Nishant Agrawal, M.D.

Associate Professor, Otolaryngology-Head & Neck Surgery

OFFICE PHONE
410-502-9827

EDUCATION - Medical School
Johns Hopkins University School of Medicine

EDUCATION - Residency
Johns Hopkins Hospital

EDUCATION - Fellowship
Memorial Sloan-Kettering Cancer Center

CLINICAL INTERESTS

• Head and neck surgical oncology including tumors of the oral cavity, pharynx, larynx, neck, salivary glands, thyroid, parathyroid, sinuses, skull base and skin

RESEARCH INTERESTS

• Head and neck cancer genetics and diagnostics.

PRINCIPAL HOSPITAL
The Johns Hopkins Hospital

SELECTED PUBLICATIONS

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN.  Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1.  Science.  2011; 333(6046):  1154-1157.

Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, Yan H, Papadopoulos N, Kinzler KW.  Mutations in CIC and FUBP1 contribute to human oligodendroglioma.  Science.  2011; 333(6048):  1453-1455.

Holdhoff M, Schmidt K, Diehl F, Agrawal N, Angenendt P, Romans K, Edelstein D, Torbenson MS, Kinzler K, Vogelstein B, Choti MA, Diaz LA.  Detection of tumor DNA at the margins of colorectal cancer liver metastasis. Clin Cancer Res.  2011; 17(11):  3551-3557.

Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Hester L, Dore S, Synder SH, Sawa A.  GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron.  2009; 63(1):  81-91.

Diehl F, Schmidt K, Choti M, Romans K, Goodman S, Li M, Thornton K, Agrawal N, Sokoll L, Szabo SA, Kinzler KW, Vogelstein B, Diaz LA.  Circulating tumor DNA to assess tumor dynamics.  Nature Medicine.  2008; 14(9):  985-990.

Farrag TY, Agrawal N, Sheth S, Bettegowda C, Ewertz M, Kim M, Tufano RP.  An algorithm for safe and effective re-operative thyroid bed surgery for recurrent/persistent papillary thyroid carcinoma.  Head and Neck.  2007; 29(12):  1069-1074.

Bettegowda C, Foss CA, Cheong I, Wang Y, Diaz LA, Agrawal N, Fox J, Dick J, Dang LH, Zhou S, Kinzler KW, Vogelstein B, Pomper MG.  Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.  PNAS.  2005;  102:  1145-1150. 

Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A.  S-nitrosylated glyceraldehyde-3-phosphate dehydrogenase initiates apoptotic cell death by nuclear translocation following Siah1 binding.  Nature Cell Biology.  2005;  7:  665-674.

Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A.  p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s disease.  Neuron.  2005;  47:  29-41.

Agrawal N, Bettegowda C, Cheong I, Geschwind J, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, Vogelstein B.  Bacteriolytic therapy can generate a potent immune response against experimental tumors.  PNAS.  2004;  101:  15172-15177.