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Shawn Edward Lupold, Ph.D.

Photo of Dr. Shawn Edward Lupold, Ph.D.

Co-Director, The Sidney Kimmel Comprehensive Cancer Center Prostate Cancer Program

Associate Professor of Urology

Expertise: Urological Oncology

Research Interests: Viral gene/drug delivery; Targeting; Non-viral gene/drug delivery; Nanoparticles; Molecular imaging; Membrane proteins; Magnetic particles; Gene/drug delivery; Directed evolution; Radiation oncology; Urological oncology; Prostate cancer; Cancer ...read more

Contact for Research Inquiries

600 N Wolfe St.
Park 209
Baltimore, MD 21287 map

Background

Dr. Lupold is an associate professor of urology and oncology at the Johns Hopkins School of Medicine and co-director of the Prostate Cancer Program for the Sidney Kimmel Comprehensive Cancer Center. He is the inaugural Hinman Urologic Education Endowed Fund Scholar in the James Buchanan Brady Urological Institute.

Dr. Lupold is a researcher who specializes in cancer, molecular and cellular biology. His laboratory investigates the biology of prostate cancer with the goal of developing new, prostate-tissue-specific agents for diagnosing, predicting and treating the disease.

He also has a secondary appointment in the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins and is a member of the Johns Hopkins Institute for NanoBioTechnology. He also leads the Molecular Biology Core for Small Animal Imaging Resources Program. He joined the Johns Hopkins faculty in 2005.

Dr. Lupold earned his Ph.D. in pharmacology and molecular sciences from the Johns Hopkins University School of Medicine.

He was trained as a Pre-Intramural Research Training Award (IRTA) Fellow in the Laboratory of Human Carcinogenesis at the National Cancer Institute.

He completed a postdoctoral fellowship in prostate cancer research at the Brady Urological Institute. He also holds a B.S. in biology from the University of Maryland.

...read more

Titles

  • Co-Director, The Sidney Kimmel Comprehensive Cancer Center Prostate Cancer Program
  • The Hinman Urologic Education Endowed Fund Scholar in Urology
  • Director, Molecular Biology Core for Small Animal Imaging Resources Program
  • Associate Professor of Urology
  • Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Oncology

Education

Degrees

  • B.S., University of Maryland (College Park) (Maryland) (1992)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2001)

Additional Training

Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2005, Post-Doctoral Fellowship; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, 1995, Pre-Intramural Research Training Award (IRTA) Fellowship

Research & Publications

Research Summary

The Lupold laboratory focuses on prostate cancer biology with the goal of exploiting prostate tissue-specificity to develop new diagnostic, prognostic and therapeutic agents.

Research projects stem from basic cancer biology—such as studying the role of microRNAs in the prostate cancer phenotype—to translational projects, such as targeted siRNA and gene therapy.

One area of interest is high-diversity polymer libraries, including aptamers and peptides, which can be screened to identify high-affinity cancer ligands.

Using this approach, Dr. Lupold developed the first RNA aptamers targeted to a cancer cell-surface antigen. He and others have applied these PSMA-targeting aptamers to deliver various therapeutic and imaging packages to prostate cancer cells and tumors.

Dr. Lupold is involved in additional research projects that focus on prostate cancer biology and developing experimental diagnostic and therapeutic agents for urologic cancers.

He also co-holds four patents related to his research.

Lab Website: Shawn Lupold Laboratory

Selected Publications

View all on Pubmed

Lupold SE., Hicke B.J., Lin Y., Coffey DS. Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Research. 62(14):4029-33, 2002.

An androgen receptor regulated microRNA which promotes hormone dependent and independent prostate cancer growth. Cancer Research. 69(18): 7165-9, 2009. PMCID: PMC2861586.

Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi1 AH, Chowdhury WE, Kudrolli TA, Yegnasubramanian A, Luo J, Rodriguez T, Mendell JT, Lupold SE. miR-23.Ni X, Zhang Y, Ribas J, Chowdhury WH, Castanares M, Zhang Z, Laiho M, DeWeese TL, Lupold SE. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. Journal of Clinical Investigation. J Clin Invest. 2011 Jun 1; 121(6):2383-90. PMCID: PMC3104752

Ribas J*, Ni X*, Castanares M, Liu M, Rodriguez R, Mendell JT, and Lupold SE. A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts. Nucleic Acids Res. 2012 Aug 1;40(14):6821-33. PMCID: PMC3413119

Hatano K, Kumar B, Zhang Y, Coulter JB, Hedayati M, Mears B, Ni X, Kudrolli TA, Chowdhury WH, Rodriguez R, DeWeese TL, and Lupold SE. A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation. Nucleic Acids Res 2015 Apr 30;43(8):4075-86. PMCID: PMC4417178

Patents

Compositions and methods for detecting and quantifying circulating tumor cells (CTCs)
Patent # USPA 20140017668

Compositions and methods for retargeting virus constructs
Patent # USPA 20130315870

Radiation sensitization agents for prostate cancer
Patent # 20130123566

Compositions and methods for generating and screening adenoviral libraries
Patent # USPA 20090074658

Adenoviral fiber exchange shuttle system
Patent # US 8,088,621

Peptides for Targeting the Prostate Specific Membrane Antigen
Patent # US 7,749,986

Nucleic Acid Ligands to the Prostate Specific Membrane Antigen
Patent # US 6,933,114

Activities & Honors

Honors

  • Phyllis and Brian L. Harvey Scholar, 2009
  • Society for Basic Urologic Research Young Investigator Award, 2009
  • Department of Defense PCRP New Investigator Award, 2008
  • BioVision.Nxt Fellow, 2007
  • Virginia and Warren Schwerin Scholar, 2006
  • CPDR Distinguished Lecturer, 2005
  • Prostate Cancer Foundation Career Development Award, 2004
  • Pre-doctoral Intramural Research Training Award (IRTA), 1993

Memberships

  • American Association for Cancer Research, 1999
  • American Society of Gene and Cell Therapy, 2003
  • Society for Basic Urologic Research, 2006

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