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Keratoconus Research at the Johns Hopkins Wilmer Eye Institute



Keratoconus is a disease characterized by abnormal thinning and steepening of the cornea, the clear front surface of the eye, resulting in loss of vision. This disorder generally begins in the second decade of life and affects both eyes in most patients. Keratoconus is relatively common, estimated to occur in approximately one in 2,000 individuals. 

The causes of keratoconus​ and underlying pathogenic changes are poorly understood.The keratoconus research team, comprised of some of the most accomplished experts in research and clinical care, are trying to change that. Basic science discoveries are being translated into increased understanding of the origins and progression of the disease, and exploration of new treatments and therapies.


Current Research
Learn more about keratoconus research and studies being conducted by our team. 

Dr. Akpek

Our Team
Meet the experts who are researching the diagnosis, management and treatment of keratoconus.

Dr. Soiberman and CXL treatment

Treatments for Keratoconus
Explore the various treatments that are currently available for keratoconus.

Areas of Focus

Specifically, our researchers are focused on:

  • Establishing a database of keratoconus patients at the Wilmer Eye Institute with clinical information including disease severity, associated medical problems, and family history
  • Identifying novel therapies for keratoconus through the study of biological pathways that govern the outermost layer of the cornea (epithelium)
  • Investigating the importance of mild, chronic inflammation as a cause of keratoconus
  • Identifying genes and testing DNA associated with keratoconus using new methods of genetic analysis
  • Developing and testing new treatments for keratoconus
  • Developing cell culture models of keratoconus to specifically study candidate gene functions