Web notes  

July 2020

Neuroscience Archives

1. Babola TA, Kersbergen CJ, Wang HC, Bergles DE. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. Elife. 2020 Jan 8;9. pii: e52160. doi: 10.7554/eLife.52160. [Epub ahead of print]
Key words: purinergic, cochlear, excitability

2. Day KA, Bastian AJ. Providing low-dimensional feedback of a high-dimensional movement allows for improved performance of a skilled walking task. Sci Rep. 2019 Dec 24;9(1):19814. doi: 10.1038/s41598-019-56319-9.
Key words: performance, skilled, walking

3. Day KA, Cherry-Allen KM, Bastian AJ. Individualized feedback to change multiple gait deficits in chronic stroke. J Neuroeng Rehabil. 2019 Dec 23;16(1):158. doi: 10.1186/s12984-019-0635-4.
Key words: gait, stroke

4. Galasko D, Xiao M, Xu D, Smirnov D, Dewit N, Vanbrabant J, Jacobs D, Vanderstichele H, Vanmechelen E, Alzheimer's Disease Neuroimaging Initiative (ADNI), Worley P. Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease. Alzheimers Dement (N.Y.) 2019;5:871-882.
Key words: CSF, MCI, Alzheimer's

1. Doughtery SE, Kajstura TJ, Jin Y, Chan-Cortés MH, Kota A, Linden DJ. Catecholaminergic axons in the neocortex of adult mice regrow following brain injury. Exp Neurol. 2019 Nov 4;323:113089. doi: 10.1016/j.expneural.2019.113089. [Epub ahead of print].
Key words: Catecholaminergic, axons, brain, injury

2. GoodSmith D, Lee H, Neunuebel JP, Song H, Knierim JJ. Dentate gyrus mossy cells share a role in pattern separation with dentate granule cells and proximal CA3 pyramidal cells. J Neurosci. 2019 Oct 21. pii: 0940-91. doi: 10.1523/JNEUROSCI.0940-19.2019. [Epub ahead of print].
Key words: pattern separation, CA3


3. Kodama T, Gittis A, Shin M, Kelleher K, Kolkman K, McElvain L, Lam M, du Lac S. Graded co-expression of ion channel, neurofilament, and synaptic genes in fast-spiking vestibular nucleus neurons. J Neurosci. 2019 Nov 12. pii: 1500-19. doi: 10.1523/JNEUROSCI.1500-19.2019. [Epub ahead of print].
Key words: neurofilament, spiking vestibular, neurons

4. Tran T, Bridi M, Koh MT, Gallagher M, Kirkwood A. Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input. Neurobiol Aging. 2019 Oct;82:120-127. doi: 10.1016/j.neurobiolaging.2019.07.010. Epub 2019 Jul 23.
Key words: cognitive, aged, rats

5. Vandaele Y, Mahajan NR, Ottenheimer DJ, Richard JM, Mysore SP, Janak PH. Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training. Elife. 2019 Oct 17;8. pii: e49536. doi: 10.7554/eLife.49536.
Key words: recruitment, dorsolateral striatum, training


6. Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Bilirubin links heme metabolism to neuroprotection by scavenging superoxide. Cell Chem Biol. 2019 Oct 17;26(10):1450-1460.e7. doi: 10.1016/j.chembiol.2019.07.006. Epub 2019 Jul 25.
Key words: bilirubin, neuroprotection

1. Afify A, Betz JF, Riabinina O, Lahondère C, Potter CJ. Commonly used insect repellents hide human odors from anopheles mosquitoes. Curr Biol. 2019 Oct 15. pii: S0960-9822(19)31167-4. doi: 10.1016/j.cub.2019.09.007. [Epub ahead of print].
Key words: insect, repellents, odors, anopheles

2. Britson KA, Black AD, Wagner KR, Lloyd TE. Performing human skeletal muscle xenografts in immunodeficient mice. J Vis Exp. 2019 Sep 16;(151). doi: 10.3791/59966.
Key words: human, muscle, xenografts, mice

3. Chokshi V, Gao M, Grier BD, Owens A, Wang H, Worley PF, Lee HK. Input-specific metaplasticity in the visual cortex requires Homer1a-mediated mGluR5 signaling. Neuron 2019 Sep 5. S0896-6273(19)30701-9. doi: 10.1016/j.neuron.2019.08.017. [Epub ahead of print].
Key words: metaplasticity, visual, homer1a, mGluR5

4. Ehmsen JT, Kawaguchi R, Mi R, Coppola G, Höke A. Longitudinal RNA-Seq analysis of acute and chronic neurogenic skeletal muscle atrophy. Sci Data. 2019 Sep 24;6(1):179. doi: 10.1038/s41597-019-0185-4.
Key words: RNA-Seq, skeletal, muscle, atrophy

5. Frandolig JE, Matney CJ, Lee K, Kim J, Chevée M, Kim SJ, Bickert AA, Brown S3. The synaptic organization of layer 6 circuits reveals inhibition as a major output of a neocortical sublamina. Cell Rep. 2019 Sep 17;28(12):3131-3143.e5. doi: 10.1016/j.celrep.2019.08.048.
Key words: inhibition, neocortical, sublamina

6. Ramos DM, d'Ydewalle C, Gabetta V, Dakka A, Klein SK, Norris DA, Matson J, Taylor SJ, Zaworski PG, Prior TW, Snyder PJ, Valdivia D, Hatem CL, Waters I, Gupte N, Swoboda KJ, Rigo F, Bennett CF, Naryshkin N, Paushkin S, Crawford TO, Sumner CJ. Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. J Clin Invest. 2019 Oct 7. pii: 123120. doi: 10.1172/JC1124120. [Epub ahead of print].
Key words: age, SMN, treatment

7. Xie X, Tabuchi M, Corver A, Duan G, Wu MN, Kolodkin AL. Semaphorin 2b regulates sleep-circuit formation in the Drosophila central brain. Neuron 2019 Sep 26. pii: S0896-6273(19)30645-2. doi: 10.1016/j.neuron.2019.07.019. [Epub ahead of print].
Key words: semaphorin 2b, sleep-circuit, drosophila

