Web notes  

November 2019

Radiology Archives

1. Brasic JR, Mathur AK, Budimirovic DB. The urgent need for molecular imaging to con?rm target engagement for clinical trials of fragile X syndrome and other subtypes of autism spectrum disorder. Arch Neurosci. 2019; 6(Brain mapping):e91831. DOI: 10.5812/ans.91831
Key words: Neurotransmission, Positron Emission Tomography, Receptors, Single-Photon
Emission Computed Tomography, Transporters
no PMID available

2. Lin Z, Sur S, Soldan A, Pettigrew C, Miller M, Oishi K, Bilgel M, Moghekar A, Pillai JJ, Albert M, Lu H. Brain oxygen extraction by using MRI in older individuals: relationship to apolipoprotein E genotype and amyloid burden. Radiology. 2019 Jul;292(1):140-148.
Key words: Apolipoprotein-E4, Oxygen Extraction Fraction, Alzheimer's disease, T2-Relaxation-Under-Spin-Tagging, Amyloid burden

3. Smith GS, Mills KA, Pontone GM, Anderson WS, Perepezko KM, Brasic J, Zhou Y, Brandt J, Butson CR, Holt DP, Mathews WB, Dannals RF, Wong DF, Mari Z. Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism in Parkinson's disease. Parkinsonism Relat Disord. 2019 July; 64:235-241.
Key words: Positron emission tomography (PET), Parkinson's disease, VMAT2, Dopamine, Glucose metabolism, Deep brain stimulation, Sub-thalamic nucleus
PMID: 31053531

1. Buda M, Wildman-Tobriner B, Hoang JK, Thayer D, Tessler FN, Middleton WD, Mazurowski MA. Management of thyroid nodules seen on US Images: deep learning may match performance of radiologists. Radiology. 2019 Jul 9:181343. doi: 10.1148/radiol.2019181343.
Key words: thyroid ultrasound, thyroid cancer, thyroid nodules


2. Wildman-Tobriner B, Buda M, Hoang JK, Middleton WD, Thayer D, Short RG, Tessler FN, Mazurowski MA. Using artificial intelligence to revise ACR TI-RADS risk stratification of thyroid nodules: diagnostic accuracy and utility. Radiology. 2019 Jul;292(1):112-119. doi: 10.1148/radiol.2019182128.
Key words: thyroid ultrasound, thyroid cancer, thyroid nodules


1. Brasic, JR. The urgent need for protective shielding for personnel who administer radiopharmaceuticals. Radiology and Medical Diagnostic Imaging. 2019;2(3):2-3. doi: 10.31487/j.RDI.2019.03.06
Key words: Computed tomography (CT); Estimation; Mathematical modeling; Nuclear medicine; Occupational safety; Positron emission tomography (PET); Radiation exposure https://www.sciencerepository.org/articles/the-urgent-need-for-protective-shielding-for-personnel-who-administer-radiopharmaceuticals_RDI-2019-3-106.pdf
No PMID available

1. Bhatt G, Jain A, Bhatt A, Civelek AC. Intramedullary spinal cord metastases and 18F-FDG PET-CT: case report. Quant Imaging Med Surg. 2019 Mar;9(3):530-534. doi: 10.21037/qims.2019.03.05
Key words: Spinal cord metastases, FDG PET-CT

2. Parekh VS, Jacobs MA. Deep learning and radiomics in precision medicine. Expert Rev Precis Med Drug Dev. 2019;4(2):59-72. doi: 10.1080/23808993.2019.1585805. Epub 2019 Apr 19.
Key words: Deep Learning, Radiomics, Precision medicine

3. Smith GS, Mills KA, Pontone GM, Anderson WS, Perepezko KM, Brasic J, Kuwabara H, Zhou Y, Brandt J, Butson CR, Holt DP, Mathews WB, Dannals RF, Wong DF, Mari Z. Effect of STN DBS on vesicular monoamine transporter 2 and glucose metabolism in Parkinson's disease. Parkinsonism Relat Disord. 2019 Apr 16.
Key words: positron emission tomography (PET), Parkinson's Disease, VMAT2, dopamine, glucose metabolism, deep brain stimulation, sub-thalamic nucleus
PMID: 31053531

1. Agarwal S, Sair HI, Gujar S, Hua J, Lu H, Pillai JJ. Functional magnetic resonance imaging activation optimization in the setting of brain tumor-induced neurovascular uncoupling using resting-state blood oxygen level-dependent amplitude of low frequency fluctuations. Brain Connectivity. 2019 April; 9(3):241-250.
Key words: frequency domain metrics ALFF (amplitude of low frequency fluctuations); motor activation; neurovascular uncoupling; presurgical mapping

