Web notes  

November 2018

Neuroscience Archives

1. Leech KA, Day KA, Roemmich RT, Bastian AJ. Movement and perception recalibrate differently across multiple days of locomotor learning. J Neurophysiol 2018 Sep 5. doi: 10.1152/jn.00355.2018. [Epub ahead of print].
Key words: locomotor, learning

2. Li Q, Qian C, Zhou FQ. Investigating mammalian axon regeneration: in vivo electroporation of adult mouse dorsal root ganglion. J Vis Exp. 2018 Sep 1;(139).
Key words: vivo, electroporation, mouse, ganglion

3. Sabbagh MF, Heng JS, Luo C, Castanon RG, Nery JR, Rattner A, Goff LA, Ecker JR, Nathans J. Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. Elife. 2018 Sep 6;7. pii: e36187.
Key words: transcriptional, epigenomic, landscapes, endothelial

4. Wang XW, Li Q, Liu CM, Hall PA, Jiang JJ, Katchis CD, Kang S, Dong BC, Li S, Zhou FQ. Lin28 signaling supports mammalian PNS and CNS axon regeneration. Cell Rep. 2018 Sep 4;24(10):2540-2552.e6.
Key words: Lin28, mammalian, regeneration

1. Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic control of spontaneous activity in the developing auditory system. Neuron. 2018 Aug 8;99(3):511-524.e5. doi: 10.1016/j.neuron.2018.07.004. Epub 2018 Aug 1.
Key words: homeostatic, spontaneous, activity, auditory

2. Cherry-Allen KM, Statton MA, Celnik PA, Bastian AJ. A dual-learning paradigm simultaneously improves multiple features of gait post-stroke. Neurorehabil Neural Repair, 2018 Aug 7;1545968318792623. doi:10.1177/1545968318792623. [Epub ahead of print].
Key words: gait post-stroke

3. Chin SG, Maguire SE, Huoviala P, Jefferis GSXE, Potter CJ. Olfactory neurons and brain centers directing oviposition decisions in drosophila. Cell Rep. 2018 Aug 7;24(6):1667-1678. doi: 10.1016/j.celrep.2018.07.018.
Key words: olfactory, oviposition

4. Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL. Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. J Comp Neurol. 2018 Aug 3. doi: 10.1002./cne.24507. [Epub ahead of print].
Key words: accessory, optic, system, Sema6A

5. Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S. Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.
Dev Biol. 2018 Jul 29. pii: S0012-1606(18)30451-2. doi: 10.1016/j.ydbio.2018.07.021. [Epub ahead of print].
Key words: Wnt, nucleogenesis, hypothalamus

6. Saunders BT1,2,3, Richard JM4,5,6, Margolis EB7, Janak PH8,9,10. Dopamine Neurons Create Pavlovian Conditioned Stimuli with Circuit-defined Motivational Properties.
Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.
Key words: dopamine, Pavlovian, motivational

7. Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su SM, Palermo AT, Bergles DE, Burns JC, Müller U. Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. Cell. 2018 Jul 30. pii: S0092-8674(18)30902-4. doi: 10.1016/j.cell2018.07.008. [Epub ahead of print].
Key words: hair, cell, mechanotransduction, activity

8. Therrien AS, Wolpert DM, Bastian AJ. Increasing motor noise impairs reinforcement learning in healthy individuals. eNeuro. 2018 Aug 13;5(3). pii: ENEURO.0050-18.2018. doi: 10.1523/ENEURO.0050-18.2018.
Key words: motor noise, reinforcement learning

9. Xin W, Schuebel KE, Jair KW, Cimbro R, De Biase LM, Goldman D, Bonci A. Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling.
Neuropsychopharmacology. 2018 Jul 13. doi: 10.1038/s41386-018-0151-4. [Epub ahead of print].
Key words: midbrain, astrocytes, dopamine

10. Zimmet AM, Cowan NJ, Bastian AJ. Patients with cerebellar ataxia do not benefit from limb weights.
Cerebellum. 2018 Aug 1. doi: 10.1007/s12311-018-0962-1. [Epub ahead of print].
Key words: Cerebellar Ataxia, limb weights

1. Nagpal L, Fu C, Snyder SH. Inositol hexakisphosphate kinase-2 in cerebellar granule cells regulates Purkinje-cells and motor coordination via protein 4.1N. J Neurosci. 2018 Jul 13. pii: 1165-18. doi: 10.1523/JNEUROSCI.1165-18.2018. [Epub ahead of print].
Key words: inositol hexakisphosphate kinase-2, Purkinje

2. Tran T, Gallagher M, Kirkwood A. Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats. Neurobiol Aging. 2018 Jun 12;70:92-101. doi: 10.1016/j.neurobiolaging.2018.06.008. [Epub ahead of print].
Key words: postsynaptic inhibitory strength, rats

3. Wu D, Faria AV, Younes L, Ross CA, Mori S, Miller MI. Whole-brain segmentation and change-point analysis of anatomical brain MRI-application in premanifest Huntington's Disease. J Vis Exp. 2018 Jun 9;(136). doi: 10.3791/57256.
Key words: anatomical, MRI, Huntington's

1. Kisner A, Slocomb JE, Sarsfield S, Zuccoli ML, Siemian J, Gupta JF, Kumar A, Aponte Y. Electrophysiological properties and projections of lateral hypothalamic parvalbumin positive neurons.
PLoS One. 2018 Jun 12;13(6):e0198991. doi: 1371/journal.pone.0198991. eCollection 2018.
Key words: lateral hypothalamic, neurons

2. Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH. A Non-canonical feedback circuit for rapid interactions between somatosensory cortices. Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.
Key words: feedback, circuit, somatosensory

3. Tang X, Luo Y, Chen Z, Huang N, Johnson HJ, Paulsen JS, Miller MI. A fully-automated subcortical and ventricular shape generation pipeline preserving smoothness and anatomical topology.
Front Neurosci. 2018 May 17;12:321. doi: 10.3389/fnins.2018.00321. eCollection 2018.
Key words: subcortical ventrical, shape, generation, pipeline

1. Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A. Two distinct mechanisms of experience-dependent homeostasis.
Nat Neurosci. 2018 May 14. doi: 10.1038/s41593-018-0150-0. [Epub ahead of print].
Key words: experience-dependent, homeostasis

2. Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH. Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1. Sci Rep. 2018 May 4;8(1):7039. doi: 10.1038/s41598-018-25468-8.
Key words: germ cell, Sertoli, inositol hexakisphosphate