1. Donde A1,2, Sun M1, Ling JP1,2, Braunstein KE1, Pang B1, Wen X1, Cheng X1, Chen L3, Wong PC4,5. Splicing Repression in a Major Function of TDP-43 in Motor Neurons.
Acta Neuropathol 2019 Jul 22. doi: 10.1007/s00401-019-02042-8. [Epub ahead of print].
Key words: splicing, repression, TED-43, neurons

2. Dunn-Weiss E1,2, Nummela SU1,2, Lempel AA1,2, Law J2, Ledley J2, Salvino P2, Nielsen KJ3,2. Visual Motion and Form Integration in the Behaving Ferret.
eNeuro 2019 Aug 1. pii: ENEURO.0228-19.2019. doi: 10.1523/ENEURO.0228-19.2019. [Epub ahead of print].
Key words: visual, motion, ferret

3. Rattner A1, Williams J1,2, Nathans J1,2,3,4. Roles of HIFs and VEGF in Angiogenesis in the Retina and Brain.
J Clin Invest 2019 Aug 12;130. pii:126655. doi: 10.1172/JC1126655. eCollection 2019 Aug 12.
Key words: HIFs, VEGF, angiogenesis, retina, brain

4. Rodriguez G1, Mesik L2,3, Gao M2, Parkins S1, Saha R2, Lee HK4,2,3. Disruption of NMDA Receptor Function Prevents Normal Experience-dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex.
J Neurosci 2019 Aug 14. pii: 2117-18. doi: 10.1523/JNEUROSCI.2117-18.2019. [Epub ahead of print].
Key words: NMDA, homeostatic, synaptic, plasticity, visual

5. Vasavda C1, Kothari R1, Malla AP1, Tokhunts R2, Lin A3, Ji M4, Ricco C1, Xu R5, Saavedra HG6, Sbodio JI1, Snowman AM1, Albacarys L1, Hester L1, Sedlak TW7, Paul BD8, Snyder SH9. Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.
Cell Chem Biol 2019 Jul 23. pii: S2451-9456(19)30218-1. doi: 10.1016/j.chembiol. 2019.07.006.
Key words: bilirubin, heme, neuroprotection

6. Yin X, Xu JC, Cho GS, Kwon C, Dawson TM, Dawson VL. Neurons derived from human induced pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities. eNeuro, 2019 Aug 14. pii: ENEURO.0148-19.2019. doi: 1523/ENEURO.0148-19.2019. [Epub ahead of print].
Key words: human, induced, pluripotent, stem, cells, brain, circuits

1. Fraser KM, Janak PH. Occasion setters attain incentive motivational value: implications for contextual influences on reward-seeking. Learn Mem. 2019 Jul 15;26(8):291-298. doi: 10.1101/lm.049320.119. Print 2019 Aug.
Key words: occasion, setters, reward

2. Mi R, Tammia M, Shinn D, Li Y, Martin R, Mao HQ, Höke A. Oligodendrocyte precursors gain Schwann cell-like phenotype and remyelinate axons upon engraftment into peripheral nerves. J Tissue Eng Regen Med. 2019 Jul 15. doi: 10.1002/term.2935. [Epub ahead of print].
Key words: oligodendrocyte, remyelinate, peripheral


3. Peng X, Williams J, Smallwood PM, Nathans J. Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. PLoS One. 2019 Jul 18;14(7): e0219384. doi: 10.1371/journal.pone.0219384. eCollection 2019.
Key words: binding, APP, CNTN3

4. Pilato CM, Park HJ, Kong L, d'Ydewalle C, Valdivia D, Chen KS, Griswold-Prenner I, Sumner CJ. Motor neuron loss in SMA is not associated with somal stress-activated JNK/c-Jun Signaling. Hum Mol Genet. 2019 Jul 4. pii: ddz150. doi: 10.1093/hmg/ddz150. [Epub ahead of print].
Key words: neuron, loss, SMA, JNK

5. Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong X, Wu X, Zhang Y, Snyder SH, Gaudenzio N, Vidal JE, Dong X. A connective tissue mast-cell-specific receptor detects bacterial quorum-sensing molecules and mediates antibacterial immunity. Cell Host Microbe. 2019 Jul 10;26(1):114-122.e8. doi: 10.1016/j.chom.2019.06.003.
Key words: mast, antibacterial, immunity

1. Clark BS, Stein-O'Brien GL, Shiau F, Cannon GH, Davis-Marcisak E, Sherman T, Santiago CP, Hoang TV, Rajaii F, James-Esposito RE, Gronostajski RM, Fertig EJ, Goff LA, Blackshaw S. Single-cell RNA-Seq analysis of retinal development identifies NFI Factors as regulating mitotic exit and late-born cell specification.
Neuron. 2019 Jun 19;102(6):1111-1126.e5. doi: 10.1016/j.neuron.2019.04.010. Epub 2019 May 22.
Key words: retinal, NFI factors, cell specification


2. Hu B, von der Heydt R, Niebur E. Figure-ground organization in natural scenes: performance of a recurrent neural model compared with neurons of area V2. eNeuro. 2019 June 5. pii: ENEURO.0479-18.2019. doi: 10.1523/ENEURO.0479-18.2019. [Epub ahead of print].
Key words: figure-ground, neural model, V2

3. Prajapati-DiNubila M, Benito-Gonzalez A, Golden EJ, Zhang S, Doetzlhofer A. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.
Elife. 2019 Jun 12;8. pii: e47613. doi: 10.7554/eLife.47613.
Key words: Activin, follistatin, cochlea

4. Zhang W, Chuang YA, Na Y, Ye Z, Yang L, Lin R, Zhou J, Wu J, Qiu J, Savonenko A, Leahy DJ, Huganir R, Linden DJ, Worley PF. Arc oligomerization is regulated by CaMKII phosphorylation of the GAG domain: an essential mechanism for plasticity and memory formation. Mol Cell. 2019 May 23. pii: S1097-2765(19)30357-0. doi:10.1016/j.molcel.2019.05.004.. [Epub ahead of print].
Key words: Arc; CAMKII; capsid; evolution; learning and memory; phosphorylation; polymerization; synapse plasticity

1. Cho C, Wang Y, Smallwood PM, Williams J, Nathans J. Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. Elife. 2019 May 8;8. pii: e45542. doi: 10.7554/eLife.45542.
Key words: blood-brain barrier; blood-retina barrier; canonical Wnt signaling; developmental biology; genetics; genomics; mouse; mouse genetics; retinal angiogenesis; vascular endothelial cells