2. Obusez EC, Jones SE, Mandell D, Bullen J, Gonzalez F, Hui FK. Feasibility of vessel wall imaging in assessing unruptured paraclinoid aneurysms: Clinical observations and preliminary experience. J Clin Neurosci. 2019 Mar;61:59-65. doi: 10.1016/j.jocn.2018.10.145.
Key words: cavernous sinus aneurysms; paraclinoid aneurysms; subarachnoid hemorrhage; Vessel wall magnetic resonance imaging

1. Banerjee S, Kaitlin A. Quinn KA, Gribbons KB, Joel S. Rosenblum JS, Civelek AC, Novakovich E, Merkel PA, Mark A. Ahlman MA, Peter C. Grayson PC. Effect of treatment on imaging, clinical, and serologic assessments of disease activity in large-vessel vasculitis. J Rheumatol. 2019 Mar 15. pii: jrheum.181222.
Key words: vasculitis, large-vessel vasculitis, giant cell arteritis, Takayasu's arteritis, positron emission tomography, fluorodeoxyglucose

2. Jha A, de Luna K, Balili CA, Millo, Paraiso CA, Ling A, Gonzales MK, Viana B, Alrezk R, Adams KT, Tena I, Chen A, Neuzil J, Raygada M, Kebebew E, Taïeb D, O'Dorisio S, O'Dorisio T, Civelek AC, Stratakis CA, Mercado-Asis L, and Pacak K. Clinical, diagnostic, and treatment characteristics of SDHA-related metastatic pheochromocytoma and paraganglioma. Front. Oncol. 2019 Feb 22; 9:53.
Key words: 123I-MIBG; 18F-FDG; 18F-FDOPA; 68Ga-DOTATATE; PET/CT; SDHA; paraganglioma; pheochromocytoma

3. Park JS, Oh Y, Park YJ, Park O, Yang H, Slania S, Hummers LK, Shah AA, An HT, Jang J. Horton MR, Shin J, Dietz HC, Song E, Na DH, Park EJ, Kim K, Lee KC, Roschke VV, Hanes J, Pomper MG, Lee S, Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma. Nat Commun. 2019 Mar; 10(1):1128.
Key words: fibrosis, myofibroblast, scleroderma, TRAIL

1. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Shah SP, Wharram B, Lesniak GW, Tully E, Gabrielson E, Jaffe ME, Poirier TJ, Rudin MC, Gobburu VSJ, Pomper GM, Nimmagadda S. Peptide-based PET quantifies target engagement of PD-L1 therapeutics. J Clin Invest. 2019;129:616-630.
Key words: PET, Immunotherapy, Immune checkpoint, PD-L1, Peptide

1. Elkashef A, Braši? JR, Cantelina Jr LR, Kahn R, Chiang N, Ye W, Zhou Y, Mojsiak J, Warren KR, Crabb A, Hilton J, Wong DF, Vocci F. A cholecystokinin B receptor antagonist and cocaine interaction, phase I study. CNS Neurosci Ther. 2019 Jan; 25(1): 136-46.
Key words: addiction, craving, dopamine, pharmacokinetics, positron emission tomography (PET)

2. Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG. PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A. 2019 Jan 11. pii: 201812155. doi: 10.1073/pnas.1812155116. [Epub ahead of print]
Key words: neuroinflammation, positron emission tomography, tyrosine-protein kinase, [11C]CPPC, DAM

3. McKay GN, Harrigan TP, Brasic JR. A low-cost quantitative continuous measurement of movements in the extremities of people with Parkinson's disease. MethodsX. 2019; 6:169-189.
Key words: accelerometry, data logger, instrumentation, signal processing, tremor
No PMID available

4. Senarathna J, Yu H, Deng C, Zou AL, Issa JB, Hadjiabadi DH, Gil S, Wang Q, Tyler BM, Thakor NV, Pathak AP, A miniature multi-contrast microscope for functional imaging in freely behaving animals. Nature Communications. 2019 Jan 9;10(1):99. doi: 10.1038/s41467-018-07926-z.
Key words: functional imaging, awake animals, neurovascular, angiogenesis, brain tumors, freely behaving

1. Lesniak WG, Chu C, Jablonska A, Du Y, Pomper MG, Walczak P, Janowski M. PET imaging of intra-arterial 89Zr bevacizumab in mice with and without osmotic opening of the blood-brain barrier: distinct advantage of intra-arterial delivery. J Nucl Med. 2018 Oct 12. pii: jnumed.118.218792. doi: 10.2967/jnumed.118.218792. [Epub ahead of print]
Key words: brain, drug delivery, PET imaging

