Tuesday, March 10, 2020
Modeling & Design of Glycans:
What’s new with RosettaCarbohydrate?
Jason William Labonte
Department of Chemistry, Franklin & Marshall College
& Department of Chemical & Biomolecular Engineering, Johns Hopkins School of Engineering
Pizza at 6 pm, Seminar at 6:30 pm
Johns Hopkins School of Medicine
612 Physiology Building, 725 N. Wolfe Street, Baltimore, MD 21205
PAST PERFORMANCES (Click here for 1998-2008)
February 11 (2020) "O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis" Phuoc Tran, JHU-SOM
December 9 (2019) "8th Annual Area-wide Glycobiology Poster Session"
October 8 (2019) "Glycoproteomic vignettes: O- & N-linked glycomes & cancer glycoproteomics" by Hui Zhang, Weiming Yang, Sean Ponce & Shao-Yng Chen, JHU-SOM
September 10 (2019) "Shared pathways for sialoglycan regulation of inflammation in the airway and brain" by Ron Schnaar, JHU-SOM
May 14 (2019) "Sialic acid in sickle cell disease: the quest to solve hyperhemolysis" by Samuel Merrill, JHU-SOM
April 9 (2019) "Excessive O-GlcNAcylation and Cardiomyopathy: Consequence or Cause?" by Pryia Umapathi, JHU-SOM
March 12 (2019) "Glycosylation in Malaria Parasites: Knowns and Unknowns" by Photini Sinnis, JHSPH
February 12 (2019) "Carbohydrate-Binding Antibodies: Challenges and Opportunities" Jeffrey Gildersleeve, NCI Center for Cancer Research, Frederick, MD
December 5 (2018) "7th Annual Area-wide Glycobiology Poster Session"
October 9 (2018) "Proteoglycan Sulfation Patterns and Axonal Regeneration" by Herbert Geller, NHLBI/NIH, Bethesda MD
September 11 (2018) "Glycoenzymes, Glycosylation, and Glycoengineering" Lai-Xi Wang, Qiang Yang, Chao Li, Claude (Xin) Tong, and Roushu Zhang, University of Maryland, College Park, MD
May 8 (2018) "Nutrient regulation of signaling and transcription by O-GlcNAc" by Gerald Hart, JHU-SOM
April 10 (2018) "Characterizing glycans in glycoproteins by NMR spectroscopy" Darón Freedberg, FDA/CBER, Bethesda, MD
March 13 (2018) "Role of prion protein sialylation in prion diseases" by Ilia Baskakov, Univ of Maryland Sch of Med
February 13 (2018) "Glycoengineering in CHO: Working Inside and Out" by Michael Betenbaugh and Qiong Wang, Johns Hopkins University
December 5 (2017) "6th Annual Area-wide Glycobiology Poster Session"
October 10 (2017) "Catalytic antibodies targeting glycans and glycoproteins in infection and immunity" by Maggie Wear, JHSPH
September 12 (2017) "Stressed Cells Crave Carbs too!" Natasha Zachara, JHU-SOM
April 18 (2017) "Acute increase in O-GlcNAc improves survival in mice with LPS-induced endotoxemia" by Rita Tostes, University of Sao Paulo, Sao Paulo, Brazil
January 10 (2017) "Comprehensive analysis of protein glycosylation by mass spectrometry" by Hui Zhang, David Clark, Punit Shah and Joseph Mertz, JHU-SOM
December 13 (2016) ""Deck the Peptidoglycan" - Metabolic carbohydrate probes for bacterial cell wall remodeling" by Catherine Leimkuhler Grimes, University of Delaware
October 11 (2016) "Galectins as pattern recognition receptors: First barrier or Trojan horse?" by Kelsey Abernathy, Chiguang Feng, and Gerardo Vasta, Univ of Maryland Sch of Med
September 13 (2016) "Glycoengineering Strategies to Treat Pancreatic and Brain Cancer" Kevin Yarema, Christopher Saeui, and Sagar Shah, Johns Hopkins University
May 10 (2016) "5th Annual Area-wide Glycobiology Poster Session"
April 12 (2016) "A 'Little Sugar' goes a long way" by John Hanover, Laboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD
March 8 (2016) "Siglec-8, Siglec-9 & glycans that control human lung inflammation" by Ron Schnaar, Steve Fernandes, Anabel Gonzalez-Gil, & Ryan Porell, Dept. of Pharmacology, JHU-SOM
January 12 (2016) "Bacterial Polysaccharide Vaccines" by C. Allen Bush, University of Maryland Baltimore County
November 10 (2015) "Galectin-3 and cancer: Basic to translational" Hafiz Ahmed, Glycomantra