2. Faria AV, Crawford J, Ye C, Hsu J, Kenkare A, Schretlen D, Sawa A. Relationship between
neuropsychological behavior and brain white matter in first-episode psychosis.
Schizophr Res. 2019 Apr 13. pii: S0920-9964(19)30135-5. doi: 10.1016/j.schres.2019.04.010.
Key words: neuropsychological, white, matter, psychosis

3. Fischback-Weiss S1, Janak P2. Decreases in cued reward seeking after reward-paired inhibition of mesolimbic dopamine. Neuroscience. 2019 Apr 25. pii: S0306-4522(19)30284-2. doi:10.1016/j.neuroscience.2019.04.035. [Epub ahead of print].
Key words: reward, seeking, dopamine

4. Guha P, Snyder SH. Noncatalytic functions of IPMK are essential for activation of autophagy and liver regeneration. Autophagy. 2019 May 8:1-2. doi: 10.1080/15548627.2019.1615305. [Epub ahead of print].
Key words: IPMK, autophagy, liver, regeneration

5. Heng JS, Rattner A, Stein-O'Brien GL, Winer BL, Jones BW, Vernon HJ, Goff LA, Nathans J. Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9103-9114. doi: 10.1073/pnas.1821122116. Epub 2019 Apr 15.
Key words: Norrin, retina, hypoxic, single, cell

6. Jeck DM, Qin M, Egeth H, Niebur E. Unique objects attract attention even when faint.
Vision Res. 2019 Apr 29. pii: S0042-6989(19)30088-4. doi: 10.1016/j.visres.2019.04.004. [Epub ahead of print].
Key words: objects, attention, faint

7. John J, Thirunavukkarasu P, Ishizuka K, Parekh P, Sawa A. An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration.
PJ Syst Biol Appl. 2019 May 7;5:17. doi: 10.1038/s41540-019-0094-3. eCollection 2019.
Key words: in-silico, DISC1, interactome

8. Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X4. Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch. Immunity. 2019 Apr 23. pii: S1074-7613(19)30130-X. doi: 10.1016/j.immuni.2019.03.013. [Epub ahead of print].
Key words: G, protein, non-histaminergic, itch

9. Meixiong J, Vasavda C, Snyder SH, Dong X. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. Proc Natl Acad Sci U S A. 2019 May 8. pii: 201903316. doi:10.1073/pnas.1903316116. [Epub ahead of print].
Key words: MRGPRX4, cholestatic, pruritus

10. Wang Y, Sabbagh MF, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. Elife. 2019 Apr 1;8. pii: e43257. doi: 10.7554/eLife.43257.
Key words: beta, catenin, ocular, vasculatures

11. Ye Z, Cudmore RH, Linden DJ. Estrogen-dependent functional spine dynamics in neocortical pyramidal neurons of the mouse. J.Neurosci. 2019 Apr 16. pii: 2772-18. doi: 10.1523/JNEUROSCI.2772-18.2019. [Epub ahead of print].
Key words: estrogen, dependent, spine, mouse

12. Younes L, Albert M, Moghekar A, Soldan A, Pettigrew C, Miller MI. Identifying changepoints in biomarkers during the preclinical phase of Alzheimer's Disease. Front Aging Neurosci. 2019 Apr 2;11:74. doi: 10. 10.3389/fnagi.2019.00074. eCollection 2019.

13. Zibetti C, Liu S, Wan J, Qian J, Blackshaw S. Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin. Commun Biol. 2019 Apr 25;2:142. doi: 10.1038/s42003-019-0375-9. eCollection 2019.

1. Chikshi V, Druciak B, Worley PF, Lee HK. Homer1A is required for establishment of contralateral bias and maintenance of ocular dominance in mouse visual cortex. J. Neurosci. 2019 Mar 13. pii: 3188-18. doi: 10.1523/JNEUROSCI.3188-18.2019. [Epub ahead of print].
Key words: Homer1a, ocular, dominance

2. Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019 May;22(5):741-752.
Key words: astroglia, Norrin

3. Nardou R, Lewis EM, Rothhaas R, Xu R, Yang A, Boyden E, Dölen G. Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1075-9. [Epub ahead of print].
Key words: critical, period, MDMA

4. Vyas P, Wu JS, Jimenez A, Glowatzki E, Fuchs PA. Characterization of transgenic mouse lines for labeling Type I and Type II afferent neurons in the cochlea. Sci Rep. 2019 Apr 3;9(1):5549. doi: 10.1038/s41598-019-41770-5.
Key words: type I, type II, neurons, cochlea

5. Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH. Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis.
Proc Natl Acad Sci USA. 2019 Apr 9;116(15):7471-7476. doi: 10.1073/pnas.1820245116.
Key words: H2AX, mitochondrial, homeostasis

6. Yoo S, Cha D, Kim DW, Hoang TV, Blackshaw S. Tanycyte-Independent control of hypothalamic leptin signaling. Front Neurosci. 2019 Mar 19;13:240. doi: 10.3389/fnins.2019.00240. eCollection 2019.
Key words: tanycyte, leptin, signaling

1. Fernandes D, Santos SD, Coutinho E, Whitt JL, Beltrão N, Rondão T, Leite MI, Buckley C, Lee HK, Carvalho AL. Disrupted AMPA receptor function upon genetic- or antibody-mediated loss of autism-associated CASPR2. Cereb Cortex. 2019 Mar 4. pii: bhz032. doi: 10.1093/cercor/bhz032. [Epub ahead of print].
Key words: AMPA, autism, CASPR2

2. Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, Resnick AC, Snyder SH. IPMK mediates activation of ULK signaling and transcriptional regulation of autophagy linked to liver inflammation and regeneration.
Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. doi: 10.1016/j.celrep.2019.02.013.
Key words: IPMK, autophagy, liver, regeneration

3. Kulason S, Tward DJ, Brown T, Sicat CS, Liu CF, Ratnanather JT, Younes L, Bakker A, Gallagher M, Albert M, Miller MI; Alzheimer's Disease Neuroimaging Initiative. Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment. Neuroimage Clin. 2019;21:101617. doi: 10.1016/j.nicl.2018.101617. Epub 2018 Dec 5.
Key words: cortical, thickness, cognitive, impairment

