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Research

Johns Hopkins’ sleep research seeks to better understand the relationship between sleep and cognition in health and disease. Our clinical trials explore the role of normal and disordered sleep at various stages of the life cycle and the impact of disease on sleep, including arthritis and HIV infection. Investigations also cover the influence of sleep on waking experience and the biological and behavioral impact of sleep disruption.

Johns Hopkins Center for Interdisciplinary Sleep Research and Education

Johns Hopkins Bayview Medical Center
301 Building
5501 Hopkins Bayview Circle
Baltimore, MD 21224

The Johns Hopkins Center for Interdisciplinary Sleep Research and Education is a program that applies the expertise and resources of sleep specialists and their colleagues to a range of medical disciplines in sleep research and education at Johns Hopkins, including off-site, multicentered clinical trials. 

Sleep Laboratories

  • Alan Schwartz Lab

    Work in the Alan Schwartz Lab primarily focuses on obesity and sleep apnea pathogenesis, nocturnal hypoxemia in COPD, and obesity and neural control in sleep-disordered breathing (SDB). We have experience exploring the mechanisms of SBD, with an emphasis on novel approaches to the detection and management of the disorder. We’ve also tested new methods to evaluate the severity of upper airway obstruction during sleep and to treat sleep apnea.

    Research Areas: critical care medicine, sleep medicine, hypoxemia, obesity, pulmonary medicine, COPD, sleep-disordered breathing, sleep apnea

    Lab Website

    Principal Investigator

    Alan Schwartz, M.D.

    Department

    Medicine

  • Deborah Schwengel Lab

    Research in the Deborah Schwengel Lab focuses on perioperative care of pediatric patients with obstructive sleep apnea as well as anesthetic care for patients undergoing ethanol embolization of vascular malformations. Our team also explores topics within graduate medical education. In this field, our work has involved evaluating both an educational curriculum and a disaster preparedness curriculum for anesthesiology residents. We also have a long-standing interest in international adoption medicine.

    Research Areas: medical education, anesthesia, perioperative, pediatrics, sleep apnea

  • Hartmut Schneider Lab

    The Hartmut Schneider Lab studies sleep medicine and respiratory physiology during sleep. Our team develops ways to diagnose and treat patients with obstructive sleep apnea and chronic obstructive pulmonary disease (COPD). Recent inventions include a disposable pneumotachometer and a device for nasal air insufflations (NI). We recently developed a way to use both sleep and nasal insufflation treatments to reduce metabolic demand in patients with cystic fibrosis, a discovery which is now being tested in a clinical trial evaluating ways to slow down pulmonary cachexia.

    Research Areas: respiratory system, sleep medicine, cystic fibrosis, obstructive sleep apnea, COPD, nasal air insufflations

    Principal Investigator

    Hartmut Schneider

    Department

    Medicine

  • Naresh Punjabi Lab

    The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

    Research Areas: epidemiology, type 2 diabetes, insulin resistance, cardiovascular diseases, sleep apnea

    Principal Investigator

    Naresh Punjabi, M.D., Ph.D.

    Department

    Medicine

  • Nicholas Dalesio Lab

    Research in the Nicholas Dalesio Lab is currently examining pre-surgical predictors of post-surgical respiratory complications in children with obstructive sleep apnea and sleep-disordered breathing; the impact of anesthesia and pharmacological agents on upper airway physiology; and techniques for pediatric airway imaging.

    Research Areas: children, respiratory system, obstructive sleep apnea, anesthesia, pediatrics, sleep disorders

  • Philip Smith Lab

    Work in the Philip Smith Lab explores several key topics within the field of sleep medicine. We investigate the role of obesity and neural control in sleep-disordered breathing as well as the impact of metabolic function on sleep apnea. We also research the ways in which HIV and its treatments impact a patient’s sleep. Our studies have included the effects of HIV and highly active antiretroviral therapy (HAART) on both sleep and daytime function as well as the relationship between systemic inflammation and sleep apnea in men with HIV.

    Research Areas: AIDS, sleep medicine, obesity, HIV, metabolic function, sleep apnea

    Principal Investigator

    Philip Smith, M.D.

    Department

    Medicine

  • Rashmi Nisha Aurora Lab

    Work in the Rashmi Nisha Aurora Lab explores topics within the field of sleep medicine, with a focus on pulmonary diseases that are disruptive to sleep and the use of polysomnography for diagnosing sleep disorders. Our recent research has included studies on home sleep testing for sleep apnea patients, the relationship between sleep-disordered breathing and caffeine consumption, and how obstructive sleep apnea impacts type 2 diabetes in older adults. We also have an interest in critical care medicine and have conducted studies on the ongoing effects of traumatic brain injuries on sleep.

    Research Areas: critical care medicine, restless leg syndrome, sleep medicine, pulmonary medicine, polysomnography, lung disease, sleep disorders, sleep apnea

    Principal Investigator

    Nisha Aurora

    Department

    Medicine

  • Sapna Kudchadkar Lab

    Work in the Sapna Kudchadkar Lab focuses on the impact of sleep disturbances on critically ill children and the impact of sleep promotion, optimizing sedation and preventing delirium in pediatric critical care patients. We're investigating the effects of critical illness on sleep-wake cycles during short- and long-term recovery using actigraphy.

    Research Areas: critical care medicine, sleep medicine, delirium, pediatric critical care medicine

  • Susheel Patil Lab

    Research in the Susheel Patil Lab focuses on the origination and development obstructive sleep apnea (OSA). Specifically, we’re interested in how obesity, adipokines and inflammation affect mechanisms that contribute to upper airway collapsibility. We’ve studied various patient groups affected by OSA, including patients who've had bariatric surgery, are HIV-infected or have non-alcoholic fatty liver disease.

    Research Areas: upper airway obstruction, pulmonary medicine, pathogenesis, sleep apnea

    Principal Investigator

    Susheel Patil, M.D., Ph.D.

    Department

    Medicine

  • Vsevolod Polotsky Lab

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia

    Principal Investigator

    Vsevolod Polotsky, M.D., Ph.D.

    Department

    Medicine