3. Li RC, Lin CC, Ren X, Wu JS, Molday LL, Molday RS, Yau KW. Ca2+-activated C1 current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci USA. 2018 May 7. pii: 201803443. doi: 10.1073/pnas.1803443115. [Epub ahead of print].
Key words: C1 current, olfactory receptor neurons

4. Ramos-López P, Irizarry J, Pino I, Blackshaw S. Antibody specificity profiling using protein microarrays.
Methods Mol Biol. 2018;1785:223-229. doi: 10.1007/978-1-4939-7841-1_14.
Key words: antibody, profiling

1. Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [epub ahead of print].
Key words: locomotor, learning

2. de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development. 2018 Apr 12. pii: dev. 159970. doi: 10.1242/dev.159970. [Epub ahead of print}.
Key words: Lhx2, balance, neurogenesis, gliogenesis, retina

3. Dresselhaus EC, Boersma MCH, Meffert M. Targeting of NF-?B to dendritic spines in required for synaptic signaling and spine development. J Neurosci. 2018 Mar 19; pii: 266-16. doi: 10.1523/JNEUROSCI.2663-16.2018. [Epub ahead of print].
Key words: NF-?B

4. Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandy A, Huganir RL. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci USA 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.

5. Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 Mar 19. doi: 10.1038/s41593-018-0121-5. [Epub ahead of print].
Key words: myelin, remodeling, oligodendrogenesis, cortex

6. Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018 Mar 29. pii: eaan4665. doi: 10.1126/science.aan4665. [Epub ahead of print].
Key words: dimethyl fumarate, GAPDH, immunity

7. Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Elife. 2018 Mar 29;7. pii: e34829. doi: 10.7554/eLife.34829.
Key words: oligodendrocytes, potassium, seizure

8. Machamer JB, Woolums BM, Fuller GG, Lloyd TE. FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons. Brain Res. 2018 Apr 3. pii: S0006-8993(18)30180-X. doi: 10.1016/j.brainres.2018.03.037. [Epub ahead of print].
Key words: FUS, synaptic, hyperexcitability

9. Newman EA, Kim DW, Wan J, Wang J, Qian J, Blackshaw S. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Apr 18. pii: S00012-1606(17)30906-5. doi: 10.1016/j.ydbio.2018.04.012. [Epub ahead of print].
Key words: Foxd1, hypothalamic, subtypes

10. Richard JM, Stout N, Acs D, Janak PH. Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure. Elife. 2018 Mar 22;7. pii: e33107. doi: 10.7554/eLife.33107.
Key words: reward, seeking, behavior

11. Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S. A Toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods. 2018 Mar 19. doi: 10.1038/nmeth.4632. [Epub ahead of print]
Key words: immunoprecipitation, grade, monoclonal, human, transcription

12. Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018 Apr 18;9(1):1526. doi:10.1038/s41467-108-03948-9.
Key words: neurobehavioral, redox,homeostasis

13. Xie T, Ho MCW, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, WU M. A genetic toolkit for dissecting dopamine circuit function in Drosophila. Cell Rep. 2018 Apr 10;23(2):652-665. doi: 10.1016/j.celrep.2018.03.68.
Key words: genetic toolkit, dopamine, Drosophila

14. Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress granule assembly disrupts nucleocytoplasmic transport. Cell. 2018 Apr 2. pii: S0092-8674 (18)30305-2. doi: 10.1016/j.cell.2018.03.025. [Epub ahead of print].
Key words: stress, granule, nucleocytoplasmic

1. Chung T, Tian Y, Walston J, Hoke A. Increased single fiber jitter level is associated with reduction in motor function with aging. Am J Phys Med Rehabil. 2018 Mar 1. doi: 10.1097/PHM.0000000000000915. [Epub ahead of print].
Key words: single, fiber, jitter

2. Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. J Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [Epub ahead of print].
Key words: locomotor, training

3. Oldach LM, Gorshkov K, Mills WT 4th, Zhang J, Meffert MK. A biosensor for MAPK-dependent Lin28 signaling. Mol Biol Cell. 2018 Mar 14. pii: mbc.E17-08-0500. doi: 10.1091/mbc.E17-08-0500. [Epub ahead of print].
Key words: MAPK, Lin28

4. Posporelis S, Coughlin JM, Marsman A, Pradhan S, Tanaka T, Wang H, Varvaris M, Ward R, Higgs C, Edwards JA, Ford CN, Kim PK, Lloyd AM, Edden RAE, Schretlen DJ, Cascella NG, Barker PB, Sawa A. Decoupling of brain temperature and glutamate in recent onset of schizophrenia: A 7T proton magnetic resonance spectroscopy study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Mar;3(3):248-254. doi: 10.1016/j.bpsc.2017.04.003. Epub 2017 21.
Key words: schizophrenia, glutamate, brain temperature, magnetic resonance spectroscopy

1. Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to brochoconstriction and airway hyper-responsiveness. Nat Neurosci. 2018 Feb 5. doi: 10.1038/s41593-018-0074-8. [Epub ahead of print].
Key words: mrgprs, bronchoconstriction, airway

2. Sasikumar D, Emeric E, Stuphorn V, Connor CE. First-pass processing of value cues in the ventral visual pathway. Curr Biol. 2018 Feb 19;28(4):538-548.e3. doi: 10.1016/j.cub.2018.01.051. Epub 2018 Feb 8.
Key words: processing, cues, visual, pathway

1. Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA. Variation in activity state, axonal projection, and position define the transcriptional identity of individual neocortical projection neurons.
Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.
Key words: transcriptional, individual, necortical, projection

2. Fischbach-Weiss S, Reese RM, Janak PH. Inhibiting mesolimbic dopamine neurons reduces the initiation and maintenance of instrumental responding. Neuroscience 2017 Dec 15. pii: S0306-4522(17)30874-6. doi: 10.1016/j.neuroscience.2017.12.003. [Epub ahead of print].
Key words: dopamine, instrumental, responding

3. Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1? degradation. Circ Res. 2017 Dec 26. pii: CIRCRESAHA. 117.311983. doi: 10.1161/CIRCRESAHA.117.311983. [Epub ahead of print].
Key words: inositol, multikinase, angiogenesis, HIF


4. Leech KA, Roemmich RT, Bastian AJ. Creating flexible motor memories in human walking. Sci Rep. 2018 Jan 8;8(1):94. doi: 10.1038/s41598-017-18538-w.
Key words: motor, memories, walking

5. Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley P. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Hum Mol Genet. 2017 Dec 18. doi: 10.1093/hmg/ddx426. [Epub ahead of print].
Key words: FRMPD4, intellectual, disability, spine

1. de Melo J, Blackshaw S. In vivo electroporation of developing mouse retina. Methods Mol Biol. 2018;1715:101-111. doi: 1007/978-1-4939-7522-8_8.
Key words: electroporation, retina

2. Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder S. TRPV1 is a physiological regulator of ?-opioid receptors. Proc Natl Acad Sci USA. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print].
Key words: TRPV1, opiod, receptors

1. Hu B, Niebur E. A Recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Dec;43(3):227-243. doi: 10.1007/s10827-017-0659-3. Epub 2017 Sep 19.
Key words: neural, model, contour, integration

2. Tward DJ, Miller MI. On the complexity of human neuroanatomy at the millimeter morphome scale: developing codes and characterizing entropy indexed to spatial scale. Front Neurosci. 2017 Oct 18;11:577. doi: 10.3389/fnins.2017.00577. eCollection 2017.
Key words: human neuroanatomy, entropy indexed

3. Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron. 2017 Nov 14. pii: S0896-6273(17)31021-8. doi: 10.1016/j.neuron.2017.10.029. [Epub ahead of print]
Key words: homeostatic, scaling, cortical, neurons

4. WU JS, Vyas P, Glowatzki E, Fuchs PA. Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrp?) and tyrosine hydroxylas (Th) in Type II afferent neurons of the mouse cochlea. J Comp Neurol. 2017 Oct 21. doi: 10.1022/cne.24341. [Epub ahead of print]
Key words: calcitonin, afferent, neurons, cochlea

1. Gillary G, Heydt RV, Niebur E. Short-term depression and transient memory in sensory cortex.
J. Comput. Neurosci. 2017 Oct 13. doi: 10.1007/s10827-017-0662-8. [Epub ahead of print].
Key words: memory, sensory, cortex

2. Ko HK, von der Heydt R. Figure-ground Organization in the visual cortex: does meaning matter?
J Neurophysiol. 2017 Oct 4:jn.00131.2017. doi: 10.1152/jn.00131.2017. [Epub ahead of print].
Key words: figure, ground, organization

3. Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ. Enhanced stem cell differentiation and immunopurification of genome engineered human retinal ganglion cells.
Stem Cells Transl Med. 2017 Oct 10. doi: 10.1002/sctm.17-0059. [Epub ahead of print].
Key words: immunopurification, human, retinal, ganglion, cells

4. Tward DJ, Sicat CS, Brown T, Bakker A, Gallagher M, Albert M, Miller M. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.
Alzheimers Dement (Amst). 2017 Sep 14; 9:41-50. doi:10.1016/j.dadm.2017.07.005. eCollection 2017.
Key words: entorhinal, longitudinal, diffeomorphometry

5. Vadaele Y, Pribut HJ, Janak PH. Lever insertion as a salient stimulus promoting insensitivity to outcome devaluation. Front Integr Neurosci. 2017 Sep 27;11:23. doi: 10.3389/fnint.2017.00023. eCollection 2017.
Key words: salient, stimulus, devaluation

1. Antony BJ, Kim BJ, Lang A, Carass A, Prince JL, Zack DJ. Automated segmentation of mouse OCT volumes (ASiMOV): validation & clinical study of a light damage model. PLoS One. 2017 Aug 17;12(8):e0181059. doi: 10.1371/journal.pone.018159. eCollection 2017.
Key words: automated segmentation, validation & clinical

2. Hu B, Niebur E. A recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Sep 19. doi: 10.1007/s10827-017-0659-3. [Epub ahead of print].
Key words: neural model, proto-object, based contour integration

3. Jeong S, Yang DS, Hong YG, Mitchell SP, Kolodkin AL. Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila. Proc Natl Acad Sci U S A. 2017 Sep 11. pii: 201713010. doi: 10.1073/pnas.1713010114. [Epub ahead of print]
Key words: semaphoring-1a reverse signaling, Drosophila

4. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease. J Neurosci. 2017 Sep 13;37(37):9037-9053. doi: 10.1523/JNEUROSCI.0811-17.2017. Epub 2017 Aug 17.
Key words: excitability, amyotrophic, lateral sclerosis, corticospinal

5. Kwon SE, Tsytsarev V, Erzurumlu RS, O'Connor DH. Organization of orientation-specific Whisker deflection responses in layer 2/3 of mouse somatosensory cortex. Neuroscience. 2017 Aug 4. pii: S0306-4522(1)30553-5. doi: 10.1016/j.neuroscience.2017.07.067. [Epub ahead of print]
Key words: orientation, somatosensory, cortex

6. Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham JR, Pachinis V, Hattar S, Song J, Brown SP, Blackshaw S. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature. 2017 Aug 31;548(7669):582-587. doi: 10.1038/nature23663. Epub 2017 Aug 23.
Key words: Lhx6, GABA, Sleep

7. Statton MA, Vazquez A, Morton SM, Vasudevan EVL, Bastian AJ. Making sense of cerebellar contribution to perceptual and motor adaptation. Cerebellum. 2017 Aug 24. doi: 10.1007/s12311-017-0879-0.
Key words: cerebellar, contribution, motor adaption

8. Turkiew E, Falconer D, Reed N, Höke A. Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy. J Peripher Nerv Syst. 2017 Sep;22(3): 162-171. doi: 10.1111/jns.12219.
Key words: Sarm1, neuroprotective, peripheral neuropathy

1. Cho C, Smallwood PM, Nathans J. Reck and Gpr124 are essential receptor cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation. Neuron. 2017 Aug 30;95(5):1221-1225.
Key words: Reck, Gpr124, Wnt7a/Wnt7b, angiogenesis

2. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease. J Neurosci. 2017 Aug 17. pii: 0811-17. doi: 10.1523/JNEUROSCI.0811-17.2017. [Epub ahead of print]
Key words: excitability, amyotrophic, lateral, sclerosis, corticospinal

3. Millan EZ, Kim HA, Janak PH. Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior. Neuroscience. 2017 Jul 28;360:106-117. doi:10.1016/j.neuroscience.2017.07.044. [Epub ahead of print]
Key words: optogentic, activation, amygdala, alcohol, consummatory

