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Clinical Trials (Experimental Drug studies)
Neurologic Sequelae of HIV subtype A and D infection and ART (Rakai, Uganda)
This study is the first large population-based study to systematically address questions regarding neurocognitive and associated depressive symptoms and functional status in HIV+ African individuals, compared to HIV-negative persons from the same communities. Such data are urgently needed to: 1) determine the rates of preventable HIV co-morbidities in order to develop appropriate interventions; 2) better plan ART-related health services and social support; 3) and to provide insights into co-morbidities due to HIV effects prior to ART initiation, which could have implications for pre-ART care. The study will also provide important data to examine the role of viral compartmentalization in the underlying pathogenesis of HAND in Africa.
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