-40. 2010
  16. Joshua F Zeidner; Edwin J Ostrin; Emily Sydnor; Derek Fine; C John Sperati; The tissue's the issue. The American journal of medicine 2010;123(5):420-2. 2010
  17. Shyam M Parkhie; Derek M Fine; Gregory M Lucas; Mohamed G Atta; Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis. Clinical journal of the American Society of Nephrology : CJASN 2010;5(5):798-804. 2010
  18. Elizabeth George; Gregory M Lucas; Girish N Nadkarni; Derek M Fine; Richard Moore; Mohamed G Atta; Kidney function and the risk of cardiovascular events in HIV-1-infected patients. AIDS (London, England) 2010;24(3):387-94. 2010
  19. Derek M Fine; Mark A Perazella; Nephrogenic systemic fibrosis: what the hospitalist needs to know. Journal of hospital medicine : an official publication of the Society of Hospital Medicine 2010;5(1):46-50. 2010
  20. Michelle M Estrella; Derek M Fine; Screening for chronic kidney disease in HIV-infected patients. Advances in chronic kidney disease 2010;17(1):26-35. 2010
  21. Evan J Lipson; Carol Ann Huff; Danniele G Holanda; Michael A McDevitt; Derek M Fine; Lenalidomide-induced acute interstitial nephritis. The oncologist 2010;15(9):961-4. 2010
  22. Derek M Fine; Martina Ziegenbein; Michelle Petri; Ernest C Han; Alison M McKinley; Jerry W Chellini; Haikady N Nagaraja; Kathryn A Carson; Brad H Rovin; A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis. Kidney international 2009;76(12):1284-8. 2009
  23. Sayed Tabatabai; C John Sperati; Mohamed G Atta; Kashif Janjua; Christopher Roxbury; Gregory M Lucas; Derek M Fine; Predictors of complication after percutaneous ultrasound-guided kidney biopsy in HIV-infected individuals: possible role of hepatitis C and HIV co-infection. Clinical journal of the American Society of Nephrology : CJASN 2009;4(11):1766-73. 2009
  24. Kimberly Y Smith; Parul Patel; Derek Fine; Nicholaos Bellos; Louis Sloan; Philip Lackey; Princy N Kumar; Denise H Sutherland-Phillips; Cindy Vavro; Linda Yau; et al. Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment. AIDS (London, England) 2009;23(12):1547-56. 2009
  25. Mohamed G Atta; Derek M Fine; Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice. The AIDS reader 2009;19(3):118-9. 2009
  26. Javier Perez-Rodriguez; Shenghan Lai; Benjamin D Ehst; Derek M Fine; David A Bluemke; Nephrogenic systemic fibrosis: incidence, associations, and effect of risk factor assessment--report of 33 cases. Radiology 2009;250(2):371-7. 2009
  27. Derek M Fine; Agnes B Fogo; Charles E Alpers; Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient. Seminars in nephrology 2008;28(6):545-55. 2008
  28. Michelle Petri; Nuntana Kasitanon; Sukminder Singh; Kimberly Link; Laurence Magder; Sang-Cheol Bae; John G Hanly; Ola Nived; Gunnar Sturfelt; Ronald van Vollenhoven; et al. Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response. Arthritis and rheumatism 2008;58(6):1789-95. 2008
  29. Michelle Petri; Nuntana Kasitanon; Shin-Seok Lee; Kimberly Link; Laurence Magder; Sang-Cheol Bae; John G Hanly; David A Isenberg; Ola Nived; Gunnar Sturfelt; et al. Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index. Arthritis and rheumatism 2008;58(6):1784-8. 2008
  30. Mohamed G Atta; Gregory M Lucas; Derek M Fine; HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management. Expert review of anti-infective therapy 2008;6(3):365-71. 2008
  31. Gregory M Lucas; Bryan Lau; Mohamed G Atta; Derek M Fine; Jeanne Keruly; Richard D Moore; Chronic kidney disease incidence, and progression to end-stage renal disease, in HIV-infected individuals: a tale of two races. The Journal of infectious diseases 2008;197(11):1548-57. 2008
  32. Derek M Fine; Mark A Perazella; Gregory M Lucas; Mohamed G Atta; Kidney biopsy in HIV: beyond HIV-associated nephropathy. American journal of kidney diseases : the official journal of the National Kidney Foundation 2008;51(3):504-14. 2008