4. Park J, Longo F, Park SJ, Lee S, Bae M, Tyagi R, Han JH, Kim S, Santini E, Klann E, Snyder SH. Inositol polyphosphate multikinase mediates extinction of fear memory. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2707-2712. doi: 10.1073/pnas.1812771116.
Key words: inositol, polyphosphate, multikinase, memory

5. Severson KS, Xu D, Yang H, O'Connor DH. Coding of whisker motion across the mouse face. Elife. 2019 Feb 28;8. pii: e41535.
Key words: coding, whisker, mouse

6. Xu Q, Dong X. Calcium imaging approaches in investigation of pain mechanism in the spinal cord.
Exp Neurol. 2019 Mar 7. pii: S0014-4886(19)30039-1. doi: 10.1016/j.expneurol.2019.03.002.
Key words: calcium imaging, spinal cord

7. Yue WWS, Silverman D, Ren X, Frederiksen R, Sakai K, Yamashita T, Shichida Y, Cornwall MC, Chen J, Yau KW. Elementary response triggered by transducin in retinal rods.
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5144-5153. https://www.ncbi.nlm.nih.gov/pubmed/30796193

1. Andzelm MM, Vanness D, Greenberg ME, Linden DJ. A late phase of long-term synaptic depression in cerebellar Purkinje cells requires activation of MEF2. Cell Rep. 2019 Jan 29;26(5):1089-1097. doi: 10.1016/j.celrep.2019.01.004.
Key words: late phase, synaptic depression, MEF2

2. Green DP, Limjunyawong N, Gour N, Pundir P, Dong X. A mast-cell-specific receptor mediates neurogenic inflammation and pain. Neuron. 2019 Feb 6;101(3):412-420.e3. doi: 10.1016/j.neuron.2019.01.012. Epub 2019 Jan 24.
Key words: mast-cell-specific receptor, inflammation, pain

3. Jayakumar RP, Madhav MS, Savelli F, Blair HT, Cowan NJ, Knierim JJ. Recalibration of path integration in hippocampal place cells. Nature 2019 Feb 11. doi: 10.1038/s41586-019-0939-3. [Epub ahead of print].
Key words: path integration, place cells

4. Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A. The glutathione cycle shapes synaptic glutamate activity. Proc Natl Acad Sci USA. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116.
Key words: glutathione, synaptic, activity

1. Keiflin R, Pribut HJ, Shah NB, Janak PH. Ventral tegmental dopamine neurons participate in reward identity predictions. Curr Biol. 2019 Jan 7;29(1):93-103.e3. doi: 10.1016/j.cub.2018.11.050. Epub 2018 Dec 20.
Key words: dopamine, neurons, reward, identity

2. Lee BC, Tward DJ, Mitra PP, Miller MI. On variational solutions for whole brain serial-section histology using a Sobolev prior in the computational anatomy random orbit model. PLoS Comput Biol. 2018 Dec 26;14(12):e1006610. doi: 10.1371/journal.pcbi.1006610. eCollection 2018 Dec.
Key words: computational, anatomy, random, orbit

3. Lempel AA, Nielsen KJ. Ferrets as a model for higher-level visual motion processing.
Curr Biol. 2018 Dec 10. pii:S0960-9822(18)31483-0. doi: 10.1016/j.cub.2018.11.017. [Epub ahead of print].
Key words: ferrets, motion processing

4. Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL. Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. J Comp Neurol. 2019 Jan 1;527(1):282-296. doi: 10.1002/cne.24507. Epub 2018 Nov 11.
Key words: accessory, optic, system, Sema6A

5. Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH1 Dong X. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife. 2019 Jan 18;8.pii:e44116. doi: 10.7554/eLife.44116. [Epub ahead of print].
Key words: bilirubin, receptor, cholestatic, itch

6. Shah AP, Johnson MD, Fu X, Boersma GJ, Shah M, Wolfgang MJ, Tamashiro KL, Baraban JM. Deletion of Translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.
Int J Obes (Lond). 2019 Jan 15. doi: 10.1038/s41366-018-0315-7. [Epub ahead of print].
Key words: translin, glucose, tolerance

7. Spagnolo PA, Gómez Pérez LJ, Terraneo A, Gallimberti L, Bonci A. Neural correlates of cue- and stress-induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions.
Eur J Neurosci. 2018 Dec 21. doi: 10.1111/ejn.14313. [Epub ahead of print].
Key words: gambling, disorders, transcranial, magnetic, stimulation

8. Wang Y, Cho C, Williams J, Smallwood PM, Zhang C, Junge HJ, Nathans J. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci USA. 2018 Dec 11;115(50):E11827-E11836. doi: 10.1073/pnas.1813217115. Epub 2018 Nov 26.
Key words: Norrin, Wnt7A, Wnt7b, blood, brain, barrier, maintenance

1. Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Plenikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. Poly(ADP-ribose) drives pathologic ?-synuclein
neurodegeneration in Parkinson's Disease. Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.
Key words: ?-synuclein neurodegeneration, Parkinson's disease

2. Miller SJ, Glatzer JC, Hsieh YC, Rothstein JD. Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model. J Neurogenet. 2018 Nov 6:1-14. doi: 10.1080/01677063.2018.1513408. [Epub ahead of print].
Key words: cortical astroglia, G93A SOD1 ALS

3. Peng X, Emiliani F, Smallwood PM, Rattner A, Lei H1, Sabbagh MF, Nathans J. Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions.
Elife. 2018 Oct 22;7. pii: e40982. doi: 10.7554/eLife.40982.
Key words: affinity capture, RNAseq (ACAPseq)

4. Shen H, Marino RAM, McDevitt RA, Bi GH, Chen K, Madeo G, Lee PT, Liang Y, De Biase LM, Su TP, Xi ZX, Bonci A. Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.Proc Natl Acad Sci USA. 2018 Nov 15. pii: 201800886. doi: 10.1073/pnas.1800886115. [Epub ahead of print]
Key words: MPTP, neurotoxicity

