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• Ahmet Gurakar Lab

  The Ahmet Gurakar Lab is interested in bioartificial liver dialysis systems and the application of total plasma exchange in the treatment of liver disorders.

  Research Areas: transplants, viral hepatitis, liver diseases, plasma exchange

  

  Principal Investigator

  Ahmet Gurakar, M.D.

  Department

  Medicine
  

• Balagopal Lab - Viral Hepatitis and Translational Virology

  The Balagopal Lab has adapted high-resolution tools to study viruses in situ. Specifically, we were the first to quantify hepatitis C virus (HCV) infection in single hepatocytes by developing single-cell laser capture microdissection (scLCM) and integrating this tool with highly sensitive quantitative real-time PCR. We reported that HCV infects a minority of hepatocytes that are found in geospatial clusters. More recently, we (PIs Balagopal and Thio) integrated scLCM with droplet digital PCR (ddPCR) to reveal the first observations of hepatitis B virus (HBV) infection at single cell resolution in the liver. We found that HBV infects nearly all hepatocytes prior to antiviral therapy. However, during antiviral therapy, HBV infection is diminished while viral transcription is markedly attenuated.
  
  Our lab has also focused on HIV-1 infection and immune activation for over a decade. Most recently, we have studied type 1 interferon responses to HIV-1 using RNA sequencing (RNAseq). Using th...is technology, we identified novel interferon-stimulated genes (ISGs) that are associated with HIV-1 restriction in vivo. view more

  Research Areas: HIV-1, hepatitis B, hepatitis C

  

  Principal Investigator

  Ashwin Balagopal, M.D.

  Department

  Medicine
  

• Mark Sulkowski Lab

  Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

  Research Areas: infectious disease, hepatitis B, hepatitis C

  Lab Website

  

  Principal Investigator

  Mark Sulkowski, M.D.

  Department

  Medicine
  

• Saleh Alqahtani Lab

  The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver disease and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients.

  Research Areas: fatty liver disease, Hepatitis, liver transplants, cirrhosis, liver diseases, liver cancer

  

  Principal Investigator

  Saleh Alqahtani, M.B.Ch.B., M.S.

  Department

  Medicine
  

• Stuart C. Ray Lab

  Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and an increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV.

  Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology

  Lab Website

  

  Principal Investigator

  Stuart Ray, M.D.

  Department

  Medicine
  

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