Current News Releases
Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports, the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys.
Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms.
Better-educated people appear to be significantly more likely to recover from a moderate to severe traumatic brain injury (TBI), suggesting that a brain’s “cognitive reserve” may play a role in helping people get back to their previous lives, new Johns Hopkins research shows.
Damage traced in part to dopamine transport system injury in brain cells
Johns Hopkins scientists report that rats exposed to high-energy particles, simulating conditions astronauts would face on a long-term deep space mission, show lapses in attention and slower reaction times, even when the radiation exposure is in extremely low dose ranges.
Molecular inhibitor represents new treatment target for drugs to halt atherosclerosis
Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.
Three Johns Hopkins University School of Medicine researchers have been awarded two-year grants for their work on potential treatments for diabetes, Novo Nordisk announced this month.
Studies carry implications for understanding cancer
Johns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: When a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.
Findings may advance efforts to better manage the infection
A team of scientists led by Johns Hopkins and Stanford University researchers has laid the groundwork for understanding how variations in immune responses to Lyme disease can contribute to the many different outcomes of this bacterial infection seen in individual patients. A report on the work appears online April 16 in PLOS One.
Johns Hopkins Children’s Center experts urge new parents to pay attention to baby’s poop color
Fecal color and consistency are well-known markers of digestive health in both children and adults, but paying attention to a newborn’s shade of poop can be a decided lifesaver in babies born with the rare, liver-ravaging disorder biliary atresia, commonly heralded by white or clay-colored stool.
Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment.
M. Daniel Lane, a Johns Hopkins biochemist renowned for his groundbreaking studies of the chemical processes within the human body that affect hunger, the feeling of fullness and obesity, as well as for his warmth and brilliance as a scientific mentor to generations of Hopkins researchers—including a future Nobel Prize winner—died at his Baltimore home on April 10 of myeloma. He was 83.
Johns Hopkins-led research into genetic factors that cause kidney disease to progress faster in African-Americans than in whites has been selected as one of the top 10 clinical research achievements of 2013 by the Clinical Research Forum.
In experiments with mice, Johns Hopkins Kimmel Cancer Center scientists have identified an enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies.
Analyzing a national database of hospital inpatient records, a team of researchers reports an expected spike in mortality six days after cardiac surgery, but also a more surprising and potentially troubling jump in deaths at the 30-day mark.
Working with human neurons and fruit flies, researchers at Johns Hopkins have identified and then shut down a biological process that appears to trigger a particular form of Parkinson’s disease present in a large number of patients. A report on the study, in the April 10 issue of the journal Cell, could lead to new treatments for this disorder.
The following announcements are related to awards that have been presented during the American Association for Cancer Research (AACR) Annual Meeting 2014, held in San Diego April 5-9, to researchers at the Johns Hopkins Kimmel Cancer Center.
Ramy El-Diwany is co-founder of the Charm City Clinic in East Baltimore
Ramy El-Diwany, a fifth-year M.D./Ph.D. student at the Johns Hopkins University School of Medicine, has won a 2014 Excellence in Public Health Award from the U.S. Public Health Service (USPHS) Physician Professional Advisory Committee for his contributions to community health services.
Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.
Research linked to stress in mice confirms blood-brain comparison is valid
Johns Hopkins researchers say they have confirmed suspicions that DNA modifications found in the blood of mice exposed to high levels of stress hormone — and showing signs of anxiety — are directly related to changes found in their brain tissues.