1. Mahesh M. Essential role of a medical physicist in the Radiology department. Radiographics. 2018 Oct;38(6):1665-1671. doi: 10.1148/rg.2018180111.
Key words: Medical Physics, Radiology Department, Quality & Safety, Medical Physicist's Role

2. Morin R, Mahesh M. Role of noise in medical imaging. J Am Coll Radiol. 2018 Sep;15(9):1309. doi: 10.1016/j.jacr.2018.07.003. No abstract available.
Key words: Imaging, Image Noise

3. Sujlana PS, Mahesh M, Vedantham S, Harvey SC, Mullen LA, Woods RW. Digital breast tomosynthesis: Image acquisition principles and artifacts. Clin Imaging. 2018 Sep 13. pii: S0899-7071(18)30201-8. doi: 10.1016/j.clinimag.2018.07.013. [Epub ahead of print] Review.
Key words: Artifacts, Digital Tomosynthesis

1. Solnes L, Gomez E, Magid D, Johnson P. 6 Steps to Radiology: Part 3 -- Nailing the residency interview. AuntMinnie.com: 10 Oct. 18.
Key words: residency, match, advising, interview, medical student

1. Barker PB, Lin DDM, Mahesh M. Retention concerns about MR studies using gadolinium-based contrast agents. J Am Coll Radiol. 2018 Jun;15(6):934-936. doi: 10.1016/j.jacr.2018.02.014.
Key words: Gadolinium(Gd) contrast, MRI, Retention of Gd contrast

2. Brasic JR, Mari Z, Lerner A, Raymont V, Zaidi E, Wong DF. Remission of Gilles de la Tourette syndrome after heat-induced dehydration. Int J Phys Med Rehabil. 2018 June 13;6(3). DOI: 10.4172/2329-9096.1000472
Key words: Basal ganglia; Dopamine; Hypothalamus; Substantia nigra; Thermoregulation
No PMID available

3. Elkashef A, Brasic JR, Cantelina Jr LR, Kahn R, Chiang N, Ye WG, Zhou Y, Mojsiak J, Warren KR, Crabb A, Hilton J, Wong DF, Vocci F. A cholecystokinin B receptor antagonist and cocaine interaction, phase I study. CNS Neurosci Ther. 2018 Jun 20. doi: 10.1111/cns.12994. [Epub ahead of print]
Key words: Clinical trial; dopamine receptor; positron emission tomography; relapse prevention; substance dependence
PMID: 29923314

4. Khan M, Ambady P, Kimbrough D, Shoemaker T, Terezakis S, Blakeley J, Newsome SD, Izbudak I. Radiation-induced myelitis: initial and follow-up MRI and clinical features in patients at a single tertiary care institution during 20 years. American Journal of Neuroradiology. 2018 May 17. doi: 10.3174/ajnr.A5671. [Epub ahead of print]
Key words: Magnetic resonance imaging; Myelitis; Radiation therapy; Radiosensitization
PMID: 29773568

5. Khan M, Deib G, Deldar B, Patel A, Barr J. Efficacy and safety of percutaneous microwave ablation and cementoplasty in the treatment of painful spinal metastases and myeloma. American Journal of Neuroradiology. 2018 Jul;39(7):1376-1383.
Key words: Spine metastases; Ablation; Visual Analogue score; Disability index; Radiation therapy
PMID: 29794238

6. Morin R, Mahesh M. Contrast resolution role in medical imaging. J Am Coll Radiol. 2018 Jun 7. pii: S1546-1440(18)30535-0. doi: 10.1016/j.jacr.2018.05.002. [Epub ahead of print]
Key words: Image Contrast, Medical Imaging, Radiation Dose

7. Morin RL, Mahesh M. The importance of spatial resolution to medical imaging. J Am Coll Radiol. 2018 May 7. pii: S1546-1440(18)30384-3. doi: 10.1016/j.jacr.2018.03.042. [Epub ahead of print]
Key words: Spatial Resolution, CT, imaging, Image quality

1. Oishi K, Chang L, Huang H. Baby brain atlases. Neuroimage. 2018 Apr 3;. [Epub ahead of print]
Key words: Brain atlas; Early development; Infant; Neonate; Prenatal exposure; Preterm birth

2. Patel S, Oishi K, Wright A, Sutherland-Foggio H, Saxena S, Sheppard SM, Hillis AE. Right hemisphere regions critical for expression of emotion through prosody. Front Neurol. 2018 Apr 6;9:224.
Key words: communication; emotion; prosody expression; right hemisphere; stroke