September 8 (2015) "Capsular polysaccharide biosynthesis: A tale of two transferases" by Willie Vann & Shonoi Ming, Laboratory of Bacterial Polysaccharides CBER/FDA, Bethesda, MD
May 14 (2015) "4th Annual Area-wide Glycobiology Poster Session"
April (2015) "Glycosphingolipids: a new culprit in atherosclerotic heart disease" by Subroto Chatterjee & Sumita Mishra, Dept. of Pediatrics, JHU-SOM
March 10 (2015) "Hydrogen bonding and structure in glycans" by Daron Freedberg, FDA/CBER, Bethesda, MD
February 10 (2015) "RosettaCarbohydrate: Expanding the computational tools available to glycoscientists" Jason Labonte, Johns Hopkins University
January 13 (2015) "Cross-Species Transplantation: Improved Control of Coagulation Dysregulation for Lung and Liver" by Agnes Azimzadeh, Department of Surgery, Univ of Maryland Sch of Med
December 9 (2014) "Serindipity in Glycobiology" Yuan Chuan Lee, Johns Hopkins University
October 14, (2014) "Glycosylation and Cancer: A Driver of Disease Progression or Achilles’ Heel?" by Mohit Mathew, Christopher Saeui and Kevin Yarema, Dept. of Biomedical Engineering, Johns Hopkins University
September 9 (2014) "Protein O-glycosylation in developmentally regulated secretion" by Kelley Ten Hagen, Developmental Glycobiology Section, NIDCR/NIH
May 16 (2014) "3rd Annual Area-wide Glycobiology Poster Session"
April 8 (2014) "Development of a glycoconjugate vaccine for cholera using squaric acid chemistry" by Peng Xu and Paul Kovac,NIH, NIDDK, Bethesda, MD
March 25 (2014) "Antigenic glycopeptides: Conformational impact of protein glycosylation and disease-relevant antigenic structure " by Shin-Ichiro Nishimura, Hokkaido University, Sapporo, Japan
March 11 (2014) "Glycoengineering for improved antibody therapy and HIV vaccine design" by Lai-Xi Wang, Mohammed Amin, John Giddens, and Joseph Lomino, University of Maryland School of Medicine
February 11 (2014) "The effects of calcium on the three-dimensional structure of sialic acid oligomers" by Daron Freedberg, FDA/CBER, Bethesda, MD
January 14 (2014) "CD24: A sweet double life in immunology and cancer biology" by Yang Liu, Children’s National Medical Center, Washington, DC
October 8 (2013) "Structural & functional analyses of protein glycosylation by mass spectrometry" by Hui Zhang, Shadi Toghi Eshghi, Weiming Yang & Paul Aiyetanatasha, Department of Pathology, JHU-SOM
September 10 (2013) "O-GlcNAc and OGT: Enzymatic and Non-Enzymatic Regulation of Survival Signaling" by Natasha Zachara, JHU-SOM
May 14 (2013) "2nd Annual Area-wide Glycobiology Poster Session"
April 9 (2013) "Chemical tools to study the activation of the intracellular innate immune protein Nod2" by Catherine Grimes, University of Delaware, Newark, DE
March 12 (2013) "Integrating engineering and biology in cancer research" by Konstantinos Konstantopoulos, Johns Hopkins University
January 8 (2013) "Affinity proteomics strategies to target carbohydrate-dependent host-pathogen interactions & Analytical platforms for native glycan arrays" by John Cipollo, Center for Biologics Evaluation & Research, US FDA, Bethesda, MD,
December 11 (2012) "Raising the Roof: Mechanisms by which tumor-associated lipids suppress innate immunity" by Tonya Webb, University of Maryland School of Medicine
October 9 (2012) "LID-PEG, Harnessing sugars to fight asthma and COPD" by Ron Schnaar, Department of Pharmacology and Molecular Science, JHU-SOM
September 11 (2012) "Metabolic Glycoengineering: New Opportunities and Old Mysteries" by the Kevin Yarema Group, Johns Hopkins University
May 8 (2012) "1st Annual Area-wide Glycobiology Poster Session"
April 17 (2012) "Adhesion is an important regulator of stem cell metabolism" by Roselle Abraham, Department of Medicine, JHU-SOM
