Wayne Koch, M.D.

Wayne Koch, M.D.

Professor, Otolaryngology-Head & Neck Surgery and Oncology
Director, Head and Neck Cancer Center

OFFICE PHONE
410-955-4906

EDUCATION - Medical School
University of Pittsburgh

EDUCATION - Residency
Tufts and Boston University

EDUCATION - Fellowship
The Johns Hopkins University - Otolaryngology - Head & Neck Surgery

BOARD CERTIFICATION
American Board of Otolaryngology

CLINICAL INTERESTS

• Head and Neck tumors (larynx, mouth, neck, arterior skull base, throat, lip, tongue, nose sinuses, thyroid, salivary glands)
• Sleep disorders.

RESEARCH INTERESTS

• Genetic changes associated with head and neck cancer
• Use of these as markers for early detection, prognostic factors to select treatment, targets for therapy
• Human papillomavirus as casual factor of head and neck cancer

PRINCIPAL HOSPITAL
Johns Hopkins Hospital

SELECTED PUBLICATIONS

Gourin CG,  Forastiere AA, Sanguineti, Koch WM, Marur S. Bristow RE:  Impact of surgeon and hospital volume on short-term outcome and cost of laryngeal cancer surgical care.  Laryngoscope 2011 Jan; 121(1): 85-90

126.     Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Volume-based trends in laryngeal cancer surgery.  Laryngoscope. 2011 Jan; 121(1): 77-84.

127.     Roh J-L, Kang SK, Califano JA, Sidransky D, Koch, WM. p53-Reactivating Small Molecules Induce Apoptosis and Enhance Chemotherapeutic Cytotoxicity in Head and Neck Squamous Cell Carcinoma.  Oral Oncol   2011 Jan; 47(1): 8-15.

Starmer H, Agrawal N, Koch W, Richmon, J, Webster K, Gourin CG. Does prosthesis diameter matter? The relationship between voice prosthesis diameter and complications.  Otolaryngol Head Neck Surg 2011 May; 144(5): 740-746.

Guerro-Preston R. Soudry E, Acero J, Orera M, Moreno-Lopez L, Macia Colon G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry R, Esteller M, Westra W, Koch W, Califano J, Sidransky D. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Ca Prev Res, Jul;4(7):1061-72. Epub 2011 May 10. 

Gallia GL, Reh DD, Salmasi V, Koch W Isshi M Endonasal Endoscopic Resection of Esthesioneuroblastoma: The Johns Hopkins Hospital Experience and Review of the Literature. Neurosurg Rev 2011, Oct; 34 (4): 465-475, Epub 2011 Jun 8. PMID 21655908

Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Volume-based trends in surgical care of patients with oropharyngeal cancer. Laryngoscope. 2011 Apr; 121(4): 738-745.

Gourin CG, Forastiere AA, Sanguineti G, Marur S, Koch WM, Bristow RE. Impact of surgeon and hospital volume on short-term outcomes and cost of oropharyngeal cancer surgical care. Laryngoscope. 2011 Apr; 121(4) 746-752.

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie T-X, Zhang J, Wang J,  Zhang N, El-Naggar AK, Jasser SA,  Weinstein JN, Treviño L, Drummond JA,  Muzny DM,  Wu Y,  Wood LD, Hruban RH, Westra WH, Koch WM,  Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN.  Exome Sequencing of Head and Neck Squamous Cell Carcinomas Reveals Inactivating Mutations in NOTCH1.  Science,  2011, Aug 26;333(6046):1154-7.

Carvalho AL, Henrique R, Jeronimo C, Nayak CS, Reddy AN, Hoque MO, Chang S, Brait M, Jiang WW, Kim MM, Claybourne Q, Goldenberg D, Khan Z, Khan T, Westra WH, Sidransky D, Koch W, Califano JA.  Detection of promoter hypermethylation in saliva as a biomarker for head and neck squamous cell carcinoma surveillance.  Clin Cancer Res. 2011 Jul 15;17(14):4782-9.  May 31 [Epub ahead of print]

Wu G, Chang X, Yun X, Huang W, Koch WM. Prospective randomized trial of high versus low continuous negative pressure suction in management of chyle fistula after neck dissection for metastatic thyroid carcinoma.   Accepted for Head Neck Sept, 2011 HED-11-0394.

Roh JL, Westra W, Califano J, Sidransky D, Koch W.  Tissue Imprint for Molecular Mapping of Deep Surgical Margins in Patients with Head and Neck Squamous Cell Carcinoma  Accepted Sept 2011  Head Neck  Jan 3. Doi 1002/hed21982  PMID 222223471

Sun W, Zaboli D, Wang H, Liu Y, Arnaoutakis D, Khan T, Khan Z, Koch WM, Califano JA. Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck cancer. class="jrnl"Clin Cancer Res. 2012 Feb 15;18(4):1082-91. Epub 2012 Jan 6.

Loyo M, Schussel J, Colantuoni E, Califano J, Brait M, Kang S, Koch WM, Sidransky D, Westra  WH, Taube JM. Detection of Merkel Cell Virus and correlation with histologic presence of Merkel Cell Carcinoma in sentinel lymph nodes.  class="jrnl"Br J Cancer. 2012 Mar 27;106(7):1314-9.

Chang S, Goldenberg D, Koch WM. The transcervical approach to benign parapharyngeal space tumors.  Accepted to Annals Oto Rhino Laryngol MS 11-5152, March, 2012

Roh JL, Ko JH, Moon SJ, Ryu CH, Choi JY, Koch WM.The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer Lett. 2012 May 22. [Epub ahead of print] PMID: 22634494

Ogawa T, Liggett TE, Melnikov AA, Monitto CL, Kusuke D, Shiga K, Kobayashi T, Horii A, Chatterjee A, Levenson VV, Koch WM, Sidransky D, Chang X. Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance. Cell Cycle. 2012 Apr 15;11(8):1656-63. Epub 2012 Apr 15. PMID: 22487682

Sun W, Zaboli D, Liu Y, Arnaoutakis D, Khan T, Wang H, Koch W, Khan Z, Califano Comparison of promoter hypermethylation pattern in salivary rinses collected with and without an exfoliating brush from patients with HNSCC. JA. PLoS One. 2012;7(3):e33642. Epub 2012 Mar 16.PMID: 22438973