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Daria Gaykalova, Ph.D.

Daria Gaykalova, PhD
Daria Gaykalova, PhD

Instructor, Otolaryngology-Head and Neck Surgery

OFFICE PHONE
410-502-5153

OFFICE FAX
410-614-1411

EDUCATION – Graduate School

University of Medicine and Dentistry of New Jersey | Ph.D. in Cellular and Molecular Pharmacology

EDUCATION – Postdoctoral Fellowship
Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University

RESEARCH INTERESTS

  • Genetic and epigenetic alterations in head and neck cancer
  • Development of head and neck cancer biomarkers
  • Epigenetic mechanisms of transcription regulation
  • Cancer-specific transcription factor signatures

PUBLICATIONS

1. Gaykalova, D.A., Mambo, E., Choudhary, A., Houghton, J., Buddavarapu, K., Sanford, T., Darden, W., Adai, A., Latham, G., Bishop, J., Li, R., Westra, W.H., Hennessey, P., Califano, J.A, and Sun, W. Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One. 2014; 9(3):e93102

2. Sun, W., Gaykalova, D.A., Ochs, M.F., Mambo, E., Arnaoutakis, D., Liu, Y, Loyo, M., Agrawal, N., Howard, J., Li, R., Ahn, S., Fertig, E., Sidransky, D., Houghton, J., Buddavarapu, K., Sanford, T., Choudhary, A., Darden, W., Adai, A., Latham, G., Bishop, J., Sharma, R., Westra, W.H., Hennessey, P., Chung, C.H., and Califano, J.A. NOTCH pathway activation in Head and Neck Cancer. Cancer Res. 2014; 74(4):1091-104

3. Li, R., Ochs, M.F., Ahn, S., Hennessey, P., Tan, M., Soudry, E., Gaykalova, D.A., Uemura, M., Brait, M., Shao, C., Westra, W.H., Bishop, J., Fertig, E., Califano, J.A. Expression microarray analysis reveals alternative splicing of LAMA3 and DST genes in head and neck squamous cell carcinoma. PLoS One. 2014; 9(3):e91263

4. Fertig, E.J., Markovic, A., Danilova, L.V., Gaykalova, D.A., Cope, L., Chung, C.H., Califano, J.A., and Ochs, M.F. Signaling Changes In HNSCC Clinical Subtypes Identified with an Integrated Matrix Factorization Algorithm for DNA Methylation and Gene Expression. PLoS One. 2013; 8(11):e78127

5. Shao, C., Tan, M., Bishop, J.A., Liu, J., Bai, W., Gaykalova, D.A., Ogawa, T., Vikani, A.R., Agrawal, Y., Li, R., Kyoung, K.S., Westra, W.H., Sidransky, D., Califano, J.A. and Ha, P.K. Suprabasin is Hypomethylated and Associated with Metastasis in Salivary Adenoid Cystic Carcinoma. PLoS One. 2012;7(11):e48582

6. Gaykalova, D.A., Vatapalli, R., Glazer, C.A., Bhan, S., Shao, C., Sidransky, D., Ha, P.K. and Califano, J.A. Dose dependent Activation of Putative Tumor Suppressor Gene SBSN by Transcription Factor BORIS. PLoS One, 2012. 7(7):e40389.

7. Gaykalova, D.A., Kulaeva, O.I., Pestov, N.A., Hsieh F.K., and Studitsky, V.M. Experimental Analysis of the Mechanism of Chromatin Remodeling by RNA Polymerase II. Methods Enzymol., 2012. 512: p.293-314.

8. Bhan, S., Negi S.S., Shao C., Glazer C.A., Chuang A., Gaykalova D.A., Sun W., Sidransky D., Ha P.K. and Califano J.A. BORIS Binding to the Promoters of Cancer Testis Antigens, Magea2, Magea3 and Magea4, Is Associated with Their Transcriptional Activation in Lung Cancer. Clin. Can. Res., 2011. 17(13): p.4267-76.

9. Gaykalova, D.A., Vivekananthan, N., Bondarenko, V.A., Bartholomew, B., Clark, D.J., and Studitsky, V.M. A Polar Barrier to Transcription is Circumvented by Remodeller-induced Nucleosome Translocation. Nucleic Acids Res., 2011. 39 (9): p. 3520-3528.

10. Kulaeva, O.I.*, Gaykalova, D.A.*, Pestov, N.A., Golovastov V.V., Vassylyev D.G., Artsimovitch I., and Studitsky V.M. Mechanism of Chromatin Remodeling and Recovery during Passage of RNA Polymerase II. Nat. Struct. Mol. Biol., 2009. 16 (12): p. 1272-1278. * - equal authorship

11. Morozov, A.V., Karissa, F., Gaykalova, D.A., Studitsky, V.M., Widom, J., Siggia. E.D. Using DNA Mechanics to Predict In Vitro Nucleosome Positions and Formation Energies. Nucleic Acids Res., 2009. 37 (14): p. 4707-4722.

12. Gaykalova, D.A., Kulaeva, O.I., Bondarenko, V.A., and Studitsky, V.M. Preparation and Analysis of Uniquely Positioned Mononucleosomes. Chromatin Protocols (Second Edition), Meth. Mol. Biol., 2009. 523: p. 109-123.

13. Kulaeva, O.I., Gaykalova, D.A., and Studitsky, V.M. Transcription through Chromatin by RNA Polymerase II: Histone Displacement and Exchange. Mutat. Res., 2007. 618 (1-2): p. 116-129.

14. Bondarenko, V.A., Steele, L.M., Ujvari, A., Gaykalova, D.A., Kulaeva, O.I., Polikanov, Y.S., Luse, D.S., and Studitsky, V.M. Nucleosomes can Form a Polar Barrier to Transcript Elongation by RNA Polymerase II. Mol. Cell, 2006. 24 (3): p. 469-479.

PATENTS

  • Integrative analysis of epigenetic and transcriptional alterations in head and neck squamous cell carcinomas”
    Invention disclosure C11916. JHU
  • “Methods and Agent for Modulating the RNA Polymerase II-Histone Surface”
    Serial No. 12/952,295. UMDNJ

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