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Research Lab Results for vestibular

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  • Agrawal Lab

    Lab Website

    The Agrawal Lab is focused on the medical and surgical treatment of otologic and neurotologic c...onditions. Research is focused on the vestibular system (the inner ear balance system), and how the function of the vestibular system changes with aging. Particular focus is given to study how age-related changes in vestibular function influence mobility disability and fall risk in older individuals. view more

    Research Areas: cognition, visuospatial ability, vertigo, aging, balance, vestibular system
  • Carey Research Group

    John Carey’s Research Group conducts research regarding diseases of the inner ear that affect b...oth balance and hearing mechanisms. Key interests include superior semicircular canal dehiscence syndrome (SCDS), the normal vestibular reflexes and how they change with age, novel intratympanic treatments (i.e., middle ear injections) for conditions like Menière’s disease and sudden hearing loss, and the mechanisms of vestibular migraine. With Lloyd Minor, Dr. Carey helped develop the operation to repair the superior canal in patients with SCDS using image-guided surgery. Dr. Carey has been funded by the National Institutes of Health – National Institute on Deafness and Other Communication Disorders to study inner ear balance function in Menière’s disease and steroid treatment of sudden hearing loss. view more

    Research Areas: meniere's disease, vertigo, audiology, neurotology/otology, superior canal dehiscence, cochlear implant, hearing loss
  • John Carey Lab

    The John Carey Lab studies inner ear balance function in Menière’s disease and steroid treatmen...t of sudden hearing loss. Other research of interest includes the normal vestibular reflexes and how they change with age, the ototoxic effects of gentamicin, the use of intratympanic steroids for Menière’s disease, the diagnostic utility of vestibular evoked myogenic potential testing, and the mechanisms of vestibular migraine. view more

    Research Areas: vestibular migraine, otolaryngology, intratympanic steroids, meniere's disease, balance, hearing loss
  • Kathleen Cullen Lab

    Lab Website

    We are continually in motion. This self-motion is sensed by the vestibular system, which contri...butes to an impressive range of brain functions, from the most automatic reflexes to spatial perception and motor coordination. The objective of Dr. Cullen's lab's research program is to understand the mechanisms by which self-motion (vestibular) information is encoded and then integrated with signals from other modalities to ensure accurate perception and control of gaze and posture. Our studies investigate the sensorimotor transformations required for the control of movement, by tracing the coding of vestibular stimuli from peripheral afferents, to behaviorally-contingent responses in central pathways, to the readout of accurate perception and behavior. Our experimental approach is multidisciplinary and includes a combination of behavioral, neurophysiological and computational approaches in alert behaving non-human primates and mice. Funding for the laboratory has been and is provided by the Canadian Institutes for Health Research (CIHR), The National Institutes of Health (NIH), the National Sciences and Engineering Research Council of Canada (NSERC), FQRNT / FQRSC (Quebec). view more

    Research Areas: otolaryngology, biomedical engineering, surgery, neuroscience
  • Laboratory of Vestibular NeuroAdaptation

    The Laboratory of Vestibular NeuroAdaptation investigates mechanisms of gaze stability in peopl...e with loss of vestibular sensation. A bulk of our research investigates motor learning in the vestibulo-ocular reflex (VOR) using different types of error signals. In addition, we investigate the synergistic relationship between the vestibular and saccadic oculomotor systems as trainable strategies for gaze stability. We are particularly interested in developing novel technologies to assess and deliver improved rehabilitation outcomes. We are validating a hand-held computer tablet for assessment of sensorimotor function and participating in a clinical trial comparing traditional vestibular rehabilitation against a device developed in our laboratory that can unilaterally or bilaterally strengthen the VOR.

    Members of the lab include physical therapists, physicians, engineers, statisticians and post-doctoral fellows. The laboratory is supported by generous grant funding from NASA, the NIH, the DOD and grateful patients
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    Research Areas: gaze stability, vestibular sensation, vestibulo-ocular reflex, rehabilitation, sensorimotor functions
  • Machine Biointerface Lab

    Lab Website

    Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medic...al Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.

    Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.

    Medical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
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    Research Areas: medical instruments, bioelectricities, neuroengineering, nerve stimulation
  • Neuro-Vestibular and Ocular Motor Laboratory

    Principal Investigator:
    Amir Kheradmand, M.D.
    Neurology

    In our laboratory we study the brain mechanisms of eye movements and spatial orientation.

