The Johns Hopkins University
School of Medicine
Department of Neurology
The Johns Hopkins Hospital
Meyer Bldg, Room 6-109
600 N. Wolfe Street
Baltimore, MD 21287
Dr. Norman Haughey received his PhD in Pharmacology from the University of Manitoba in 1998. He then completed one year of post-doctoral training at the University of Kentucky's Center on Aging before moving to the National Institute on Aging, Gerontology Research Center for an additional two years of fellowship. Dr. Haughey joined the faculty of the Department of Neurology at Johns Hopkins in 2002.
Now an Associate Professor at Hopkins, Dr. Haughey is a member of the JHU NIMH Center with specialization in Neurovirology and Neuroregeneration. His research focuses on signaling pathways that promote the dysfunction and death of neuronal cells. In this context, he is interested in the mechanisms that promote neurotoxic processes in HIV and Alzheimer's related dementias. Dr. Haughey and his colleagues use a multidisciplinary approach including tissue culture, molecular reconfiguration, transgenic or knock-out mice and biochemical approaches in order to identify and modify signal transduction pathways that are associated with neurodegenerative processes. Using these model systems, they have described pathogenic modifications of calcium permeable receptors and transporters that promote excessive calcium accumulation. Current research is focused on mapping perturbations in lipid raft based signal transduction pathways that lead to the oxidative modification of subcellular targets involved in apoptotic and anti-apoptotic signaling.
A second research interest is in the biology of neural stem and neural progenitor cells. In particular, he is interested in the mechanisms that govern the function and survival of neural stem and neural progenitor cells and how these processes are disrupted in neurodegenerative conditions. These interests relate directly to diagnostics, therapeutics, cellular and molecular dynamics.
Peer Review Activities
Dr. Haughey has been active with NIH Study Sections, Grant Review Committees, and has served as an Ad-hoc reviewer for multiple journals including Journal of Neurochemistry, Journal of Neuroimmunology, *Journal of Neuroscience, Journal of Neuroscience Research, Neuroscience, Neurobiology of Aging, Neuromolecular Medicine, Neurobiology of Disease, Biochemical Journal, Canadian Journal of Pharmacology and Physiology, Glia, Cell Death and Differentiation, Journal of Biological Chemistry and the Journal of Neuroimmune Pharmacology.
Principal Investigator on three current awards:
- NIA R01AG023471-0, “HIV Associated CNS Dysfunction with Aging”.
- NINDS R01 MH077542-01, "Dysfunctions of Neural Progenitor in HIV-Dementia."
- NIAA R01 AA017408-01, “Interaction of Alcohol with HIV-Proteins”
Dr. Haughey is co-principal investigator on nine others. Two submitted proposals are pending.