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Adrian Sandra Dobs, MD

Director, Johns Hopkins Clinical Reserach Network
Professor of Medicine
Female
Appointment Phone

410-955-9270

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Johns Hopkins Clinical Reserach Network
  • Director, Johns Hopkins - SYSU (China) Collaboration
  • Vice-Chair Department of Medicine for Faculty Development
  • Director - Johns Hopkins Center to Reduce Cancer Disparities
  • Professor of Medicine
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Diabetes Mellitus, Endocrinology, HIV-Associated Metabolic Abnormalities, Hyperlipidemia, Male Testosterone Disorders, Polycystic Ovarian Disease, Sex Hormone Disorders

Research Interests

Endocrinology, Gonadal dysfunction, hyperlipidemia, diabetes mellitus

Biography

Dr. Dobs is presently an active investigator in the field of male gonadal function. She is particularly interested in new forms of male hormone replacement therapy and has published extensively in the area of hormonal changes with aging. As Director of the Clinical Trials Unit, she oversees a team of individuals dedicated to facilitating clinical research within an academic medical center environment.

Languages

  • English

Memberships

1987 The Endocrine Society
1994 American Andrology Society
2000 Institute of Medicine Roundtable in Clinical Research

Clinical Trial Keywords

  • Hormone replacement therapy men and women, hyperlipidemia, diabetes

Additional Resources

Additional Resources +
  • Education +

    Training

    • Albany Medical College of Union University ( Albany NY) (1978)

    Certifications

    • American Board of Internal Medicine / Endocrinology and Metabolism (1987)
    • American Board of Internal Medicine / Internal Medicine (1981)
  • Research & Publications +

    Research Summary

    Dr. Dobs is presently an active investigator in the field of sex hormone disorders and a clinical investigator who has published extensively in HIV-related endocrinopathies and risks and benefits of testosterone replacement therapies.

    Selected Publications

    Research Support.

    Ongoing Research Support:
    RO1 DA1409801 (Dobs AS) 06/15/03 05/31/09
    NIDA/NIH Cognitive Consequences of Endocrine Dysfunction in Injection Drug Users
    Role: Principal Investigator
    The major goal of this project is to investigate the consequences of hypogonadal endocrine dysfunction in injection drug users with and without HIV.

    2U01 AI35042-07 (Margolick JB) 04/01/04 03/31/11
    NIAID/NIH Multi-Center AIDS Cohorts
    Role: Co-Investigator
    The major goal of this project is to determine metabolic abnormalities of HIV disease.

    R03DA026038 09/30/08 9/29/10
    Serum Sex Hormones and Cardiovascular Risk in the MACS
    The major goal of this project is to study the relationship of sex steroids to heart disease
    Principal Investigator

    Publications

    1. Paller CJ, Shiels MS,Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A, Relationship of Sex Streriod Hormones with Bone Mineral Density in a Nationally-Representative Sample of Men, Clin Endocrinol (Oxf) May 2008 (E-pub ahead of print) PMID 18485120

    2. Wohl D, Scherzer R, Heymensfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C:FRAM Study Investigators (including Dobs A), The Associations of Regional Adipose Tissue with Lipid and Lipoprotein Levels in HIV Infected Men, J Aquir Immune Defic Syndr. , May 2008 48 (1):44-52.

    3. Brown T, Jacobson L, Xu X, Tang Y, Qaqish R, Kingsley L, Palella F, Witt M, Visscher B, Dobs A, The Relationship Between Inflammatory Markers, the Metabolic Syndrome and Body Composition Among HIV Seropositive and Seronegative Men: Two Nested Case-Control Studies from the Multicenter AIDS Cohort Study, Conference on Retroviruses and Oppurtunistic Infections.

    4. Dobs A, Mortgentaler A, Does Testosterone Therapy Increase the Risk of Prostate Cancer?Endocr.Prac.,2008,14,7,904-911 PMID 18996823
    Eckman A, Dobs A, Drug-Induced Gynecomastia,Expert Opin.Drug Saf..,2008,7,6,691-702, England PMID 18983216

    5. Mortgentaler A, Dobs AS, Kaufman JM, Miner MM, Shsbsigh R, Swerdloff, RS, Wang C. Long Acting Testosterone Therapyin Men with Hypogonadism: Results of a Pharmacokinetic Clinical Study, JUrol.,2008,180,6,2307-2313,United States, PMID 18930255

    6. Ouyang P, Vaidya D, Dobs A, Golden S, Szklo M, Heckbert S, Kopp P, Gapstur S, Sex Hormone Levels and Subclinical Atherosclerosis , Atherosclerosis, 2008 PMID 18849030

    7. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, Dobs A, Brown T, BMC Complementary and Alternative Medicine.,2008,8,50,England, PMID 18713456