    -H...ow magnetic stimulation through transcranial devices affects cortical brain regions
    -Neural mechanisms underlying balance, spatial orientation and eye movement
    -Mathematical models that describe the function of ocular motor systems and perception of spatial orientation
    -Short- and long-term adaptive processes underlying compensation for disease and functional recovery in patients with ocular motor, vestibular and perceptual dysfunction
    Developing and testing novel diagnostic tools, treatments, and rehabilitative strategies for patients with ocular motor, vestibular and spatial dysfunction
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    Research Areas: perception of spatial orientation, ocular motor physiology
  • Ocular Motor Physiology Laboratory

    Lab Website

    Our research is directed toward how the brain controls the movements of the eyes (including eye... movements induced by head motion) using studies in normal human beings, patients and experimental animals. The focus is on mechanisms underlying adaptive ocular motor control. More specifically, what are mechanisms by which the brain learns to cope with the changes associated with normal development and aging as well as the damage associated with disease and trauma? How does the brain keep its eye movement reflexes properly calibrated? Our research strategy is to make accurate, quantitative measures of eye movements in response to precisely controlled stimuli and then use the analytical techniques of the control systems engineer to interpret the findings.

    Research areas: 1) learning and compensation for vestibular disturbances that occur either within the labyrinth or more centrally within the brain, 2) the mechanisms by which the brain maintains correct alignment of the eyes to prevent diplopia and strabismus, and 3) the role of ocular proprioception in localizing objects in space for accurate eye-hand coordination.
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    Research Areas: diplopia, Labyrinth, eye movement, strabismus, vestibular
  • Sensorimotor Adaptation - Vestibular and Oculomotor

    Research in the Sensorimotor Adaptation--Vestibular and Oculomotor group focuses on sensorimoto...r adaptation to space flight and fractal statistics in physiology. Our projects aim to understand sensory processing for motor control with an emphasis on adaptive capabilities and mathematical modeling. view more

    Research Areas: sensorimotor adaptation, physiology, space flight, fractal statistics
  • Vestibular NeuroEngineering Lab

    Lab Website

    Research in the Vestibular NeuroEngineering Lab (VNEL) focuses on restoring inner ear function ...through “bionic” electrical stimulation, inner ear gene therapy, and enhancing the central nervous system’s ability to learn ways to use sensory input from a damaged inner ear. VNEL research involves basic and applied neurophysiology, biomedical engineering, clinical investigation and population-based epidemiologic studies. We employ techniques including single-unit electrophysiologic recording; histologic examination; 3-D video-oculography and magnetic scleral search coil measurements of eye movements; microCT; micro MRI; and finite element analysis. Our research subjects include computer models, circuits, animals and humans. For more information about VNEL, click here.
    VNEL is currently recruiting subjects for two first-in-human clinical trials:
    1) The MVI Multichannel Vestibular Implant Trial involves implantation of a “bionic” inner ear stimulator intended to partially restore sensation of head movement. Without that sensation, the brain’s image- and posture-stabilizing reflexes fail, so affected individuals suffer difficulty with blurry vision, unsteady walking, chronic dizziness, mental fogginess and a high risk of falling. Based on designs developed and tested successfully in animals over the past the past 15 years at VNEL, the system used in this trial is very similar to a cochlear implant (in fact, future versions could include cochlear electrodes for use in patients who also have hearing loss). Instead of a microphone and cochlear electrodes, it uses gyroscopes to sense head movement, and its electrodes are implanted in the vestibular labyrinth. For more information on the MVI trial, click here.
    2) The CGF166 Inner Ear Gene Therapy Trial involves inner ear injection of a genetically engineered DNA sequence intended to restore hearing and balance sensation by creating new sensory cells (called “hair cells”). Performed at VNEL with the support of Novartis and through a collaboration with the University of Kansas and Columbia University, this is the world’s first trial of inner ear gene therapy in human subjects. Individuals with severe or profound hearing loss in both ears are invited to participate. For more information on the CGF166 trial, click here.
    view more

    Research Areas: neuroengineering, audiology, multichannel vestibular prosthesis, balance disorders, balance, vestibular, prosthetics, cochlea, vestibular implant
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