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Dean Frederick MacKinnon, MD

Associate Professor of Psychiatry and Behavioral Sciences
Appointment Phone


Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Associate Professor of Psychiatry and Behavioral Sciences

Centers & Institutes

  • Mood Disorders Center


Adult Psychiatry, Affective Disorders, Bipolar Disorder, Depression, Mood Disorders, Psychiatry

Research Interests

bipolar disorder endophenotypes


My clinical interest is in the evaluation and treatment of patients with complex and treatment refractory depression, manic depressive illness, and anxiety. My research interest revolves around the problem of identifying the phenotypic boundaries of bipolar disorder(s). Specifically, I have identified panic disorder and rapid switching as phenomenological features of bipolar illness that may lead to biologically meaningful subtypes. I am also interested in the psychophysiology of anxiety as it relates to mood disorders. Most of my time and energy for teaching is devoted to running the first year psychiatry course.


  • English


American Psychiatric Association, General Member, 1996-present
Maryland Psychiatric Society, 1991-present
Residents Committee, 1992-94
Public Affairs Committee, 1994-95
American Psychopathological Association, Member, 2000-present
Association for Directors of Medical Student Education in Psychiatry, 2007-present

Additional Resources

Additional Resources +
  • Education +


    • University of California San Diego School of Medicine (La Jolla CA ) (1990)


    • Psychiatry, American Board of Psychiatry & Neurology (2005)
  • Research & Publications +

    Selected Publications

    Selected 1st and Senior Author Publications

    1. MacKinnon DF, Squire LR, "Autobiographical Memory and Amnesia," Psychobiology 1989; 17:247-256. 
    2. MacKinnon DF, McMahon FJ, Simpson SG, McInnis MG, DePaulo JR, "Panic Disorder with Familial Bipolar Disorder," Biological Psychiatry 1997; 42:90-95.
    3. MacKinnon DF, Jamison KR, DePaulo JR, "Genetics of Manic Depressive Illness," Annual Review of Neuroscience 1997; 20:355-73. 
    4. MacKinnon DF, Affective Disorders, Encyclopaedia of Stress, Fink, G, Academic Press (2000).
    5. MacKinnon, DF, The Patient Thinking of Suicide, Common Psychiatric and Neurologic Problems in Primary Care, Hurko O and Slavney PR, eds., Johns Hopkins University Press (2001).
    6. MacKinnon DF and DePaulo JR, Disorders of Mood, Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles, 3rd edition, Ashbury AK, McKhann G, McDonald WI, Goadsby PJ, McArthur JC, eds., Cambridge University Press (2002).
    7. MacKinnon DF and Hoehn-Saric R, Is There a Common Etiology for Depression and Anxiety? Handbook of Anxiety and Depression, Kasper S, den Boer JA, Sitsen JMA, eds., Marcel Dekker, NY (2003).
    8. MacKinnon DF, Zandi PP, Cooper J, Potash JB, Simpson SG, Gershon E, Nurnberger J, Reich T, DePaulo JR. Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder. Am J Psychiatry 2002; 159:30-5.
    9. MacKinnon DF, Zandi PP, Gershon E, Nurnberger JI Jr., Reich T, DePaulo JR. Rapid switching of mood in families with multiple cases of bipolar disorder, Arch Gen Psychiatry 2003; 60:921-928.
    10. MacKinnon, DF and Pies, R. Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders. Bipolar.Disord. 2006; 8:1-14 
    11. MacKinnon, DF and Zamoiski, R. Panic comorbidity with bipolar disorder: what is the manic-panic connection? Bipolar.Disord 2006; 8:648-64 
    12. MacKinnon, D. F., Craighead, B, and Hoehn-Saric, R. Carbon Dioxide Provocation of Anxiety and Respiratory Response in Bipolar Disorder. J Affect Disord 2007; 99:45-9
    13. Nwulia EA, Zandi PP, McInnis MG, DePaulo JR, MacKinnon DF. Rapid Switching of Mood in Families With Familial Bipolar Disorder. Bipolar Disord 2008 10:597-606.
    14. MacKinnon DF. Bipolar Diosrder as Maladaptive Arousal: A Behavioral Model and Evidence. Annals of the NY Academy of Science 2008 1129:185-9.
    15. MacKinnon DF, Craighead B, Lorenz L. Carbon dioxide induces erratic respiratory responses in bipolar disorder. J Affect Disord 2009 112:193-200.

    Other media:

    1. National Coalition for Health Professional Education in Genetics. Genetics and Major Psychiatric Disorders: A Program for Genetic Counselors, CD-ROM, 2002.
    2. Development of a problem and function-based preclinical psychiatry course. Poster presentation for annual meeting of the Association for Directors of Medical Student Education in Psychiatry (ADMSEP), June 2009.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Introduction to Psychiatry and Behavioral Sciences 2001-present, course director
    Senior Psychiatric Resident Seminar Series
    1998-2001; course organizer
    Psychiatric Clerkship Lecture 1996-present, lecturer (twice per year)

    Clinical instruction:
    Psychiatric inpatient services; 1996-present: student, and house-staff
    Affective Disorders Outpatient (Resident) Clinic; 1998-present;
    Psychiatric Ambulatory (Resident) Clinic; 1996-present.

    American Board of Psychiatry and Neurology 4/95-12/15, #41044

    Service Responsibilities
    Affective Disorders Inpatient Service (11-bed subspecialty inpatient unit)
    1996-present, 2-3 months/year; Attending Psychiatrist
    Affective Disorders Consultation Clinic
    1996-present, 2-3 consults/month; Attending Psychiatrist
    Chronic Pain Inpatient Service (8 bed subspecialty inpatient unit)
    2006-present, 1-2 months/year, Attending Psychiatrist
    Electroconvulsive Therapy
    1996-present, 1-2 months/year, Attending Psychiatrist
    General Hospital Psychiatry (consultation service)
    2008-present, 1 month/year, Attending Psychiatrist

  • Videos & Media +
  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Baltimore, MD 21287
    Phone: 443-287-6330
    Appointment Phone: 410-955-5212
    Fax: 410-955-0152
    Location Map


    • Psychiatry and Behavioral Sciences

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