1. De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, Zhang HY, Liu QR, Shen H, Xi ZX, Goldman D, Bonci A. Local cues establish and maintain region-specific phenotypes of basal ganglia microglia. Neuron. 2017 Jul 19;95(2):341-356.e6. doi: 10.1016/j.neuron.2017.06.020. Epub 2017 Jul 6.
Key words: basal ganglia, microglia

2. Fraser KM, Janak PH. Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking. Eur J Neurosci. 2017 Jul 12. doi:10.1111/enj.13642. [Epub ahead of print]
Key words: dopamine, dorsal lateral striatum

3. Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.
Key words: ALS, C9orf72

4. Miller SJ, Rothstein JD. 3D printer generated tissue iMolds for cleared tissue using single- and multi-microscopy for deep tissue evaluation. Biol Proced Online. 2017 Jul 5;19-7. doi: 10.1186/s12575-017-0057-2. eCollection 2017.
Key words: 3D printer; CLARITY; Cleared tissue; Medicine; Microscopy; Tissue molds

5. Vasavda C, Zaccor NW, Scherer PC, Sumner CJ, Snyder SH. Measuring G-protein-coupled receptor signaling via radio-labeled GTP binding. J Vis Exp. 2017 Jun 9;(124). doi: 10.3791/55561.
Key words: protein-coupled receptor, GTP binding

6. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. Synergistic signaling by light and acetylcholine in mouse iris sphincter muscle. Curr Biol. 2017 Jun 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.
Key words: light, acetylcholine, iris sphincter

7. Ye Z, Goutman JD, Pyott SJ, Glowatzki E. MGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea. J Physiol. 2017 Jun 1;595(11):3483-3495. doi: 10.1113/JP272604.
Key words: mGluR1, inner hair cells, cochlea

1. Cashman CR, Hoke A. Deficiency of adaptive immunity does not interfere with Wallerian degeneration.
PLoS One. 2017 May 5:12(5):e0177070. doi: 10.1371/journal.pone.0177070. eCollection 2017.
Key words: adaptive, immunity, Wallerian

2. Cox E, Hwang W, Uzoma I, Hu J, Guzzo CM, Jeong J, Matunis MJ, Qian J, Zhu H, Blackshaw S. Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex. Mol Cell Proteomics. 2017 May;16(5):812-823. doi: 10.1074/mcp.M116.063719. Epub 2017 Mar 2.
Key words: SUMO, chromatin

3. Harraz MM, Snyder SH. Antidepressant actions of ketamine mediated by the mechanistic target of rapamycin, nitric oxide, and rheb. Neurotherapeutics. 2017 Jun 13. doi: 10.1007/s13311-017-0540-0. [Epub ahead of print].
Key words: GAPDH; Glutamate receptor; Ketamine; Nitric oxide; Rheb; mTOR

4. Jeck DM, Qin M, Egeth H, Niebur E. Attentive pointing in natural scenes correlates with other measures of attention. Vision Res. 2017 Jun;135:54-64. doi: 10.1016/j.visres.2017.04.001. Epub 2017 May 8.
Key words: Attention; Fixations; Interest points; Natural scenes; Pointing; Probability density estimation; Probability distributions; Salience; Saliency map; Tapping

5. Kajstura TJ, Dougherty SE, Linden DJ. Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. J Neurosci Res. 2017 May 9. doi: 10.1002/jnr.24059. [Epub ahead of print.]
Key words: controlled cortical impact; regeneration; serotonin; traumatic brain injury

6. Li S, Raychaudhuri S, Watanabe S. Flash-and-freeze: a novel technique to capture membrane dynamics with electron microscopy. J Vis Exp. 2017 May 1;(123). doi: 10.3791/55664.
Key words: flash-and-freeze, electron microscopy

7. Severson KS, Xu D, Van de Loo M, Bai L, Ginty DD, O'Connor DH5 Active touch and self-motion encoding by Merkel cell-associated afferents. Neuron. 2017 May 3;94(3):666-676.e9. doi: 10.1016/j.neuron.2017.03.045. Epub 2017 Apr 20.
Key words: active sensation; barrel cortex; neural coding; perception; primary afferents; proprioception; reafferent; sensorimotor integration; somatosensation; whisker system

8. Turkiew E, Falconer D, Reed N, Hoke A. Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy. J Peripher Nerv Syst. 2017 May 9. doi:10.1111/jns.12219. [Epub ahead of print]
Key words: Sarm1, peripheral neuropathy.

9. Wang Q, Yu WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. Synergistic signaling by light and acetylcholine in mouse iris sphincter muscle. Curr Biol. 2017 June 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.
Key words: iris sphincter muscle; melanopsin; pupillary light reflex

10. Xie X, Tabuchi M, Brown MP, Mitchell SP, Wu MN, Kolodkin AL. The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of the ectopic synaptic connections. Elife. 2017 Jun 20;6. pii:e25328. doi: 10.7554/eLife.25328. [Epub ahead of print]
Key words: laminar, drosophila, connections

11. Ye Z, Goutman JD, Pyott SJ, Glowatzki E. mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea. J Physiol. 2017 Jun 1;595(11):3483-3495. doi: 10.1113/JP272604. Epub 2017 Apr 21.
Key words: mGluR1, hair, cells

1. Grima JC, Daigle J2, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LP, Thompson LM, Lloyd TE, Ross CA, Rothstein JD. Mutant Hungtingtin disrupts the nuclear pore complex. Neuron. 2017 Apr 5;94(1):93-107.e6. doi: 10.1016/j.neuron.2017.03.023.
Key words: C9ORF72; Huntington's disease; KPT-350; O-GlcNAc; RAN translation; Thiamet-G; induced pluripotent stem cell; neurodegeneration; nuclear porecomplex; nucleocytoplasmic transport

2. Sell GL, Schaffer TB, Margolis SS. Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice. J Clin Invest. 2017 Mar 27. pii: 85504. doi: 10.1172/JC185504. [Epub ahead of print]
Key words: Ephexin5, Alzheimer's, mice

3. Vaziri S, Connor CE. Representation of gravity-aligned scene structure in ventral pathway visual cortex. Curr Biol. 2016 Mar 21;26(6):766-74. doi: 10.1016/j.cub.2016.01.022. Epub 2016 Feb 25.
Key words: gravity, scene, visual cortex

1. Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, Niranjan T, Schwartz CE, Wang T, Huganir RL. GRASP1 regulates synaptic plasticity and learning through endosomal recycling of AMPA receptors.
Neuron. 2017 Mar 8. pii: S0896-6273(17)30139-3. doi: 10.1016/j.neuron.2017.02.031.
Key words: GRASP1, recycling, AMPA