    8. Vaidya D, Dobs A, Gapstur S, Golden S, Hankinson A, Liu K, Ouyang P, The Association of Endogenous Sex Hormones with Lipoprotein Subfraction Profile in the Multi-Ethnic Study of Atheroschlerosis, Metabolism, 2008,57,6,782-790, United States, PMID 18502260

    9. Pfeil E., Dobs A, Current and Future Testosterone Delivery Systems for Treatment of the Hypogonadal Male, Expert Opin. Drug Deliv., 2008 5,4,471-481, England, PMID 18426387

    10. Cofrancesco J, Scherzer R, Tien P, Gilbert C, Southwell H, Sidney S, Dobs A, Grunfeld C, Illicit Drug Use and HIV Treatment Outcomes in a US Cohort, AIDS,2008,22,3,357-365, England, PMID 18195562

    Journal Citations

    Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006 Feb 1;106(3):581-588.

    Braga-Basaria, M.; Dobs, A.S.; Muller, D.C.; Carducci, M.A.; John, M.; Egan, J.; Basaria, S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006 Aug 20;24(24):3979-3983.

    Braga-Basaria, M.; Muller, D.C.; Carducci, M.A.; Dobs, A.S.; Basaria, S. Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy. International journal of impotence research. 2006 Sep-Oct;18(5):494-498.

    Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.

    Maggio, M.; Blackford, A.; Taub, D.; Carducci, M.; Ble, A.; Metter, E.J.; Braga-Basaria, M.; Dobs, A.; Basaria, S. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006 Nov-Dec;27(6):725-728.

    Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Archives of internal medicine. 2007 Mar 26;167(6):612-613.

    Rohrmann, S.; Nelson, W.G.; Rifai, N.; Brown, T.R.; Dobs, A.; Kanarek, N.; Yager, J.D.; Platz, E.A. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab. 2007 Jul;92(7):2519-2525.

    Selvin, E.; Feinleib, M.; Zhang, L.; Rohrmann, S.; Rifai, N.; Nelson, W.G.; Dobs, A.; Basaria, S.; Golden, S.H.; Platz, E.A. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-238.

    Paller, C.J.; Shiels, M.S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W.; Platz, E.A.; Dobs, A. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology. 2009 Jan;70(1):26-34.

    Sharma, P.; Wisniewski, A.; Braga-Basaria, M.; Xu, X.; Yep, M.; Denmeade, S.; Dobs, A.S.; DeWeese, T.; Carducci, M.; Basaria, S. Lack of an effect of high dose isoflavones in men with prostate cancer undergoing androgen deprivation therapy. J Urol. 2009 Nov;182(5):2265-2272.

    Shiels, M.S.; Rohrmann, S.; Menke, A.; Selvin, E.; Crespo, C.J.; Rifai, N.; Dobs, A.; Feinleib, M.; Guallar, E.; Platz, E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009 Aug;20(6):877-886.

    Menke, A.; Guallar, E.; Rohrmann, S.; Nelson, W.G.; Rifai, N.; Kanarek, N.; Feinleib, M.; Michos, E.D.; Dobs, A.; Platz, E.A. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010 Mar 1;171(5):583-592.

    Mondul, A.M.; Selvin, E.; Rohrmann, S.; Menke, A.; Feinleib, M.; Kanarek, N.; Rifai, N.; Dobs, A.S.; Platz, E.A. Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III. Cancer Causes Control. 2010 Oct;21(10):1575-1583.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Positions and Employment:
    1978-1981 Medical Residency, Internal Medicine, Montefiore Hospital Medical Center,
    Albert Einstein College of Medicine, Bronx, NY
    1981-1982 Chief Resident, Internal Medicine, Montefiore Hospital Medical Center,
    Albert Einstein College of Medicine, Bronx, NY
    1982-1984 Endocrinology Fellow, Johns Hopkins University School of Medicine, Baltimore, MD
    1984-1987 Instructor, Division of Endocrinology and Metabolism, Johns Hopkins University
    1987-1993 Assistant Professor of Medicine, Johns Hopkins University School of Medicine
    1993-2000 Associate Professor of Medicine, The Johns Hopkins University School of Medicine
    1996-2001 Vice-Chair Department of Medicine Clinical Research, School of Medicine, Baltimore, MD
    1998-present Director, Clinical Trials Unit of Johns Hopkins School of Medicine
    2000-present Professor of Medicine and Oncology, Johns Hopkins University School of Medicine
    2001-2007 Director, Johns Hopkins Center for Complementary and Alternative Medicine
    2001-present Vice-Chair Department of Medicine Faculty Development, Johns Hopkins University School of Medicine, Baltimore, MD
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    1830 Monument Street Room 328
    Baltimore, MD 21287
    Phone: 410-955-3663
    Appointment Phone: 410-955-9270
    Fax: 410-955-8172
    Location Map

    Department/Division

    • Medicine - Endocrinology, Diabetes, & Metabolism

    For Research Inquiries Contact

    Robyn Hinke 443-287-4000

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