3. Taguchi K, Itoh T, Fuld MK, Fournie E, Lee O, Noguchi K. "X-Map 2.0" for edema signal enhancement for acute ischemic stroke using non-contrast-enhanced dual-energy computed tomography. Investigative Radiology. 2018 Jul;53(7):432-439.
Key words: acute ischemic stroke, dual-energy, non-contrast-enhanced CT

4. Wong DF, Blue ME, Braši? JR, Nandi A, Valentine H, Stans?eld KH, Rousset O, Bibat G, Yablonski ME, Johnston MV, Gjedde A, Naidu SB. Are dopamine receptor and transporter changes in Rett syndrome re?ected in Mecp2-de?cient mice? Experimental Neurology. 2018 May 18; 307: 74-81.
Key words: autopsy; autoradiography; developmental disabilities; partial volume correction; Positron Emission Tomography
PMID: 29782864

1. Alizadeh M, Intintolo A, Middleton DM, Conklin CJ, Faro SH, Mulcahey MJ, Mohamed FB. Reduced field of view diffusion tensor imaging and fiber tractography of the pediatric cervical and thoracic spinal cord injury. Journal of Neurotrauma Feb. 1 2018 35:452-460 doi/10.1089/neu.2017.5174
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 27527237

2. Alizadeh M, Intintolo A, Middleton DM, Conklin CJ, Saksena S, Faro SH, Flanders A, Krisa L, Mulcahey MJ, Mohamed FB. Application of color transformation techniques in pediatric spinal cord MR images: typically developing and spinal cord injury population. J Digit Imaging. 2018 Jan 16. doi: 10.1007/s10278-017-0048-5. [Epub ahead of print]
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 29340396

3. Alizadeh M, Shah P, Middleton D, Conklin C, Saksena S, Faro SH, Mulcahey MJ, Finsterbusch J, Mohamed FB. Identification of ghost artifact using texture analysis in pediatric spinal cord diffusion tensor images. Magnetic Resonance Imaging. 2018 Apr;47:7-15.
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 29154897

4. Fatemi SH, Wong DF, Braši? JR, Kuwabara H, Mathur A, Folsom TD, Jacob S,. Realmuto GM, Pardo JV, Lee S. Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study. Cerebellum Ataxias. 2018;5:3.
Key words: cerebellum, postcentral gyrus, precuneus, [18F]-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile, rating scale
PMID: 29449954

5. O+sefsson A, Hobbs RF, Ranka S, Schwarz B, Plyku D, Willegaignon de Amorien de Carvalho J, Buchpiguel C, Sapienza M, Bolch W, Sgouros, G. Comparative Dosimetry for 68Ga-DOTATATE: Impact of using Updated ICRP phantoms, S values and Tissue Weighting Factors. J Nucl Med Feb 9, 2018; jnumed.117.203893.
Key words: PET/CT; Radiobiology/Dosimetry; Radiopharmaceuticals; Gallium-68-DOTATATE; PET/CT-imaging; dosimetry; effective dose; normal tissue
PMID: 29439017

6. Lai S, Heaphy CM, Rizzo AJ, Celentano DD, Gerstenblith G, Li J, Moore RD, Treisman G, Chen S, Foster P, Kickler T, Lai H. Cocaine use may induce telomere shortening in individuals with HIV infection. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;84(Pt A):11-17. doi: 10.1016/j.pnpbp.2018.01.015. [Epub ahead of print]
Key words: Cocaine use; HIV infection; HIV-associated comorbidities; Premature aging; Telomere length; Telomere shortening
PMID: 29410247

7. McDevitt MR, Sgouros G, Sofou S. Targeted and nontargeted ?-particle therapies. Annu Rev Biomed Eng. 2018 Jan 18. doi: 10.1146/annurev-bioeng-062117-120931. [Epub ahead of print]
Key words: ?-particle, actinium-225, radium-223, targeted therapy, radioimmunotherapy, nanoparticles
PMID: 29345977

1. Hwang BJ, Mohamed MA, Braši? JR. Molecular imaging of autism spectrum disorder. Int Rev Psychiatry. 2017 Dec;29(6):530-54.
Key words: dopamine; magnetic resonance spectroscopy; positron emission tomography; single photon emitted computed tomography; serotonin
PMID: 29231773

1. Gang GJ, Zbijewski W, Mahesh M, Thawait G, Packard N, Yorkston J, Demehri S,Siewerdsen JH. Image quality and dose for a multi-source cone-beam CT extremity scanner. Med Phys. 2017 Nov 9. doi: 10.1002/mp.12659. [Epub ahead of print]
Key words: Cone-beam CT, Extremity Scanner, Radiation Dose, Image Quality