2. Cox E, Hwang W, Uzoma I, Hu J, Guzzo C, Jeong J, Matunis M, Qian J, Zhu H, Blackshaw S. Global analysis of SUMO-binding proteins Identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex. Mol Cell Proteomics. 2017 Mar 2. pii: mcp.M116.063719. doi: 10.1074/mcp.M116.063719. [Epub ahead of print]
Key words: SUMOylation, chromatin, remodeling

3. GoodSmith D, Chen X, Wang C, Kim SH, Song H, Burgalossi A, Christian KM, Knierim JJ. Spatial representations of granule cells and mossy cells of the dentate gyrus. Neuron. 2017 Feb 8;93(3):677-690.e5. doi: 10.1016/j.neuron.2016.12.026. Epub 2017 Jan 26.
Key words: spatial, representations, mossy, dentate

4. Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G Protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21.
Key words: Mas-related G protein-coupled receptor X

5. Ramachandran KV, Margolis SS. A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function. Nat Struct Mol Biol. 2017 Mar 13. doi:10.1038/nsmb.3389. [Epub ahead of print]
Key words: proteasome, complex, neuronal, function

6. Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF. Increased sparsity of hippocampal CA1 neuronal ensembles in a mouse model of Down syndrome assayed by arc expression.
Front Neural Circuits. 2017 Feb 3;11:6. doi:10.3389/fncir.2017/00006. eCollection 2017.
Key words: down syndrome, Arc.

7. Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord. Neuron. 2017 Feb 22;93(4):840-853.e5. doi: 10.1016/j.neuron.2017.01.012.
Key words: pain, itch, spinal cord

8. Weeks HM, Therrien AS, Bastian AJ. Proprioceptive localization deficits in people with cerebellar damage. Cerebellum 2017 Apr;16(2):427-437. doi: 10.1007/s12311-016-0819-4.
Key words: proprioceptive, localization, cerebellar

1. Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes. Neuron. 2017 Feb 8;93(3):587-605.e7.
Key words: calcium transients, astrocyte

2. Amen AM, Ruiz-Garzon CR, Shi J, Subramanian M, Pham DL, Meffert MK. A rapid induction mechanism for Lin28a in trophic responses. Mol Cell. 2017 Feb 2;65(3):490-503.e7.
Key words: rapid, induction, Lin28a, trophic

3. Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, Sockanathan S. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017 Jan 19;12(1):8. doi: 10.1186/s13024-017-0148-1.
Key words: GDE2, neuronal survival, spinal, cord

4. Chang H, Smallwood PM, Williams J, Nathans J. Intramembrane proteolysis of astrotactins.
J Biol Chem. 2017 Jan 18. pii: jbc.M166.768077. doi: 10.1074/jbc.M116.768077. [Epub ahead of print]
Key words: intramembrane, proteolysis, astrotactins

5. Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.
Key words: Homer1a, homeostatic, sleep

6. Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Arraz MM, Snyder SH. Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via ?-actinin and focal adhesion kinase.
Proc Natl Acad Sci U S A. 2017 Feb 2. pii: 201700165. doi: 10.1073/pnas.1700165114. [Epub ahead of print].
Key words: neuronal, migration, hexakisphosphate kinase 1

7. Lagerlöf O, Hart GW, Huganir RL. O-GlcNAc transferase regulates excitatory synapse maturity.
Proc Natl Acad Sci U S A. 2017 Jan 31. pii: 201621367. doi: 10.1073/pnas.1621367114.
Key words: O-GlcNAc transferase, synapse

8. Yue WW, Frederiksen R, Ren X, Luo D, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket.
Elife. 2017 Feb 10;6. pii: e18492. doi: 10.7554/eLife.18492.
Key words: spontaneous, activation, visual pigments

1. Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S Blackshaw S. An LHX1-regulated transcriptional network controls sleep/wake coupling and thermal resistance of the central circadian clockworks. Curr Biol. 2017 Jan 9;27(1):128-136. doi: 10.1016/j.cub.2016.11.008. Epub 2016 Dec 22.
Key words: transcriptional network, central circadian clockworks

2. Chhabra A, Carrino JA, Farahani SJ, Thawait GK, Sumner CJ, Wadhwa V, Chaudhary V, Lloyd TE. Whole-body MR neurography: prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease. J Magn Reson Imaging. 2016 Dec;44(6):1513-1521. doi:10.1002/jmri.25293. Epub 2016 Apr 29.
Key words: neurography, polyneuropathy, Charcot-Marie-tooth

3. Miller SJ, Zhang PW, Glatzer J, Rothstein JD. Astrogial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model. J Neurogenet. 2016 Dec 25;1-12. doi: 10.1080/01677063.2016.1260128. [Epub ahead of print].
Key words: astroglial transcriptome, ALS, SOD1

4. Savelli F, Luck JD, Knierim JJ. Framing of grid cells within and beyond navigation boundaries. Elife. 2017 Jan 13;6. pii:e21354. doi:10.7554/eLife.21354. [Epub ahead of print].
Key words: grid cells, navigation

5. Williford JR, von der Heydt R. Figure-ground organization in visual cortex for natural scenes.
eNeuro. 2016 Dec 29;3(6). pii: ENEURO.0127-16.2016. doi: 10.1523/ENEURO.0127-16.2016.
Key words: figure-ground organization, visual cortex

1 Corbit LH, Janak PH. Changes in the influence of alcohol-paired stimuli on alcohol seeking across extended training. Front Psychiatry, 2016 Oct 10;7:169. eCollection 2016.
Key words: Pavlovian-instrumental transfer; ethanol; habit learning; outcome devaluation; stimuli

2. Finley JM. Bastian AJ. Associations between foot placement asymmetries and metabolic cost of transport in hemiparetic gait. Neurorehabil Neural Repair. 2016 Oct 20. pii: 154968316675428. [Epub ahead of print]
Key words: asymmetry; locomotion; metabolic cost; stroke

3. Gu Y, Huganir RL. Identification of the SNARE complex mediating the exocytosis of NMDA receptors.
Proc Natl Acad Sci USA. 2016 Oct 25;113(43):12280-12285. Epub 2016 Oct 6.
Key words: NMDA receptor; Rab; SNARE; TIRFM; constitutive exocytosis

4. Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 1;143(21):3994-4002. Epub 2016 Sep 15.
Key words: lens, development, FGFs