March 13 (2012) "Bacterial polysaccharide assembly and its application to vaccine synthesis" by Willie F. Vann & Pumtiwitt McCarthy, CBER/FDA, Bethesda, MD
February 7 (2012) "O-GlcNAc cycling: A systems biology approach" by John Hanover, Laboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD
January 10 (2012) "Defining and Exploiting the Cell-Environment Interface" by Jennifer Van Eyk, Department of Medicine, JHU-SOM
December 13 (2011) "Artificial cells: new technology for the production of vaccines against bacterial pathogens" by Philip R. DeShong, Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland
October 11 (2011) "The role of glycan antigens in the immunobiology of schistosomiasis" by Anthony Kwame Nyame, University of Maryland Eastern Shore, Princess Anne, MD
September 13 (2011) "NMR Studies of Polysaccharides ON and OFF cells" by Daron Freedberg, FDA, Rockville, MD
May 10 (2011) "Lactosylceramide synthase: where Glycobiology meets Atherosclerosis" by Subroto Chatterjee, Department of Pediatrics, JHU-SOM
April 12 (2011) "Lipoplex delivery of ManNAc and sialic acid to rescue hyposialylation in a mouse model of HIBM" by Marjan Huizing & Tal Yardeni, NHGRI, NIH, Bethesda, MD
March 8 (2011) "Structures and functions of cyanobacterial lectins and their effects on viral entry" by Carole Bewley, NIDDK, NIH, Bethesda, MD
February 8 (2011) "What we know that we do not know about malaria glycobiology (and what we intend to do about it)" by Rhoel R. Dinglasan, JHU-SPH
January 18 (2011) "Systems Glycobiology from the Glycome to the Genome" by Pauline Rudd, Dublin-Oxford NIBRT, Dublin, Ireland
December 14 (2010) "Sialic Acid Modulation of the Innate Immune Response" by Alan S. Cross, Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine
Oct. 12 (2010) "Glycoproteins Made to Order. From Synthetic Chemistry to Glycobiology" by Lai-Xi Wang, Mohammed Amin, Jared Orwenyo, and Wei Huang, Inst. of Human Virology, Univ. of MD.
Sept. 14 (2010) "Extensive crosstalk between O-GlcNAcylation & phosphorylation in nearly every cell process – Why???" by Gerald Hart, Dept. Biological Chemistry, JHU-SOM
May 11 (2010) "N-Glycosylation of E Cadherin Regulates Intercellular Adhesion" by Mihai Nita-Lazar, University of Maryland School of Medicine
April 13 (2010) "Glycoproteomics and Glycomics: A New Paradigm for Molecular Analysis of Disease Progression" by Hui Zhang, Yuan Tian, & Yan Li, Dept. of Pathology, JHU-SOM
March 9 (2010) "Design of Neoglycoprotein Arrays and Application to Cancer Vaccine Research" by Jeff Gildersleeve, Chemical Biology Lab, Center for Cancer Research, NCI, Frederick
Jan. 12 (2010) "GLUCOSAMINE: Inspiring New Treatments for Osteoarthritis and Cartilage Tissue Engineering" by Jennifer Elisseeff, Matthew Gibson & Jeanniene Coburn, Dept. Biomed. Eng., JHU
Dec. 8 (2009) "Structure/Activity Studies of APF: A Glycopeptide Antiproliferative Factor from Interstitial Cystitis Patients" by Joseph Barchi, NCI, Frederick, MD
Oct. 13 (2009) "O-GlcNAc, a Novel Regulator of the Cellular Stress Response and Cell Survival" by Natasha Zachara, Dept. Biological Chemistry, JHU-SOM
Sept 8 (2009) "Structure-function studies on galactosyltransferases and their use in bioconjugation - a progress report" by Pradman K. Qasba, Structural Glycobiology Section, NCI – Frederick
May 12 (2009) "Biosynthesis and functions of sialic acids" by The Schnaar Lab, Dept. of Pharmacol. & Mol. Sci., JHU-SOM
April 14 (2009) "Chemoenzymatic synthesis of glycoproteins for functional studies" by Lai-Xi Wang, Institute of Human Virology, Univ. of Md.
March 5 (2009) "GlycoBlotting: PCR for Glycobiology?" by Shin Nishimura, Hokkaido Univ., Sapporo, Japan
Feb 10 (2009) "Sugar-based drug discovery by modulating gene expression: The hexosamine platform" by Kevin Yarema, Dept. Biomed. Eng., JHU
Jan 13 (2009) "The Road to AvioGlycomics and Beyond" by Y.C. Lee, Biol. Dept., JHU.