2. Morin RL, Mahesh M. Radiation exposure and patient dose in cardiology. J Am Coll Radiol. 2017 Oct 20. pii: S1546-1440(17)31110-9. doi: 10.1016/j.jacr.2017.09.003. [Epub ahead of print] No abstract available.
Key words: Radiation dose, Catheterization procedures, flat panel detectors, Patient dose

1. Mahesh M. New conversion factors for estimating effective doses during cardiac CTA. JACC Cardiovasc Imaging. 2017 Aug 12. pii: S1936-878X(17)30699-X. doi: 10.1016/j.jcmg.2017.07.007. [Epub ahead of print] No abstract available.
Key words: Effective Dose, Conversion Factors, Cardiac CT

2. Marsh RM, Balter S, Mahesh M. Personal protective equipment in interventional fluoroscopy: distinguishing evidence from hype. J Am Coll Radiol. 2017 Sep 22. pii: S1546-1440(17)31009-8. doi: 10.1016/j.jacr.2017.08.017. [Epub ahead of print] No abstract available.
Key words: Fluoroscopy, Protective Equipment, Radiation Safety

3. Martin CJ, Vassileva J, Vano E, Mahesh M, Ebdon-Jackson S, Ng K, Frush DP, Loose R, Damilakis J. Unintended and accidental medical radiation exposures in radiology: guidelines on investigation and prevention. J Radiol Prot. 2017 Aug 24. doi: 10.1088/1361-6498/aa881e. [Epub ahead of print]
Key words: Radiation, Accidental Exposures, Prevention, Guidelines

4. Pacher P, Steffens S, Hasko G, Schindler TH, Kunos G. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad and the ugly. Nat Rev Cardiol. 2017 Sep 14. doi: 10.1038/nrcardio.2017.130. [Epub ahead of print] Review. (IF: 14.299)
Key words: endocannabinoids, cardiovascular, marijuana, cannabinoid receptors, central nervous system, obesity

1. Brasic JR. A 20-year-old man who stopped speaking. Medscape. Updated July 31, 2017.
Key words: autism spectrum disorders, movement disorder, catatonia, dopamine receptor blocking drugs, electroconvulsive treatments
No PMID available

2. Chareonthaitawee P, Beanlands RS, Chen W, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, DiCarli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI-ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring. Expert Consensus Document of the Cardiovascular Council of the Society of Nuclear Medicine and Molecular Imaging and the American Society of Nuclear Cardiology . J Nucl Cardiol. 2017 Aug 2. doi: 10.1007/s12350-017-0978-9. [Epub ahead of print]
Key words: FDG-PET, cardiac sarcoidosis, immunosuppression, position-paper

3. Chareonthaitawee P, Beanlands RS, Chen W, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, DiCarli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. The Role of PET/CT in Cardiac Sarcoid Detection and Monitoring Therapy. Expert Consensus Document of the Cardiovascular Council of the Society of Nuclear Medicine and Molecular Imaging and the American Society of Nuclear Cardiology. J Nucl Med. 2017 Aug;58(8):1341-1353. doi: 10.2967/jnumed.117.196287. (IF:6.6)
Key words: FDG-PET, cardiac sarcoidosis, immunosuppression, position-paper

4. Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. Science. Aug 4;357(6350):503-507.
Key words: hM4Di, hM3Dq, neuromodulation, chemogenetics, designer receptors, designer drugs

5. Lesniak WG, Aboye T, Camarero JA, Chatterjee S, Camarero JA, Nimmagadda S. In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent. Chemistry. 2017 Aug 3. doi: 10.1002/chem.201702540. [Epub ahead of print]
Key words: CXCR4, cyclotide, molecular imaging, PET
PMID: 28771849

6. Leucker T, Valenta I, Schindler TH. PET-determined hyperemic flow, myocardial flow reserve and flow gradient - quo vadis? Front Cardiovasc Med 2017 Jul 17;4:46. doi: 10.3389/fcvm.2017.00046. eCollection 2017. Review.
Key words: CAD, FFR, myocardial blood flow, myocardial flow reserve, longitudinal flow gradient, PET

7. Nedrow JR, Josefsson A, Park S, Bäck T, Hobbs RF, Brayton C, Bruchertseifer F, Morgenstern A, Sgouros G. Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. EJNMMI Res. 2017 Dec;7(1):57. doi: 10.1186/s13550-017-0303-2. Epub 2017 Jul 18.
Key words: Alpha-particle emitting radioimmunotherapy; Anti-PD-L1 antibodies; Dosimetry; Immune checkpoint inhibition; Pharmacokinetics