1. Gillary G, Niebur E. The edge of stability: response times and delta oscillations in balanced networks.
PLoS Comput Biol 2016 Sep 30;12(9):e1005121. doi:10.1371/journal.pcbi.1005121.
Key words: delta oscillations, networks

2. Kwon SE, Yang H, Minamisawa G, O'Connor DH. Sensory and decision-related activity propagate in a cortical feedback loop during touch perception. Nat Neurosci 2016 Sep;19(9):1243-9. doi: 10.1038/nn.4356.
Key words: cortical feedback, touch perception

3. Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-time imaging reveals properties of glutamate-induced Arc/Arg 3.1 translation in neuronal dendrites. Neuron. 2016 Aug 3;91(3):561-73. doi: 10.1016/j.neuron.2016.06.017.
Key words: imaging, arc, dendrites

4. Riabinina O, Potter CJ. The Q-system: a versatile expression system for Drosophila. Methods Mol Biol. 2016;1478:53-78.
Key words: Q-system, drosophila

5. Riabinina O, Task D, Marr E, Lin CC, Alford R, O'Brochta DA, Potter CJ. Organization of olfactory centres in the malaria mosquito Anopheles gambiae. Nat Commun. 2016 Oct 3;7:13010. doi: 10.1038/ncomms13010.
Key words: olfactory, malaria, Anopheles

6. Roemmich RT, Long AW, Bastian AJ. Seeing the errors you feel enhances locomotor performance but not learning. Curr Biol. 2016 Oct 24;26(20):2707-2716.
Key words: adaptation; feedback; gait; locomotion; motor learning; split-belt treadmill; walking

7. Wang Y, Williams J, Rattner A, Wu S, Bassuk AG, Goffinet AM, Nathans J. Patterning of papillae on the mouse tongue: a system for the quantitative assessment of planar cell polarity signaling.
Dev Biol. 2016 Sep 6. pii: S0012-1606(16)30439-0. doi: 10.1016/j.ydbio.2016.09.004. [Epub ahead of print].
Key words: papillae, planar, cell, polarity

8. Weng YL, Joseph J, An R, Song H, Ming GL. Epigenetic regulation of axonal regenerative capacity.
Epigenomics. 2016 Oct;8(10):1429-1442.
Key words: epigenetic, axonal, regenerative

1. Ambrose RE, Pfeiffer BE, Foster DJ. Reverse Replay of Hippocampal Place Cells Is Uniquely Modulated by Changing Reward. Neuron. 2016 Sep 7; 91(5):1124-36. doi: 10.1016/j.neuron.2016.07.047.
Key words: replay, hippocampal, reward

2. de Melo J, Clark BS, Blackshaw S. Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis. Sci Rep. 2016 Sep 8;6:32757. doi: 10.1038/srep32757.
Key words: Lhx2, gliogenesis

3. Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M,Guan Y, Spray DC,, Dong X. Coupled activation of primary sensory neurons contributes to chronic pain. Neuron. 2016 Sep 7;91(5):1085-96. doi: 10.1016/j.neuron.2016.07.044.
Key words: sensory, neurons, pain

4. Lin CC, Potter CJ. Non-Mendelian dominant maternal effects caused by CRISPR/Cas9 transgenic components in Drosophila melanogaster. G3 (Bethesda). 2016 Sep 16. pii: g3.116.034884. doi: 10.1534/g3.116.034884. [Epub ahead of print]
Key words: CRISPR/Cas9, transgenic, Drosophila

5. Lin CC, Riabinina O, Potter CJ. Olfactory behaviors assayed by computer tracking of Drosophila in a four-quadrant olfactometer. J Vis Exp. 2016 Aug 20;(114). doi: 10.3791/54346.
Key words: olfactory, behaviors, drosophila, olfactometer

6. Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Sep 15. pii: dev.137760. [Epub ahead of print]
Key words: lens, neuroretinal, FGFs

7. Wang Y, Williams J, Rattner A, Wu S, Bassuk AG, Goffinet AM, Nathans J. Patterning of papillae on the mouse tongue: a system for the quantitative assessment of planar cell polarity signaling. Dev Biol. 2016 Sep 6. pii: S0012-1606(16)30439-0. doi: 10.1016/j.ydbio.2016.09.004. [Epub ahead of print]
Key words: patterning, papillae, polarity

1. Diering GH, Heo S, Hussain NK, Liu B, Huganir RL. Extensive Phosphorylation of AMPA Receptors in Neurons. Proc Natl Acad Sci USA. 2016 Aug 16;113(33);E4920-7. doi:10.1073/pnas.1610631113. Epub 2016 Aug 1.
Key words: phosphorylation, AMPA, receptors

2. Jin Y, , Dougherty SE, Wood K, Sun L, Cudmore RH, Abdalla A, Kannan G, Pletnikov M, Hashemi P, Linden DJ. Regrowth of serotonin axons in the adult mouse brain following injury. Neuron. 2016 Aug 17;91(4):748-62/ doi:10.1016/j.neuron.2016.07.024. Epub 2016 Aug.
Key words: regrowth, serotonin, axons, injury

3. Kwon SE, Yang H, Minamisawa G, O'Connor DH. Sensory and decision-related activity propagate in a cortical feedback loop during touch perception. Nat Neurosci. 2016 Jul 20. doi: 10.1038/nn.4356. [Epub ahead of print].
Key words: sensory, decision, activity, touch, perception

4. Miller SJ, Rothstein JD. Astroglia in thick tissue with super resolution and cellular reconstruction. PLoS One. 2016 Aug 5;11(8):e0160391. doi: 1371/journal.pone.0160391. eCollection 2016.
Key words: astroglia, super resolution

5. Wagatsuma N, von der Heydt R, Niebur E. Spike synchrony generated by modulatory common input through NMDA-type synapses. J Neurophysiol. 2016 Jul 13;.jn.01142.2015. doi: 10:101152/jn.01142.2015. [Epub ahead of print]
Key words: spike, synchrony, modulatory, NMDA

6. Weeks HM, Therrien AS, Bastian AJ. Proprioceptive localization deficits in people with cerebellar damage. Cerebellum. 2016 Aug 18. [Epub ahead of print]
Key words: proprioceptive, cerebellar, damage

7. Wong AL, Goldsmith J, Krakauer JW. A motor planning stage represents the shape of upcoming movement trajectories. J Neurophysiol. 2016 Aug 1;116(2):296-305. doi: 10.1152/jn.01064.2015. Epub 2016 Apr 20.
Key words: omplex action; desired trajectory; motor planning; optimal feedback control; reaction time

