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June 2020

Biophysics and Biophysical Chemistry Archives

1. Lawson MR, Berger JM. Tuning the sequence specificity of a transcription terminator.
Curr Genet. 2019 Feb 9. doi: 10.1007/s00294-019-00939-1. [Epub ahead of print] Review.
Key words: Hexameric helicase; Molecular motors; NusG; Rho; Spt5; Transcription; Translation

2. Matyszewski M, Zheng W, Lueck J, Antiochos B, Egelman EH, Sohn J. Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly. J Biol Chem. 2018 Dec 28;293(52):20240-20248. doi: 10.1074/jbc.RA118.006050. Epub 2018 Nov 1.
Key words: Monte Carlo simulation; NLRC4; biophysics; caspase; cryo-electron microscopy; inflammasome; innate immunity; nod-like receptor (NLR); pyroptosis

3. Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB. Getting the most out of your crystals: data collection at the new high-flux, microfocus MX beamlines at NSLS-II. Molecules. 2019 Jan 30;24(3). pii: E496. doi: 10.3390/molecules24030496.
Key words: CDP-Chase; NSLS-II; PHM; PI3K?, Akt1; microdiffraction; microfocus; multicrystal; nonhomogeneous crystals; vector data collection

4. Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C. FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics. Elife. 2019 Jan 25;8. pii: e40988. doi: 10.7554/eLife.40988.
Key words: DNA replication; S. cerevisiae; biochemistry; chemical biology; chromosomes; deubiquitinating enzyme; gene expression; histone chaperone; nucleosome dynamics; transcription; ubiquitin

5. Schlierf M, Wang G, Chen XS, Ha T. Hexameric helicase G40P unwinds DNA in single base pair steps.
Elife. 2019 Jan 28;8. pii: e42001. doi: 10.7554/eLife.42001.
Key words: DnaB; DnaG; G40P; molecular biophysics; none; single-molecule FRET; structural biology

6. Wied TJ, Chin AC, Lau AY. High conformational variability in the GluK2 Kainate receptor ligand-binding domain. Structure. 2019 Jan 2;27(1):189-195.e2. doi: 10.1016/j.str.2018.09.008.
Key words: free energy calculations; glutamate receptors; kainate receptors; ligand binding; molecular dynamics simulations; small-angle X-ray scattering

7. Worden EJ, Hoffmann NA, Hicks CW, Wolberger C. Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L. Cell. 2019 Feb 8. pii: S0092-8674(19)30151-5. doi: 10.1016/j.cell.2019.02.002. [Epub ahead of print]
Key words: Dot1L; chromatin; cryo-EM; histones; methylation; nucleosome; structural biology; ubiquitin

1. Yu A, Lau A. Glutamate and glycine binding to the NMDA receptor. Structure. 2018 Jul 3;26(7):1035-1043.e2.
Key words: NMDA receptors; free energy calculations; glutamate receptors; ligand binding; molecular dynamic simulations

1. Parker MW, Botchan MR, Berger JM. Mechanisms and regulation of DNA replication initiation in eukaryotes. Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144.
Key words: DNA replication, Helicase, Loader, AAA+, ATPase, CMG; Cdc6; Cdt1; DNA replication; MCM2-7; ORC; helicase; initiator

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June 2020 articles:
Essential Information for Human Subjects Research Teams Related to COVID-19
Coronavirus Research Billing Notices and FAQ
Research Billing Buzz eNewsletter
Managing Investigational Product Returns from Research Participants
Update to Organization Policy on Registration of Clinical Trials
Changes in HSR Recertification
Update on Insurance and Research Participant Financial Responsibility Information Sheet: Signature No Longer Required
Change in JHM IRB Review Fees for Commercially-Funded Studies
Data and Safety Monitoring Board Training Manual Now Available
Good Clinical Practice (GCP) Fundamentals: Understanding and Applying GCP to Human Subject Research
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Clinical Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
COVID-19 Funding Opportunities
National Science Foundation (NSF) Partnerships for Innovation (PFI) Program
1907 Trailblazer Award
Michael J. Fox Foundation (MJFF) Challenge
Updated Guidance from NIH on COVID-19 Flexibilities for Applicants and Recipients
COVID-19 and Research Updates
Townhall Thursdays - Providing a Pulse on What's Happening in Research at JHU
New System to Request Outgoing Subawards
Point of Contact for NIH Loan Repayment Program
JHU SOM Update on NIH Policy on Foreign Involvement
Disclosure of Payments from Foreign Educational Institutions and Government Agencies
Institutional Letter of Support Required for Institutional Training Grant Applications
Notice to the Johns Hopkins Community Regarding the National Science Foundation Grant Reporting Requirement for Harassment Findings and Actions
Prohibited Mention of Prior Review for New Replacement Applications
NIH Policy on Foreign Component Involvement
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants

This Month's Departmental Listings

Upcoming Deadlines for June and July

Temporary Closures and Updates at the Genetics Research Core Facilities



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