8. Nedrow JR, Josefsson A, Park S, Ranka S, Roy S, Sgouros G. Imaging of programmed death ligand-1 (PD-L1): impact of protein concentration on distribution of anti-PD-L1 SPECT agent in an immunocompetent melanoma murine model. J Nucl Med. 2017 May 18. pii: jnumed.117.193268. doi: 10.2967/jnumed.117.193268. [Epub ahead of print]
Key words: Animal Imaging; Molecular Imaging; SPECT; anti-PD-L1; immune checkpoint inhibitors; melanoma; targeted antibodies

1. Anderson BA, Kuwabara H, Wong DF, Roberts J, Rahmim A, Braši? JR, Courtney SM. Linking dopaminergic reward signals to the development of attentional bias: a positron emission tomographic study. NeuroImage. 2017 May 30;157:27-33. doi: 10.1016/j.neuroimage.2017.05.062.
Key words: Caudate nucleus; cerebral hemisphere; color-defined targets; dorsal striatum; neural mechanisms
PMID: 28572059

2. Schindler TH. Emergence of integrated cardiac magnetic resonance/positron emission tomography imaging as the preferred imaging modality in cardiac sarcoidosis. JACC Cardiovasc Imaging. 2017 Jun 9. pii: S1936-878X(17)30451-5. doi: 10.1016/j.jcmg.2017.02.022. [Epub ahead of print]
Key words: cardiac sarcoidosis, infiltrative disease, inflammation, perfusion, PET, CMR, MR-PET

1. Bennink LL, Smith DJ, Foss CA, Pomper MG, Li Y, Yu SM. High Serum Stability of Collagen Hybridizing Peptides and Their Fluorophore Conjugates. Mol Pharm. 2017 Jun 5;14(6):1906-1915. doi: 10.1021/acs.molpharmaceut.7b00009. Epub 2017 May 8.
Key words: collagen mimetic peptide; extracellular matrix; peptide degradation; proline peptidase pharmacokinetics; theranostics

2. Foss CA, Liu L, Mease RC, Wang H, Pasricha P, Pomper MG. Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with [125I]iodoDPA SPECT-CT. Mol Pharm. 2017 Jun 5;14(6):1906-1915. doi: 10.1021/acs.molpharmaceut.7b00009. Epub 2017 May 8.
Key words: FDG; Gastrointestinal; Molecular Imaging; SPECT/CT; TSPO; chronic pancreatitis; macrophages

3. Lai S, Gerstenblith G, Moore RD, Celentano DD, Bluemke DA, Treisman G, Liu CY, Li J, Chen S, Kickler T, Lai H. Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis. Drug Alcohol Depend. 2017 May 26;177:84-92. doi: 10.1016/j.drugalcdep.2017.03.029. [Epub ahead of print]
Key words: African Americans; Antiretroviral therapy; Cocaine use; HIV infection; Hepatic triglyceride content; Myocardial triglyceride content

4. Schindler TH. Another potential step to improve prosthetic heart valve endocarditis imaging with 18F-FDG PET/CT. Nucl Cardiol. 2017 Jun 5. doi: 10.1007/s12350-017-0935-7. [Epub ahead of print]
Key words: cardiac diseases, device infection, endocarditis, prosthetic valve, PET,.

1. Bar-Shir A, Alon L, Korrer MJ, Lim HS, Yadav NN, Kato Y, Pathak AP, Bulte JWM,
Gilad AA. Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy. Magn Reson Med. 2017 May 7. doi: 10.1002/mrm.26708. [Epub ahead of print]
Key words: MRI; Reporter gene; dendritic cells (DCs); drosophila melanogaster 2?-deoxynucleoside kinase (Dm-dNK); fluorescence-activated cell sorting (FACS); pyrrolo-2?-deoxycytidine (pyrrolo-dC)
PMID: 28480589

2. Brasic JR. Autism. Medscape Drugs & Diseases. Updated April 21, 2017.
Key words: checklist, communication, rating scales, screening, social interactions
No PMID available

3. Brasic JR. Tardive Dyskinesia. Medscape Reference. Updated April 24, 2017.
Key words: checklist, neuroleptics, rating scales, screening, movement disorders
No PMID available

4. Ganapathy-Kanniappan S. Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities. Biochim Biophys Acta. 2017 Apr 8; 1868(1):212-220.
Key words: cancer metabolism, immune evasion, immunotherapy


5. Ganapathy-Kanniappan S. Taming tumor glycolysis and potential implications for immunotherapy. Front Oncol. 2017 Mar 13;7:36.
Key words: Tumor glycolysis, tumor microenvironment, cancer immunotherapy, NK cell therapy

