Joseph Califano, M.D.

Joseph Califano, M.D.

Professor, Otolaryngology-Head and Neck Surgery, and Head & Neck Research Division

Dr. Califano's CV

PHONE
Office - 410-955-6420
Clinical - 443-849-8940

EDUCATION - Medical School
Harvard Medical School, Boston , MA

EDUCATION - Residency
The Johns Hopkins University

EDUCATION - Fellowship
Memorial Sloan-Kettering Cancer Center

BOARD CERTIFICATION
American Board of Otolaryngology

CLINICAL INTERESTS

• Transoral robotic surgery
• Endoscopic laser-assisted laryngeal surgery
• Salivary gland tumors
• Tumors of the oral cavity, larynx, pharynx, neck, and skull base
• Thyroid cancer
• Premalignant conditions of the upper aerodigestive tract
• Unknown primary head and neck squamous cell carcinoma
• Skin cancer and melanoma

RESEARCH INTERESTS

• Molecular biologic basis of head and neck cancer and premalignant lesions, genetic alterations in premalignant lesions, and molecular detection and surveillance. Explore more research information at the Division of Head and Neck Cancer.

PRINCIPAL HOSPITAL
Johns Hopkins Hospital AND
Greater Baltimore Medical Center

SELECTED PUBLICATIONS
selected publications from over 170 publications

Carvalho AL, Henrique R, Jeronimo C, Nayak CS, Reddy AN, Hoque MO, Chang S, Brait M, Jiang WW, Kim MM, Claybourne Q, Goldenberg D, Khan Z, Khan T, Westra WH, Sidransky D, Koch W, Califano JA. Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance. Clin Cancer Res. 2011 Jul 12. [Epub ahead of print] PubMed PMID: 21628494.

Pattani KM, Zhang Z, Demokan S, Glazer C, Loyo M, Goodman S, Sidransky D, Bermudez F, Jean-Charles G, McCaffrey T, Padhya T, Phelan J, Spivakovsky S, Bowne HY, Goldberg JD, Rolnitzky L, Robbins M, Kerr AR, Sirois D, Califano JA. Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila Pa). 2010 Sep;3(9):1093-103. Epub 2010 Aug 26. PubMed PMID: 20798208.

Zhou S, Kachhap S, Sun W, Wu G, Chuang A, Poeta L, Grumbine L, Mithani SK, Chatterjee A, Koch W, Westra WH, Maitra A, Glazer C, Carducci M, Sidransky D, McFate T, Verma A, Califano JA. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007; May 1;104(18):7540-5 Epub 2007 Apr 24

Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha PK, Koch WM, Califano JA. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Mar 6

Mithani SK, Smith IM, Topalian SL, Califano JA. Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas.Melanoma Res. 2008 Jun;18(3):214-9.

Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA. TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1alpha Stabilization. Clin Cancer Res. 2010 Feb 1;16(3):857-66. Epub 2010 Jan 26.