  33. Douglas R Linfert; Jane O Schell; Derek M Fine; Treatment of nephrogenic systemic fibrosis: limited options but hope for the future. Seminars in dialysis 2008;21(2):155-9. 2008
  34. Mark J Siedner; Mohamed G Atta; Gregory M Lucas; Mark A Perazella; Derek M Fine; Poor validity of urine dipstick as a screening tool for proteinuria in HIV-positive patients. Journal of acquired immune deficiency syndromes (1999) 2008;47(2):261-3. 2008
  35. Derek M Fine; Mark A Perazella; Gregory M Lucas; Mohamed G Atta; Renal disease in patients with HIV infection: epidemiology, pathogenesis and management. Drugs 2008;68(7):963-80. 2008
  36. Mark J Siedner; Allan C Gelber; Brad H Rovin; Alison M McKinley; Lisa Christopher-Stine; Brad Astor; Michelle Petri; Derek M Fine; Diagnostic accuracy study of urine dipstick in relation to 24-hour measurement as a screening tool for proteinuria in lupus nephritis. The Journal of rheumatology 2008;35(1):84-90. 2008
  37. N Kasitanon; M Petri; M Haas; L S Magder; D M Fine; Mycophenolate mofetil as the primary treatment of membranous lupus nephritis with and without concurrent proliferative disease: a retrospective study of 29 cases. Lupus 2008;17(1):40-5. 2008
  38. Adam R Berliner; Derek M Fine; Gregory M Lucas; M Hafizur Rahman; Lorraine C Racusen; Paul J Scheel; Mohamed G Atta; Observations on a cohort of HIV-infected patients undergoing native renal biopsy. American journal of nephrology 2008;28(3):478-86. 2008
  39. Mohamed G Atta; Derek M Fine; Gregory D Kirk; Shruti H Mehta; Richard D Moore; Gregory M Lucas; Survival during renal replacement therapy among African Americans infected with HIV type 1 in urban Baltimore, Maryland. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(12):1625-32. 2007
  40. Derek M Fine; Mohamed G Atta; Kidney disease in the HIV-infected patient. AIDS patient care and STDs 2007;21(11):813-24. 2007
  41. Derek M Fine; Neha Garg; Mark Haas; M Hafizur Rahman; Gregory M Lucas; Paul J Scheel; Mohamed G Atta; Cocaine use and hypertensive renal changes in HIV-infected individuals. Clinical journal of the American Society of Nephrology : CJASN 2007;2(6):1125-30. 2007
  42. Alexandre Benjo; Richard E Thompson; Derek Fine; Charles W Hogue; Diane Alejo; Anita Kaw; Gary Gerstenblith; Ashish Shah; Dan E Berkowitz; Daniel Nyhan; Pulse pressure is an age-independent predictor of stroke development after cardiac surgery. Hypertension 2007;50(4):630-5. 2007
  43. Derek M Fine; Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function. The AIDS reader 2007;17(6):326-7. 2007
  44. Mark J Siedner; Lisa Christopher-Stine; Brad C Astor; Allan C Gelber; Derek M Fine; Screening for proteinuria in patients with lupus: a survey of practice preferences among American rheumatologists. The Journal of rheumatology 2007;34(5):973-7. 2007
  45. Lisa Christopher-Stine; Mark Siedner; Janice Lin; Mark Haas; Hemal Parekh; Michelle Petri; Derek M Fine; Renal biopsy in lupus patients with low levels of proteinuria. The Journal of rheumatology 2007;34(2):332-5. 2007
  46. Julia J Scialla; Mohamed G Atta; Derek M Fine; Relapse of HIV-associated nephropathy after discontinuing highly active antiretroviral therapy. AIDS (London, England) 2007;21(2):263-4. 2007
  47. N Kasitanon; D M Fine; M Haas; L S Magder; M Petri; Estimating renal function in lupus nephritis: comparison of the Modification of Diet in Renal Disease and Cockcroft Gault equations. Lupus 2007;16(11):887-95. 2007
  48. Derek M Fine; Renal disease and toxicities: issues for HIV care providers. Topics in HIV medicine : a publication of the International AIDS Society, USA 2006;14(5):164-9. 2006
  49. Mohamed G Atta; Joel E Gallant; M Hafizur Rahman; Nagapradeep Nagajothi; Lorraine C Racusen; Paul J Scheel; Derek M Fine; Antiretroviral therapy in the treatment of HIV-associated nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(10):2809-13. 2006
