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  • Berger Lab

    Lab Website
    Principal Investigator:
    James Berger, Ph.D.
    Biophysics and Biophysical Chemistry

    The Berger Lab's research is focused on understanding how multi-subunit assemblies use ATP for ...overcoming topological challenges within the chromosome and controlling the flow of genetic information. A long-term goal is to develop mechanistic models that explain in atomic level detail how macromolecular machines transduce chemical energy into force and motion, and to determine how cells exploit and control these complexes and their activities for initiating DNA replication, shaping chromosome superstructure and executing myriad other essential nucleic-acid transactions.

    Our principal approaches include a blend of structural (X-ray crystallography, single-particle EM, SAXS) and solution biochemical methods to define the architecture, function, evolution and regulation of biological complexes. We also have extensive interests in mechanistic enzymology and the study of small-molecule inhibitors of therapeutic potential, the development of chemical approaches to trapping weak protein/protein and protein/nucleic acid interactions, and in using microfluidics and single-molecule approaches for biochemical investigations of protein dynamics.
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    Research Areas: biochemistry, proteomics, ATP, DNA, genomics
  • Jungsan Sohn

    Lab Website
    Principal Investigator:
    Jungsan Sohn, Ph.D.
    Biophysics and Biophysical Chemistry

    Dr. Sohn's lab is interested in understanding how biological stress-sensors are assembled, dete...ct danger signals and initiate stress response.

    Innate immunity is the first line of defense against invading pathogens in higher eukaryotes. We are using in vitro quantitative biochemical assays and mutagenesis and x-ray crystallography to investigate the underlying operating principles of inflammasomes, a component of the innate immune system, to better understand biological stress sensors.
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    Research Areas: immunology, cell biology, cancer, eukaryotes, stress sensors
  • Michael A. Jacobs Lab

    Lab Website

    The Jacobs lab is within the Division of Cancer Imaging Research in the Department of Radiology... and Radiological Science. The lab translates radiological imaging (MRI/PET/CT) from research to the clinical setting. The Jacobs lab is establishing the use of multi-parametric/multinuclear/modality imaging to monitor treatment response in different cancers and co-developed a new metric for DWI/ADC mapping to discern treatment response. They are developing and implementing a new method for diagnosis of cancer using machine and deep learning to measure different types of lesions. The Jacobs lab is also developing novel segmentation of radiological images using non-linear dimensionality reduction. In addition, we are investigating methods to integrate Radiomics and Informatics and prognostic markers for disease. Other research areas include diagnostic medical physics and novel computer science applications. The medical physics research includes MRI quality assessments, X-ray, fluoroscopy, ultrasound and applications to therapeutic medical physics. We are developing a residency using the Commission on Accreditation of Medical Physics Education Program in Diagnostic Medical Physics. view more

    Research Areas: treatment response, PET/CT, prostate, cancer, metastasis, pancreatic disease, liver diseases, cancer imaging
  • Ryuya Fukunaga Lab

    The Fukunaga Lab uses multidisciplinary approaches to understand the cell biology, biogenesis a...nd function of small silencing RNAs from the atomic to the organismal level.

    The lab studies how small silencing RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs), are produced and how they function. Mutations in the small RNA genes or in the genes involved in the RNA pathways cause many diseases, including cancers. We use a combination of biochemistry, biophysics, fly genetics, cell culture, X-ray crystallography and next-generation sequencing to answer fundamental biological questions and also potentially lead to therapeutic applications to human diseases.
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    Research Areas: biophysics, biochemistry, cell biology, cell culture, genomics, RNA
  • Wolberger Lab

    Lab Website
    Principal Investigator:
    Cynthia Wolberger, Ph.D.
    Biophysics and Biophysical Chemistry

    The Wolberger Lab is interested in the structural and mechanistic basis for transcriptional reg...ulation and ubiquitin signaling as it relates to the integrity and expression of the genome. We use x-ray crystallography, enzymology, cell-based assays and a variety of biophysical tools to gain insights into the mechanisms underlying these essential cellular processes. view more

    Research Areas: biophysics, ubiquitin signaling, genomics, transcriptional regulation
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