1. Gomez-Ramirez M, Hysaj K, Niebur E. Neural mechanisms of selective attention in the somatosensory system. J Neurophysiol. 2016 Jun 22;jn.00637.2015. doi: 10.1152/jn.00637.2015. [Epub ahead of print]
Key words: selective, attention, somatosensory

2. Lin CC, Potter CJ. Editing transgenic DNA components by inducible gene replacement in drosophila melanogaster. Genetics. 2016 Jun 22. pii: genetics.116.191783. [Epub ahead of print]
Key words: editing, transgenic, DNA, drosophila

3. Martinez-Monedero R, Liu C, Weisz C, Vyas P, Fuchs PA, Glowatzki E. GluA2-containing AMPA receptors distinguish ribbon-associated from ribbonless afferent contacts on rat cochlear hair cells.
eNeuro 2016 May 12;3(2). pii: ENEURO.0078-16.2016. doi: 10.1523//ENEURO.0078-16.2016.
Key words: GluA2, ribbon, hair cells

4. Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF. Real-time imaging reveals properties of glutamate-induced Arc/Arg 3.1 translation in neuronal dendrites. Neuron. 2016 Jul 5. pii: S0896-6273(16)30924-X. doi: 10.1016/j.neuron.2016.06.017. [Epub ahead of print]
Key words: imaging, Arc, dendrites

5. Qu L, Caterina MJ. Enhanced excitability and suppression of A-type K (+) currents in joint sensory neurons in a murine model of antigen-induced arthritis. Sci Rep. 2016 1;6:28899. doi: 10.1038/srep28899.
Key words: excitability, murine, antigen-induced, arthritis

1. Hart RP, Goff LA. Long noncoding RNAs: central to nervous system development. Int J Dev Neurosci. 2016 Jun10. pii: S0736-5748 (16) 30109-5. doi: 10.1016/j.ijdevneu.2016.06.001. [Epub ahead of print]
Key words: long noncoding, nervous system

2. Liu S, Liu Q, Tabuchi M, Wu MN. Sleep drive is encoded by neural plastic changes in a dedicated circuit.
Cell. 2016 Jun2; 165(6): 1347-60. doi: 10.1016/j.cell.2016.04.013. Epub 2016 May 19.
Key words: sleep drive, dedicated circuit

1. Evsen L, Doetzlhofer A. Gene transfer into the chicken auditory organ by in ovo micro-electroporation.J Vis Exp. 2016 Apr 17; (110). doi: 10.3791/53864.
Key words: gene transfer, auditory, in ovo micro-electroporation

2. Fu X, Shah A, Baraban JM. Rapid reversal of translational silencing: emerging role of microRNA degradation pathways in neuronal plasticity. Neurobiol Learn Mem. 2016 Apr 20. pii: S1074-7427(16)30028-4. doi: 10.1016/j.nlm.2016.04.006. [Epub ahead of print]
Key words: translational silencing, neuronal plasticity

3. Liu S, Liu Q, Tabuchi M, Wu MN. Sleep drive is encoded by neural plastic changes in a dedicated circuit.Cell. 2016 May 18. pii: S0092-8674(16)30404-4. doi: 10.1016/j.cell2016.04.013. [Epub ahead of print]
Key words: sleep drive, dedicated circuit

4. Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Yoon KJ, Jeang W, Lin L, Thakor J, Berg DA, Zhang C, Kang E, Chickering M, Nauen D, Ho CY, Wen Z, Christian KM, Shi PY, Maher BJ, Wu H, Jin P, Tang H, Song H, Ming GL. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell. 2016 May 19;165(5):1238-54. doi: 10.1016/j.cell2016.04.032. Epub 2016 Apr 22.
Key words: organoids, mini-bioreactors, ZIKV

5. Zhang K, Grima JC, Rothstein JD, Lloyd TE. Nucleocytoplasmic transport in C9orf72-mediated ALS/FTD. Nucleus. 2016 Apr 26; 1-6. [Epub ahead of print]
Key words: nucleocytoplamic transport, C9orf72, ALS/FTD

1. Musselman KE, Roemmich RT, Garrett B, Bastian AJ. Motor learning in childhood reveals distinct mechanisms for memory retention and re-learning. Learn Mem. 2016 Apr 15;23(5): 229-37. doi: 10.1101/1m.041004.115.
Key words: motor learning, childhood, memory

2. Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL. Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med. 2016 Apr 6; 8(333):333ra48. doi: 10.1126/scitranslmed.aad0623.
Key words: projection, neurons, neurotoxicity

1. Corbit LH, Fischbach SC, Janak PH. Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of pavlovian-instrumental transfer with alcohol and sucrose rewards. Eur J Neurosci. 2016 Mar 11. doi:10.1111/ejn.13235. [Epub ahead of print]
Key words: nucleus accumbens, alcohol, sucrose, rewards, incentive, learning, motivation, stimulus, ventral striatum

2. de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. Lhx2 is an essential factor for retinal gliogenesis and notch signaling. J Neurosci. 2016 Feb 24;36(8):2391-405. doi:10.1523/JNEUROSCI.3145-15.2016.
Key words: Lhx2; retinal gliogenesis; Müller glia; Notch; differentiation; retina

3. Haith AM, Pakpoor J, Krakauer JW. Independence of movement preparation and movement initiation.
J Neurosci. 2016 Mar 9;36(10):3007-15. doi:10.1523/JNEUROSCI.3245-15.2016.
Key words: preparation, movement, initiation

4. Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL. The nutrient sensor OGT in PVN neurons regulates feeding. Science. 2016 Mar 18;351(6279):1293-6. Doi:10.1126/science.aad5494.
Key words: OGT, PVN, feeding

5. Long AW, Roemmich RT, Bastian A. Blocking trial-by-trial error correction does not interfere with motor learning in human walking. J Neurophysiol 2016 Feb 24:jn.00941.2015. doi:10.1152/jn.00941.2015. [Epub ahead of print]
Key words: motor learning, adaptation, feedback, gait, human walking.

