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Xu Cao, Ph.D.

Photo of Dr. Xu Cao, Ph.D.

Lee Riley Professor, Department of Orthopaedic Surgery

Professor of Orthopaedic Surgery

Research Interests: Osteoarthritis; Osteoporosis; Bone remodeling; Mesenchymal stem cells

Background

Dr. Xu Cao is a professor of orthopaedic surgery at Johns Hopkins School of Medicine. His research focuses on the role of bone marrow mesenchymal stem cells (MSCs) in bone remodeling, osteoporosis and osteoarthritis.

Dr. Cao is the Lee Riley Professor in the Department of Orthopaedic Surgery and serves as the director of the Center for Musculoskeletal Research at the Johns Hopkins School of Medicine.

In researching osteoarthritis, his lab discovered that the bone underneath the cartilage plays a key role in the disease, and that blocking the action of a bone protein in mice halts its progression.

His team is currently researching the mechanism of coupling bone resorption and formation, MSCs in subchondral bone remodeling and osteoarthritis and the role of Smad1 in osteoblast differentiation of MSCs.

Dr. Cao earned his Ph.D. in chemistry and biochemistry from the University of South Carolina. He completed postdoctoral training in bone biology at Washington University in St. Louis, Missouri. Dr. Cao joined the Johns Hopkins faculty in 2009.

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Titles

  • Lee Riley Professor, Department of Orthopaedic Surgery
  • Director, Center for Musculoskeletal Research
  • Professor of Orthopaedic Surgery

Departments / Divisions

Education

Degrees

  • B.S., Xinjiang University (China) (1978)
  • Ph.D., University of South Carolina (Columbia) (South Carolina) (1988)

Additional Training

Washington University, St. Louis, MO, 1996, Bone Biology

Research & Publications

Research Summary

Bone marrow mesenchymal stem cells have the potential to differentiate to lineages of mesenchymal tissues, including osteoblasts, adipocytes, chondrocytes, fibroblasts and myoblasts. Dr. Cao studies the microenvironment that is necessary for differentiation of the multipotential stem cells into functionally distinct cell types such as osteoblasts. Parathyroid hormone and TGFß1 are the important factors that regulate the fate of mesenchymal stem cells. The primary goal of Dr. Cao’s research is to study the role of bone marrow mesenchymal stem cells in bone remodeling, osteoporosis and osteoarthritis.

Lab

The Cao lab studies the regulation of bone marrow mesenchymal stem cell lineage commitment. Dr. Cao and his research team found that TGFß1 induces mesenchymal stem cell migration to couple bone resorption and formation during bone remodeling. High levels of active TGFß1 in the bone marrow microenvironment change the fate of mesenchymal stem cells and lead to skeletal disorders such as osteoarthritis. The team is characterizing the markers of mesenchymal stem cells through lineage tracing and determining their role in bone remodeling. In parallel, studies are underway to develop therapies for osteoarthritis by modulating mesenchymal stem cells.

Selected Publications

View all on Pubmed

  1. Bianco P, Cao X, Frenette PS, Mao JJ, Robey PG, Simmons PJ, Wang CY. "The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine." Nat Med. 2013 Jan;19(1):35-42. doi: 10.1038/nm.3028. Epub 2013 Jan 7.
  2. Wan M, Li C, Zhen G, Jiao K, He H, Jia X, Wang W, Shi C, Xing X, Chen Y, Jan De Beur S, Yu B, Cao X. "Injury-activated TGFB controls mobilization of MSCs for tissue remodeling." Stem Cell. 2012;30(11):2498-511. doi: 10.1002.
  3. Xian L, Lou M, Wu X, Yu B, Frassica F, Wan M, Pang L, Wen C, Tryggestad E, Wong J, Cao X. "Pretreatment with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells." Stem Cell Discovery. 2012;2:100-107. doi: 10.4236/scd.2012.23015.
  4. Yu B, Zhao X, Yang C, Xian L, Lu W, Wan M, Cao X. "PTH induces differentiation of mesenchymal stem cells by activation of BMP signaling." JBMR. 2012;27(9):2001-14. doi: 10.1002/jbmr.1663.
  5. Xian L, Wu X, Pang L, Lou M, Rosen C, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Jia X, Yakar S, Xuan S, Efstratiadis A, Wan M, Cao X. "Matrix IGF-1 regulates bone mass by activation of mTOR in mesenchymal stem cells." Nat Med. 2012;18(7):1095-101.
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