5. Tang X, Ross CA, Johnson H3 Paulsen JS, Younes L, Albin RL, Ratnanather JT, Miller MI. Regional subcortical shape analysis in premanifest Huntington's disease. Hum Brain Mapp. 2018 Oct 30. doi: 10.1002/hbm.24456. [Epub ahead of print].
Key words: subcortical, shape, Huntington's

1. Edsinger E, Dölen G. A conserved role for serotonergic neurotransmission in mediating social behavior in octopus. Curr Biol 2018 Oct 8; 28(19):3136-3142.e4. doi: 10.1016/j.cub.2018.07.061. Epub 2018 Sep 20.
Key words: serotonergic, behavior, octopus

2. Jiang Z, Yu WWS, Chen L, Sheng Y, Yau KW. Cyclic-nucleotide- and HCN-channel-mediated phototransduction in intrinsically photosensitive retinal ganglion cells.
Cell. 2018 Oct 18;175(3):652-664.e12.
Key words: HCN, phototransduction, retinal ganglion cells

3. Ottenheimer D, Richard JM, Janak PH. Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens. Nat. Commun. 2018 Oct 19;9(1):4350. doi: 10.1038/s41467-018-06849-z.
Key words: pallidum, value, accumbens

4. Rodriguez G, Chakraborty D, Schrode KM, Saha R, Uribe I, Lauer AM, Lee HK. Cross-modal reinstatement of thalamocortical plasticity accelerates ocular dominance plasticity in adult mice. Cell Rep. 2018 Sep 25;24(13):3433-3440.e4. doi: 10.1016/j.celrep.2018.08.072.
Key words: cross-modal reinstatement, ocular, plasticity

5. Tabuchi M, Monaco JD, Duan G, Bell B, Liu S, Liu Q, Zhang K, Wu MN. Clock-generated temporal codes determine synaptic plasticity to control sleep.Ce ll. 2018 Sep 27. pii:S0092-8674(18)31228-5. doi: 10.1016/j.cell.2018.09.016. [Epub ahead of print].
Key words: temporal codes, plasticity, sleep

1. Leech KA, Day KA, Roemmich RT, Bastian AJ. Movement and perception recalibrate differently across multiple days of locomotor learning. J Neurophysiol 2018 Sep 5. doi: 10.1152/jn.00355.2018. [Epub ahead of print].
Key words: locomotor, learning

2. Li Q, Qian C, Zhou FQ. Investigating mammalian axon regeneration: in vivo electroporation of adult mouse dorsal root ganglion. J Vis Exp. 2018 Sep 1;(139).
Key words: vivo, electroporation, mouse, ganglion

3. Sabbagh MF, Heng JS, Luo C, Castanon RG, Nery JR, Rattner A, Goff LA, Ecker JR, Nathans J. Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. Elife. 2018 Sep 6;7. pii: e36187.
Key words: transcriptional, epigenomic, landscapes, endothelial

4. Wang XW, Li Q, Liu CM, Hall PA, Jiang JJ, Katchis CD, Kang S, Dong BC, Li S, Zhou FQ. Lin28 signaling supports mammalian PNS and CNS axon regeneration. Cell Rep. 2018 Sep 4;24(10):2540-2552.e6.
Key words: Lin28, mammalian, regeneration

1. Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic control of spontaneous activity in the developing auditory system. Neuron. 2018 Aug 8;99(3):511-524.e5. doi: 10.1016/j.neuron.2018.07.004. Epub 2018 Aug 1.
Key words: homeostatic, spontaneous, activity, auditory

2. Cherry-Allen KM, Statton MA, Celnik PA, Bastian AJ. A dual-learning paradigm simultaneously improves multiple features of gait post-stroke. Neurorehabil Neural Repair, 2018 Aug 7;1545968318792623. doi:10.1177/1545968318792623. [Epub ahead of print].
Key words: gait post-stroke

3. Chin SG, Maguire SE, Huoviala P, Jefferis GSXE, Potter CJ. Olfactory neurons and brain centers directing oviposition decisions in drosophila. Cell Rep. 2018 Aug 7;24(6):1667-1678. doi: 10.1016/j.celrep.2018.07.018.
Key words: olfactory, oviposition

4. Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL. Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. J Comp Neurol. 2018 Aug 3. doi: 10.1002./cne.24507. [Epub ahead of print].
Key words: accessory, optic, system, Sema6A

5. Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S. Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.
Dev Biol. 2018 Jul 29. pii: S0012-1606(18)30451-2. doi: 10.1016/j.ydbio.2018.07.021. [Epub ahead of print].
Key words: Wnt, nucleogenesis, hypothalamus

6. Saunders BT1,2,3, Richard JM4,5,6, Margolis EB7, Janak PH8,9,10. Dopamine Neurons Create Pavlovian Conditioned Stimuli with Circuit-defined Motivational Properties.
Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.
Key words: dopamine, Pavlovian, motivational

7. Sun S, Babola T, Pregernig G, So KS, Nguyen M, Su SM, Palermo AT, Bergles DE, Burns JC, Müller U. Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. Cell. 2018 Jul 30. pii: S0092-8674(18)30902-4. doi: 10.1016/j.cell2018.07.008. [Epub ahead of print].
Key words: hair, cell, mechanotransduction, activity

8. Therrien AS, Wolpert DM, Bastian AJ. Increasing motor noise impairs reinforcement learning in healthy individuals. eNeuro. 2018 Aug 13;5(3). pii: ENEURO.0050-18.2018. doi: 10.1523/ENEURO.0050-18.2018.
Key words: motor noise, reinforcement learning

9. Xin W, Schuebel KE, Jair KW, Cimbro R, De Biase LM, Goldman D, Bonci A. Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling.
Neuropsychopharmacology. 2018 Jul 13. doi: 10.1038/s41386-018-0151-4. [Epub ahead of print].
Key words: midbrain, astrocytes, dopamine

10. Zimmet AM, Cowan NJ, Bastian AJ. Patients with cerebellar ataxia do not benefit from limb weights.
Cerebellum. 2018 Aug 1. doi: 10.1007/s12311-018-0962-1. [Epub ahead of print].
Key words: Cerebellar Ataxia, limb weights