6. Mahesh M, Madsen M. Addressing technetium-99m shortage. J Am Coll Radiol. 2017 May;14(5):681-683. Epub 2017 Apr 2. No abstract available.
Key words: Technetium-99m, Nuclear Medicine Procedures, Supply-Demand of Tc-99m, Production of Tc-99m

7. Mahesh M, Morin RL. Physician leadership in radiation dose optimization. J Am Coll Radiol. 2017 May 2. pii: S1546-1440(17)30300-9.
Key words: Radiation Dose, Leadership Role, Dose Optimization

8. Rubin GD, Krishnaraj A, Mahesh M, Rajendran RR, Fishman EK. Enhancing public access to relevant and valued medical information: fresh directions for radiologyInfo.org. J Am Coll Radiol. 2017 May;14(5):697-702.e4. Epub 2017 Jan 28.
Key words: Radiologyinfo.org, Public access, Radiology Information, Radiation Dose, Patient Safety

1. Gregg L, Eckart Sorte D, Gailloud P. Intraforaminal location of thoracolumbar radicular arteries providing an anterior radiculomedullary artery using flat-panel catheter angiotomography. Am J Neuroradiol. 2017 Feb 16. doi: 10.3174/ajnr.A5104. [Epub ahead of print]
Key words: radicular artery, flat-panel catheter angiotomography, transforaminal epidural steroid injection

1. Jha AK, Frey E. No-gold-standard evaluation of image-acquisition methods using patient data. Proc. SPIE 10136, Medical Imaging 2017. March 2017; 101360L
Key words: Image quality, quantitative imaging
No PMID available

2. Jha AK, Mena E, Caffo B, Ashrafinia S, Rahmim A, Frey EC, Subramaniam R. Practical no-gold-standard framework to evaluate quantitative imaging methods: Application to lesion segmentation in PET. J. Med. Imag.(Special Section on PET imaging) 2017 Jan; 4(1); 011011.
Key words: PET imaging, tumor segmentation, cancer
PMID: 28331883

3. Jha AK, Zhu Y, Wong DF, Rahmim A. A radiative transfer equation-based image-reconstruction method incorporating boundary conditions for diffuse optical imaging. Proc. SPIE 10137, Medical Imaging 2017: 1013705; March 13, 2017.
Key words: Optical imaging, Photon transport
No PMID Available

4. Mena E, Sheikhbahaei S, Taghipour M, Jha AK, Xiao J, Vicente E, Subramaniam RM, 18F-FDG PET/CT Metabolic tumor volume and intra-tumoral heterogeneity: impact of dual-time-point and segmentation methods. Clin. Nuc. Med. Jan. 2017; 42(1)
Key words: Tumor heterogeneity, FDG-PET imaging, tumor segmentation, cancer

5. Mena E, Taghipour M, Sheikhbahaei S, Jha AK, Solnes L, Subramaniam RM, Value of intra-tumoral metabolic heterogeneity and quantitative 18F-FDG PET/CT parameters to predict prognosis, in patients with HPV-positive primary oropharyngeal squamous cell carcinoma. Clin. Nuc. Med. 2017 Feb 13.
Key words: Tumor heterogeneity, FDG-PET imaging, cancer

6. Zhu Y, Jha AK, Dreyer JK, Le H, Kang JU, Roland PE, Wong DF, Rahmim A. A three-step reconstruction method for fluorescence molecular tomography based on compressive sensing. Proc. SPIE 10059 17 Feb 2017; 1005911
Key words: Optical imaging, Transcranial imaging

1. Kruse MJ, Kovell L, Kasper EK, Pomper MG, Moller DR, Solnes L, Chen ES, Schindler TH. Myocardial blood flow and inflammatory cardiac sarcoidosis. JACC Cardiovasc Imaging. 2017 Feb;10(2):157-167. doi: 10.1016/j.jcmg.2016.09.023.
Key words: fibrosis, inflammation, myocardial blood flow, necrosis, PET, sarcoidosis

2. Schindler TH. Cardiovascular PET/MR:"Not the end but the beginning." J Nucl Cardiol. 2017 Jan 26. doi: 10.1007/s12350-017-0784-4. [Epub ahead of print].
Key words: cardiac diseases, infiltrative disease ,MRI, PET, sarcoidosis, viability

3. Sebastian R, Saxena S, Tsapkini K, Faria AV, Long C, Wright A, Davis C, Tippett DC, Mourdoukoutas AP, Bikson M, Celnik P, Hillis AE. Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke. Front Hum Neurosci. 2017 Jan 12;10:695.
Key words: aphasia, cerebellar tDCS, resting state fMRI, spelling therapy, stroke

1. Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. 2016 Dec 24; pii: S0006-291X(16)32216-1.
Key words: Immunotherapy; Immune checkpoint; Diagnostics; Peptides; PD-1.