  50. Michelle Estrella; Derek M Fine; Joel E Gallant; M Hafizur Rahman; Nagapradeep Nagajothi; Lorraine C Racusen; Paul J Scheel; Mohamed G Atta; HIV type 1 RNA level as a clinical indicator of renal pathology in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(3):377-80. 2006
  51. Geoffrey R Bihl; Michelle Petri; Derek M Fine; Kidney biopsy in lupus nephritis: look before you leap. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(7):1749-52. 2006
  52. Hyun S Kim; Derek M Fine; Mohamed G Atta; Catheter-directed thrombectomy and thrombolysis for acute renal vein thrombosis. Journal of vascular and interventional radiology : JVIR 2006;17(5):815-22. 2006
  53. N Kasitanon; D M Fine; M Haas; L S Magder; M Petri; Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis. Lupus 2006;15(6):366-70. 2006
  54. Mohamed G Atta; Michael J Choi; J Craig Longenecker; Megan Haymart; Jean Wu; Nagapradeep Nagajothi; Lorraine C Racusen; Paul J Scheel; Frederick L Brancati; Derek M Fine; Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy. The American journal of medicine 2005;118(11):1288. 2005
  55. Derek M Fine; Editorial comment: tenofovir nephrotoxicity--vigilance required. The AIDS reader 2005;15(7):362-3. 2005
  56. Derek M Fine; Pharmacological therapy of lupus nephritis. JAMA : the journal of the American Medical Association 2005;293(24):3053-60. 2005
  57. Gürkan Sengoelge; Wensheng Luo; Derek Fine; Agnes M Perschl; Wolfgang Fierlbeck; Abdolreza Haririan; Jenny Sorensson; Tausif-Ur Rehman; Peter Hauser; Jacob S Trevick; et al. A SAGE-based comparison between glomerular and aortic endothelial cells. American journal of physiology. Renal physiology 2005;288(6):F1290-300. 2005
  58. N Dasgupta; A C Gelber; F Racke; D M Fine; Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. Lupus 2005;14(11):910-3. 2005
  59. Derek M Fine; Allan C Gelber; Michal L Melamed; Janice C Lin; Lin Zhang; Joseph A Eustace; Risk factors for renal failure among 72 consecutive patients with rhabdomyolysis related to illicit drug use. The American journal of medicine 2004;117(8):607-10. 2004
  60. Davinder S Grover; Mohamed G Atta; Joseph A Eustace; Thomas S Kickler; Derek M Fine; Lack of clinical utility of urine myoglobin detection by microconcentrator ultrafiltration in the diagnosis of rhabdomyolysis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(10):2634-8. 2004
  61. Lisa Christopher-Stine; Michelle Petri; Brad C Astor; Derek Fine; Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis. The Journal of rheumatology 2004;31(8):1557-9. 2004
  62. Derek M Fine; Aravind Arepally; Lawrence V Hofmann; Steven G Mankowitz; Mohamed G Atta; Diagnostic utility and safety of transjugular kidney biopsy in the obese patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(7):1798-802. 2004
  63. Allan C Gelber; Lisa Christopher-Stine; Derek M Fine; Sequential therapies for proliferative lupus nephritis. The New England journal of medicine 2004;350(24):2518-20; author reply 2518-20. 2004
  64. Mohamed G Atta; J Craig Longenecker; Derek M Fine; Nagapradeep Nagajothi; Davinder S Grover; Jean Wu; Lorraine C Racusen; Paul J Scheel; Ulrike M Hamper; Sonography as a predictor of human immunodeficiency virus-associated nephropathy. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2004;23(5):603-10; quiz 612-3. 2004
  65. Kyrsten D Fairbanks; Joseph A Eustace; Derek Fine; Paul J Thuluvath; Renal function improves in liver transplant recipients when switched from a calcineurin inhibitor to sirolimus. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(10):1079-85. 2003
  66. Attaphol Pawarode; Derek M Fine; Paul J Thuluvath; Independent risk factors and natural history of renal dysfunction in liver transplant recipients. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003;9(7):741-7. 2003
  67. D M Fine; C F Lo; L Aguillar; D L Blackmon; M H Montrose; Cellular chloride depletion inhibits cAMP-activated electrogenic chloride fluxes in HT29-18-C1 cells. The Journal of membrane biology 1995;145(2):129-41. 1995
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