1. Nagpal L, Fu C, Snyder SH. Inositol hexakisphosphate kinase-2 in cerebellar granule cells regulates Purkinje-cells and motor coordination via protein 4.1N. J Neurosci. 2018 Jul 13. pii: 1165-18. doi: 10.1523/JNEUROSCI.1165-18.2018. [Epub ahead of print].
Key words: inositol hexakisphosphate kinase-2, Purkinje

2. Tran T, Gallagher M, Kirkwood A. Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats. Neurobiol Aging. 2018 Jun 12;70:92-101. doi: 10.1016/j.neurobiolaging.2018.06.008. [Epub ahead of print].
Key words: postsynaptic inhibitory strength, rats

3. Wu D, Faria AV, Younes L, Ross CA, Mori S, Miller MI. Whole-brain segmentation and change-point analysis of anatomical brain MRI-application in premanifest Huntington's Disease. J Vis Exp. 2018 Jun 9;(136). doi: 10.3791/57256.
Key words: anatomical, MRI, Huntington's

1. Kisner A, Slocomb JE, Sarsfield S, Zuccoli ML, Siemian J, Gupta JF, Kumar A, Aponte Y. Electrophysiological properties and projections of lateral hypothalamic parvalbumin positive neurons.
PLoS One. 2018 Jun 12;13(6):e0198991. doi: 1371/journal.pone.0198991. eCollection 2018.
Key words: lateral hypothalamic, neurons

2. Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH. A Non-canonical feedback circuit for rapid interactions between somatosensory cortices. Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.
Key words: feedback, circuit, somatosensory

3. Tang X, Luo Y, Chen Z, Huang N, Johnson HJ, Paulsen JS, Miller MI. A fully-automated subcortical and ventricular shape generation pipeline preserving smoothness and anatomical topology.
Front Neurosci. 2018 May 17;12:321. doi: 10.3389/fnins.2018.00321. eCollection 2018.
Key words: subcortical ventrical, shape, generation, pipeline

1. Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A. Two distinct mechanisms of experience-dependent homeostasis.
Nat Neurosci. 2018 May 14. doi: 10.1038/s41593-018-0150-0. [Epub ahead of print].
Key words: experience-dependent, homeostasis

2. Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH. Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1. Sci Rep. 2018 May 4;8(1):7039. doi: 10.1038/s41598-018-25468-8.
Key words: germ cell, Sertoli, inositol hexakisphosphate


3. Li RC, Lin CC, Ren X, Wu JS, Molday LL, Molday RS, Yau KW. Ca2+-activated C1 current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci USA. 2018 May 7. pii: 201803443. doi: 10.1073/pnas.1803443115. [Epub ahead of print].
Key words: C1 current, olfactory receptor neurons

4. Ramos-López P, Irizarry J, Pino I, Blackshaw S. Antibody specificity profiling using protein microarrays.
Methods Mol Biol. 2018;1785:223-229. doi: 10.1007/978-1-4939-7841-1_14.
Key words: antibody, profiling

1. Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [epub ahead of print].
Key words: locomotor, learning

2. de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S. Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina. Development. 2018 Apr 12. pii: dev. 159970. doi: 10.1242/dev.159970. [Epub ahead of print}.
Key words: Lhx2, balance, neurogenesis, gliogenesis, retina

3. Dresselhaus EC, Boersma MCH, Meffert M. Targeting of NF-?B to dendritic spines in required for synaptic signaling and spine development. J Neurosci. 2018 Mar 19; pii: 266-16. doi: 10.1523/JNEUROSCI.2663-16.2018. [Epub ahead of print].
Key words: NF-?B

4. Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandy A, Huganir RL. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci USA 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.

5. Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 Mar 19. doi: 10.1038/s41593-018-0121-5. [Epub ahead of print].
Key words: myelin, remodeling, oligodendrogenesis, cortex

6. Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018 Mar 29. pii: eaan4665. doi: 10.1126/science.aan4665. [Epub ahead of print].
Key words: dimethyl fumarate, GAPDH, immunity

7. Larson VA, Mironova Y, Vanderpool KG, Waisman A, Rash JE, Agarwal A, Bergles DE. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. Elife. 2018 Mar 29;7. pii: e34829. doi: 10.7554/eLife.34829.
Key words: oligodendrocytes, potassium, seizure

8. Machamer JB, Woolums BM, Fuller GG, Lloyd TE. FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons. Brain Res. 2018 Apr 3. pii: S0006-8993(18)30180-X. doi: 10.1016/j.brainres.2018.03.037. [Epub ahead of print].
Key words: FUS, synaptic, hyperexcitability

9. Newman EA, Kim DW, Wan J, Wang J, Qian J, Blackshaw S. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Apr 18. pii: S00012-1606(17)30906-5. doi: 10.1016/j.ydbio.2018.04.012. [Epub ahead of print].
Key words: Foxd1, hypothalamic, subtypes

10. Richard JM, Stout N, Acs D, Janak PH. Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure. Elife. 2018 Mar 22;7. pii: e33107. doi: 10.7554/eLife.33107.
Key words: reward, seeking, behavior

11. Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S. A Toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods. 2018 Mar 19. doi: 10.1038/nmeth.4632. [Epub ahead of print]
Key words: immunoprecipitation, grade, monoclonal, human, transcription

12. Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018 Apr 18;9(1):1526. doi:10.1038/s41467-108-03948-9.
Key words: neurobehavioral, redox,homeostasis

13. Xie T, Ho MCW, Liu Q, Horiuchi W, Lin CC, Task D, Luan H, White BH, Potter CJ, WU M. A genetic toolkit for dissecting dopamine circuit function in Drosophila. Cell Rep. 2018 Apr 10;23(2):652-665. doi: 10.1016/j.celrep.2018.03.68.
Key words: genetic toolkit, dopamine, Drosophila

14. Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress granule assembly disrupts nucleocytoplasmic transport. Cell. 2018 Apr 2. pii: S0092-8674 (18)30305-2. doi: 10.1016/j.cell.2018.03.025. [Epub ahead of print].
Key words: stress, granule, nucleocytoplasmic

1. Chung T, Tian Y, Walston J, Hoke A. Increased single fiber jitter level is associated with reduction in motor function with aging. Am J Phys Med Rehabil. 2018 Mar 1. doi: 10.1097/PHM.0000000000000915. [Epub ahead of print].
Key words: single, fiber, jitter