6. Mo A, Luo C, David FP, Mukamel EA, Henry GL, Nery JR, Urich MA, Picard S, Lister R, Eddy SR, Beer MA, Ecker JR, Nathans J. Epigenomic landscapes of retinal rods and cones. Elife. 2016 Mar 7;5. pii:e11613. Doi:10.7554/eLife.11613.
Key words: epigenomic, retinal, rods, cones

7. Statton MA, Toliver A, Bastian AJ. A dual-learning paradigm can simultaneously train multiple characteristics of walking. J Neurophysiol 2016 Mar 9:jn.00090.2016. doi: 10.1152/jn.00090.2016. [Epub ahead of print]
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8. Vaziri S, Connor CE. Representation of gravity-aligned scene structure in ventral pathway visual cortex.
Curr Biol. 2016 Feb 23. pii: S0960-9822(16)00072-5. doi:10.1016/j.cub.2016.01.022.
Key words: gravity-aligned, visual cortex

1. Gu Y, Chiu SL, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D, Huganir RL. Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci USA. 2016 Feb 16;113(7):E922-31. doi: 10.1073/pnas.152726113. Epub 2016 Feb 2.
Key words: vesicular, sorting, receptors

2. Kim J, Matney CJ, Roth RH, Brown SP. Synaptic organization of the neuronal circuits of the claustrum.
J Neurosci. 2016 Jan 20;36(3):773-84. doi: 10.1523/JNEUROSCI.3643-15.2016.
Key words: claustrum

3. Wang H, Ardiles AO, Yang S, Tran T, Posada-Duque R, Valdivia G, Back M, Chuang YA, Palacios AG, Gallagher M, Worley P, Kirkwood A. Metabotropic glutmate receptors induce a form of LTP controlled by translation and arc signaling in the hippocampus. J Neurosci. 2016 Feb 3; 36(5):1723-9. doi: 10.1523/JNEUROSCI.0878-15.2016.
Key words: LTP, translation, arc

4. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P, Song H. Lin28A binds active promoters and recruits Tet1 to regulate gene expression. Mol Cell. 2016 Jan7;61(1):153-60. doi:10.1016/j.molcel.2015.11.020. Epub 2015 Dec 17.
Key words: Lin28A, gene expression

1. Campbell DP, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016 Jan 20; 6:1984. doi: 10.1038/rep19484.
Key words: notch, auditory, development

2. Guha P, Harraz MM, Snyder SH. Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci USA. 2016 Jan 19. pii: 201524860. [Epub ahead of print]
Key words: cocaine, nitric, oxide, GAPDH

3. Harraz MM, Tyagi R, Cortés P, Snyder SH. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic rheb degradation. Mol Psychiatry. 2016 Jan 19. doi:10.1038/mp.2015.211. [Epud ahead of print]
Key words: ketamine, mTOR, Rheb

4. Hu B, Kane-Jackson R, Niebur E. A proto-object based saliency model in three-dimensional space.
Vision Res. 2015 Dec 28. pii: S0042-6989(15)00370-3. doi: 10.1016/j.visres.2015.12.004. [Epub ahead of print]
Key words: object, saliency, space

5. Zhang-Hooks Y, Agarwal A, Mishina M, Bergles DE. NMDA receptors enhance spontaneous activity and promote neuronal survival in the developing cochlea. Neuron. 2016 Jan 6. pii: S0896-6273(15)01118-6. doi:10.1016/j.neuron.2015.12.016. [Epub ahead of print]
Key words: NMDA, receptors, activity, survival, cochlea

1. Chen X, Stuphorn V. Sequential selection of economic good and action in medial frontal cortex of macaques during value-based decisions. Elife. 2015 Nov 27;4. pii: e09418. doi: 10.7554/eLife.09418. [Epub ahead of print]
Key words: macaques, value-based decisions

2. He K, Huertas M, Hong SZ, Tie X, Hell JW, Shouval H, Kirkwood A. Distinct eligibility traces for LTP and LTD in cortical synapses. Neuron. 2015 Nov 4;88(3):528-38. doi: 10.1016/j.neuron.2015.09.037.
Key words: eligibility, traces, LTP, LTD

3. Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief dark exposure reduces tonic inhibition in visual cortex. J Neurosci. 2015 Dec 2;35(48):15916-20. doi:10.1523/JNEUROSCI.1813-15.2015.
Key words: dark, exposure, visual, cortex

4. Therrien AS, Wolpert DM, Bastian AJ. Effective reinforcement learning following cerebellar damage requires a balance between exploration and motor noise. Brain. 2015 Dec 1. pii: awv329. [Epub ahead of print]
Key words: learning, cerebellar damage

5. Wang HC, Lin CC, Cheung R, Zhang-Hooks Y, Agarwal A, Ellis-Davies G, Rock J, Bergles DE. Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells.
Cell. 2015 Dec 3;163(6):1348-59. doi: 10.1016/j.cell.2015.10.070. Epub 2015 Nov 25.
Key words: spontaneous, activity, cochlear, support cells

6. Yang H, Kwon SE, Severson KS, O'Connor DH. Origins of choice-related activity in mouse somatosensory cortex. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4183. [Epub ahead of print]
Key words: choice, somatosensory, cortex

1. Silva D, Feng T, Foster DJ. Trajectory events across hippocampal place cells require previous experience.
Nat Neurosci. 2015 Oct 26. doi:10.1038/nn.4151. [Epub ahead of print]
Key words: trajectory, hippocampal place, experience

2. Statton MA, Encarnacion M, Celnik P, Bastian AJ. A Single bout of moderate aerobic exercise improves motor skill acquisition. PLoS One. 2015 Oct 27;10(10):e0141393. doi: 10.1371/journal.pone.014393. eCollection 2015.
Key words: aerobic exercise, motor skill acquisition

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November 2018 articles:
Trends in Clinical Research Program
Clinical Research Annual Reports
Change in JHM IRB Review Fees for Commercially-Funded Studies
Data and Safety Monitoring Board Training Manual Now Available
Good Clinical Practice (GCP) Fundamentals: Understanding and Applying GCP to Human Subject Research
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Change in Federalwide Assurance [FWA] Numbers
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
NIH Requirement for Single IRB (sIRB)
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Clinical Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Mallinckrodt Scholar Award
National Science Foundation (NSF) Major Research Instrumentation Program (MRI) Instrument Acquisition or Development
Michael J. Fox Foundation (MJFF) Challenge
NIH Loan Repayment Programs - Action required by November 9
Prohibited Mention of Prior Review for New Replacement Applications
NIH Policy on Foreign Component Involvement
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants

This Month's Departmental Listings

Upcoming Deadlines for November, December and January

November Events at the Genetic Resources Core Facility


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