2. Mahesh M, Barker PB. The MRI helium crisis: past and future. J Am Coll Radiol. 2016 Dec;13(12 Pt A):1536-1537. doi: 10.1016/j.jacr.2016.07.038. No abstract available.
Key words: Magnetic Resonance Imaging, Helium, MR Technology, MR scanners, Helium Reserves

3. Quercioli A, Carbone F, Bonaventura A, Liberale L, Pataky Z, Thomas A, Lenglet S, Lauer E, Golay A, Dallegri F, Di Marzo V, Schindler TH, Montecucco F. Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function. Int J Cardiol. 2016 Dec 13. pii: S0167-5273(16)32953-9. doi: 10.1016/j.ijcard.2016.12.023. [Epub ahead of print]
Key words: CAD, coronary circulation, endocannabinoids, myocardial blood flow, obesity, PET, vasomotor function

1. Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X, Peters ME, Dougherty JW, Vranesic M, Koo SM, Ahn H-H, Lee M, Cottrell C, Sair HI, Sawa A, Munro CA, Nowinski CJ, Dannals RF, Lyketsos CG, Kassiou M, Smith G, Caffo B, Mori S, Guilarte TR, Pomper MG. Imaging of glial cell activation and white matter integrity in the brains of active and recently retired National Football League players. JAMA Neurol. 2017 Jan 1;74(1):67-74.
Key words: NFL, TBI, TSPO, Neuro PET, DTI

2. Hapuarachchige S, Artemov D. Click chemistry in the development of contrast agents for magnetic resonance imaging. Top Magn Reson Imaging. 2016 October;25(5):205-213.
Key words: Magnetic resonance imaging; targeted imaging agents; click chemistry

3. Mahesh M, Morin RL. Radiation changes in the 21st century. J Am Coll Radiol. 2016 Nov;13(11):1404. doi: 10.1016/j.jacr.2016.07.002. No abstract available.
Key words: Computed Tomography, Radiation Dose, Medical Imaging

4. Yang H, Schaffer K, Liu L, Mahesh M, Yousem DM. Benchmarking lumbar puncture fluoroscopy time during fellowship training. AJNR Am J Neuroradiol. 2016 Dec 1. [Epub ahead of print]
Key words: Fluoroscopy, Radiation Exposure, Training

1. Liu P, Welch BG, Li Y, Gu H, King D, Yang Y, Pinho M, Lu, H. Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI. NeuroImage: 2016 Sep 28. Pii: S1053-8119(16)30541-9. doi: 10.1016/j.neuroimage.2016.09.063.
Key words: Cerebrovascular reactivity, Venous cerebral blood volume, Resting-state functional connectivity, Bolus arrival time

2. Ngen EJ, Bar-Shir A, Jablonska A, Liu G, Song X, Ansari R, Bulte JW, Janowski M, Pearl M, Walczak P, Gilad AA. Imaging the DNA alkylator melphalan by CEST MRI: an advanced approach to theranostics. Mol Pharm. 2016 Sep 6;13(9):3043-53. doi: 10.1021/acs.molpharmaceut.6b00130.
Key words: CEST, MRI, drug imaging, melphalan, theranostics, therapeutic response assessment
PMID: 27398883

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November 2019 articles:
Changes in HSR Recertification
Research Billing Buzz eNewsletter - November 2019
Update on Insurance and Research Participant Financial Responsibility Information Sheet: Signature No Longer Required
Change in JHM IRB Review Fees for Commercially-Funded Studies
Data and Safety Monitoring Board Training Manual Now Available
Good Clinical Practice (GCP) Fundamentals: Understanding and Applying GCP to Human Subject Research
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Clinical Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Point of Contact for NIH Loan Repayment Program
Michael J. Fox Foundation (MJFF) Challenge
Point of Contact for NIH Loan Repayment Program
JHU SOM Update on NIH Policy on Foreign Involvement
Disclosure of Payments from Foreign Educational Institutions and Government Agencies
Institutional Letter of Support Required for Institutional Training Grant Applications
Notice to the Johns Hopkins Community Regarding the National Science Foundation Grant Reporting Requirement for Harassment Findings and Actions
Prohibited Mention of Prior Review for New Replacement Applications
NIH Policy on Foreign Component Involvement
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants

This Month's Departmental Listings

Upcoming Deadlines for November, December and January

JHU School of Medicine Core Showcase
November Events at the Genetics Research Core Facilitys


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