2. Day KA, Leech KA, Roemmich RT, Bastian AJ. Accelerating locomotor savings in learning: compressing four training days to one. J Neurophysiol. 2018 Mar 14. doi: 10.1152/jn.00903.2017. [Epub ahead of print].
Key words: locomotor, training

3. Oldach LM, Gorshkov K, Mills WT 4th, Zhang J, Meffert MK. A biosensor for MAPK-dependent Lin28 signaling. Mol Biol Cell. 2018 Mar 14. pii: mbc.E17-08-0500. doi: 10.1091/mbc.E17-08-0500. [Epub ahead of print].
Key words: MAPK, Lin28

4. Posporelis S, Coughlin JM, Marsman A, Pradhan S, Tanaka T, Wang H, Varvaris M, Ward R, Higgs C, Edwards JA, Ford CN, Kim PK, Lloyd AM, Edden RAE, Schretlen DJ, Cascella NG, Barker PB, Sawa A. Decoupling of brain temperature and glutamate in recent onset of schizophrenia: A 7T proton magnetic resonance spectroscopy study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Mar;3(3):248-254. doi: 10.1016/j.bpsc.2017.04.003. Epub 2017 21.
Key words: schizophrenia, glutamate, brain temperature, magnetic resonance spectroscopy

1. Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to brochoconstriction and airway hyper-responsiveness. Nat Neurosci. 2018 Feb 5. doi: 10.1038/s41593-018-0074-8. [Epub ahead of print].
Key words: mrgprs, bronchoconstriction, airway

2. Sasikumar D, Emeric E, Stuphorn V, Connor CE. First-pass processing of value cues in the ventral visual pathway. Curr Biol. 2018 Feb 19;28(4):538-548.e3. doi: 10.1016/j.cub.2018.01.051. Epub 2018 Feb 8.
Key words: processing, cues, visual, pathway

1. Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA. Variation in activity state, axonal projection, and position define the transcriptional identity of individual neocortical projection neurons.
Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.
Key words: transcriptional, individual, necortical, projection

2. Fischbach-Weiss S, Reese RM, Janak PH. Inhibiting mesolimbic dopamine neurons reduces the initiation and maintenance of instrumental responding. Neuroscience 2017 Dec 15. pii: S0306-4522(17)30874-6. doi: 10.1016/j.neuroscience.2017.12.003. [Epub ahead of print].
Key words: dopamine, instrumental, responding

3. Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1? degradation. Circ Res. 2017 Dec 26. pii: CIRCRESAHA. 117.311983. doi: 10.1161/CIRCRESAHA.117.311983. [Epub ahead of print].
Key words: inositol, multikinase, angiogenesis, HIF


4. Leech KA, Roemmich RT, Bastian AJ. Creating flexible motor memories in human walking. Sci Rep. 2018 Jan 8;8(1):94. doi: 10.1038/s41598-017-18538-w.
Key words: motor, memories, walking

5. Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley P. FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis. Hum Mol Genet. 2017 Dec 18. doi: 10.1093/hmg/ddx426. [Epub ahead of print].
Key words: FRMPD4, intellectual, disability, spine

1. de Melo J, Blackshaw S. In vivo electroporation of developing mouse retina. Methods Mol Biol. 2018;1715:101-111. doi: 1007/978-1-4939-7522-8_8.
Key words: electroporation, retina

2. Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder S. TRPV1 is a physiological regulator of ?-opioid receptors. Proc Natl Acad Sci USA. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print].
Key words: TRPV1, opiod, receptors

1. Hu B, Niebur E. A Recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Dec;43(3):227-243. doi: 10.1007/s10827-017-0659-3. Epub 2017 Sep 19.
Key words: neural, model, contour, integration

2. Tward DJ, Miller MI. On the complexity of human neuroanatomy at the millimeter morphome scale: developing codes and characterizing entropy indexed to spatial scale. Front Neurosci. 2017 Oct 18;11:577. doi: 10.3389/fnins.2017.00577. eCollection 2017.
Key words: human neuroanatomy, entropy indexed

3. Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron. 2017 Nov 14. pii: S0896-6273(17)31021-8. doi: 10.1016/j.neuron.2017.10.029. [Epub ahead of print]
Key words: homeostatic, scaling, cortical, neurons

4. WU JS, Vyas P, Glowatzki E, Fuchs PA. Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrp?) and tyrosine hydroxylas (Th) in Type II afferent neurons of the mouse cochlea. J Comp Neurol. 2017 Oct 21. doi: 10.1022/cne.24341. [Epub ahead of print]
Key words: calcitonin, afferent, neurons, cochlea

1. Gillary G, Heydt RV, Niebur E. Short-term depression and transient memory in sensory cortex.
J. Comput. Neurosci. 2017 Oct 13. doi: 10.1007/s10827-017-0662-8. [Epub ahead of print].
Key words: memory, sensory, cortex

2. Ko HK, von der Heydt R. Figure-ground Organization in the visual cortex: does meaning matter?
J Neurophysiol. 2017 Oct 4:jn.00131.2017. doi: 10.1152/jn.00131.2017. [Epub ahead of print].
Key words: figure, ground, organization

3. Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ. Enhanced stem cell differentiation and immunopurification of genome engineered human retinal ganglion cells.
Stem Cells Transl Med. 2017 Oct 10. doi: 10.1002/sctm.17-0059. [Epub ahead of print].
Key words: immunopurification, human, retinal, ganglion, cells

4. Tward DJ, Sicat CS, Brown T, Bakker A, Gallagher M, Albert M, Miller M. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.
Alzheimers Dement (Amst). 2017 Sep 14; 9:41-50. doi:10.1016/j.dadm.2017.07.005. eCollection 2017.
Key words: entorhinal, longitudinal, diffeomorphometry

5. Vadaele Y, Pribut HJ, Janak PH. Lever insertion as a salient stimulus promoting insensitivity to outcome devaluation. Front Integr Neurosci. 2017 Sep 27;11:23. doi: 10.3389/fnint.2017.00023. eCollection 2017.
Key words: salient, stimulus, devaluation

1. Antony BJ, Kim BJ, Lang A, Carass A, Prince JL, Zack DJ. Automated segmentation of mouse OCT volumes (ASiMOV): validation & clinical study of a light damage model. PLoS One. 2017 Aug 17;12(8):e0181059. doi: 10.1371/journal.pone.018159. eCollection 2017.
Key words: automated segmentation, validation & clinical

2. Hu B, Niebur E. A recurrent neural model for proto-object based contour integration and figure-ground segregation. J Comput Neurosci. 2017 Sep 19. doi: 10.1007/s10827-017-0659-3. [Epub ahead of print].
Key words: neural model, proto-object, based contour integration

3. Jeong S, Yang DS, Hong YG, Mitchell SP, Kolodkin AL. Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila. Proc Natl Acad Sci U S A. 2017 Sep 11. pii: 201713010. doi: 10.1073/pnas.1713010114. [Epub ahead of print]
Key words: semaphoring-1a reverse signaling, Drosophila

4. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease. J Neurosci. 2017 Sep 13;37(37):9037-9053. doi: 10.1523/JNEUROSCI.0811-17.2017. Epub 2017 Aug 17.
Key words: excitability, amyotrophic, lateral sclerosis, corticospinal

5. Kwon SE, Tsytsarev V, Erzurumlu RS, O'Connor DH. Organization of orientation-specific Whisker deflection responses in layer 2/3 of mouse somatosensory cortex. Neuroscience. 2017 Aug 4. pii: S0306-4522(1)30553-5. doi: 10.1016/j.neuroscience.2017.07.067. [Epub ahead of print]
Key words: orientation, somatosensory, cortex

6. Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham JR, Pachinis V, Hattar S, Song J, Brown SP, Blackshaw S. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature. 2017 Aug 31;548(7669):582-587. doi: 10.1038/nature23663. Epub 2017 Aug 23.
Key words: Lhx6, GABA, Sleep

7. Statton MA, Vazquez A, Morton SM, Vasudevan EVL, Bastian AJ. Making sense of cerebellar contribution to perceptual and motor adaptation. Cerebellum. 2017 Aug 24. doi: 10.1007/s12311-017-0879-0.
Key words: cerebellar, contribution, motor adaption

8. Turkiew E, Falconer D, Reed N, Höke A. Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy. J Peripher Nerv Syst. 2017 Sep;22(3): 162-171. doi: 10.1111/jns.12219.
Key words: Sarm1, neuroprotective, peripheral neuropathy

1. Cho C, Smallwood PM, Nathans J. Reck and Gpr124 are essential receptor cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation. Neuron. 2017 Aug 30;95(5):1221-1225.
Key words: Reck, Gpr124, Wnt7a/Wnt7b, angiogenesis

2. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease. J Neurosci. 2017 Aug 17. pii: 0811-17. doi: 10.1523/JNEUROSCI.0811-17.2017. [Epub ahead of print]
Key words: excitability, amyotrophic, lateral, sclerosis, corticospinal

3. Millan EZ, Kim HA, Janak PH. Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior. Neuroscience. 2017 Jul 28;360:106-117. doi:10.1016/j.neuroscience.2017.07.044. [Epub ahead of print]
Key words: optogentic, activation, amygdala, alcohol, consummatory

1. De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, Zhang HY, Liu QR, Shen H, Xi ZX, Goldman D, Bonci A. Local cues establish and maintain region-specific phenotypes of basal ganglia microglia. Neuron. 2017 Jul 19;95(2):341-356.e6. doi: 10.1016/j.neuron.2017.06.020. Epub 2017 Jul 6.
Key words: basal ganglia, microglia

2. Fraser KM, Janak PH. Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking. Eur J Neurosci. 2017 Jul 12. doi:10.1111/enj.13642. [Epub ahead of print]
Key words: dopamine, dorsal lateral striatum

3. Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.
Key words: ALS, C9orf72

4. Miller SJ, Rothstein JD. 3D printer generated tissue iMolds for cleared tissue using single- and multi-microscopy for deep tissue evaluation. Biol Proced Online. 2017 Jul 5;19-7. doi: 10.1186/s12575-017-0057-2. eCollection 2017.
Key words: 3D printer; CLARITY; Cleared tissue; Medicine; Microscopy; Tissue molds

5. Vasavda C, Zaccor NW, Scherer PC, Sumner CJ, Snyder SH. Measuring G-protein-coupled receptor signaling via radio-labeled GTP binding. J Vis Exp. 2017 Jun 9;(124). doi: 10.3791/55561.
Key words: protein-coupled receptor, GTP binding

6. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. Synergistic signaling by light and acetylcholine in mouse iris sphincter muscle. Curr Biol. 2017 Jun 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.
Key words: light, acetylcholine, iris sphincter

7. Ye Z, Goutman JD, Pyott SJ, Glowatzki E. MGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea. J Physiol. 2017 Jun 1;595(11):3483-3495. doi: 10.1113/JP272604.
Key words: mGluR1, inner hair cells, cochlea

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Essential Information for Human Subjects Research Teams Related to COVID-19
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Managing Investigational Product Returns from Research Participants
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Changes in HSR Recertification
Update on Insurance and Research Participant Financial Responsibility Information Sheet: Signature No Longer Required
Change in JHM IRB Review Fees for Commercially-Funded Studies
Data and Safety Monitoring Board Training Manual Now Available
Good Clinical Practice (GCP) Fundamentals: Understanding and Applying GCP to Human Subject Research
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Clinical Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
COVID-19 Funding Opportunities
Searle Scholars Program
Michael J. Fox Foundation (MJFF) Challenge
Updated Guidance from NIH on COVID-19 Flexibilities for Applicants and Recipients
COVID-19 and Research Updates
Townhall Thursdays - Providing a Pulse on What's Happening in Research at JHU
New System to Request Outgoing Subawards
Point of Contact for NIH Loan Repayment Program
JHU SOM Update on NIH Policy on Foreign Involvement
Disclosure of Payments from Foreign Educational Institutions and Government Agencies
Institutional Letter of Support Required for Institutional Training Grant Applications
Notice to the Johns Hopkins Community Regarding the National Science Foundation Grant Reporting Requirement for Harassment Findings and Actions
Prohibited Mention of Prior Review for New Replacement Applications
NIH Policy on Foreign Component Involvement
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants

This Month's Departmental Listings

Upcoming Deadlines for July and September

Updates and Events at the Genetics Research Core Facilities


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