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Research Lab Results for vascular

Displaying 21 to 26 of 26 results
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  • Peter Abadir Lab

    Principal Investigator:
    Peter Abadir, M.D.
    Medicine

    Research in the Peter Abadir Lab focuses on the renin-angiotensin system (RAS), a signaling pathway that regulates blood pressure and has been linked independently to both aging and inflammation. We’re particularly interested in changes in RAS that occur with aging. We also study signal transduction and the role of the crosstalk between angiotensin II receptor in aging and are interested in understanding the function of angiotensin II in the process of vascular aging.

    Research Areas: renin-angiotensin system, aging, inflammation, gerontology
  • Rachel Damico Lab

    Principal Investigator:
    Rachel Damico, M.D., Ph.D.
    Medicine

    Work in the Rachel Damico Lab explores topics within the fields of vascular biology and pulmonary medicine, with a focus on acute lung injury and apoptosis in lung diseases. Our studies have included examining idiopathic and scleroderma-associated pulmonary arterial hypertension, vascular receptor autoantibodies, and the link between inflammation and the Warburg phenomenon in patients with pulmonary arterial hypertension. We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis.

    Research Areas: critical care medicine, acute lung injury, lung disease, vascular biology, apoptosis
  • Rasika Mathias Lab

    Principal Investigator:
    Rasika Mathias, Sc.D.
    Medicine

    Research in the Rasika Mathias Lab focuses on the genetics of asthma in people of African ancestry. Our work led to the first genomewide association study of its kind in 2009. Currently, we are analyzing the whole-genome sequence of more than 1,000 people of African ancestry from the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA). CAAPA’s goal is to use whole-genome sequencing to expand our understanding of how genetic variants affect asthma risk in populations of African ancestry and to provide a public catalog of genetic variation for the scientific community. We’re also involved in the study of coronary artery disease though the GeneSTAR Program, which aims to identify mechanisms of atherogenic vascular diseases and attendant comorbidities.

    Research Areas: heart disease, African Americans, asthma, genomics, health disparities
  • Richard Rivers Lab

    Lab Website

    The Richard Rivers Lab researches vascular communication with a focus on microcirculation physiology. Our team seeks to determine how metabolic demands are passed between tissue and the vascular network as well as along the vascular network itself. Our goal is to better understand processes of diseases such as cancer and diabetes, which could lead to the development of more targeted drugs and treatment. We are also working to determine the role for inwardly rectifying potassium channels (Kir) 2.1 and 6.1 in signaling along the vessel wall as well as the role of gap junctions.

    Research Areas: cancer, potassium, diabetes, vascular biology, vascular, microcirculation
  • Robert Fitzgerald Laboratory

    Principal Investigator:
    Robert Fitzgerald, Ph.D.
    Medicine

    The Robert Fitzgerald Laboratory studies cardiopulmonary physiology, especially cardiopulmonary control. We have focused in particular on the operation of the carotid body and the role of acetylcholine in its functioning. We have also examined the reflex effects of carotid body stimulation in various organs as well as the reflex response of ACTH and adrenal cortical hormones to hypoxic peripheral arterial chemoreceptor stimulation. We are currently interested in the spleen, as it is the only organ other than the lung that demonstrates increased vascular resistance in response to local hypoxia.

    Research Areas: acetylcholine, carotid body, cardiopulmonary diseases, lung disease, hypoxia
  • Vascular Neurology Lab

    Lab Website
    Principal Investigator:
    Rafael Tamargo, M.D.
    Neurology
    Neurosurgery

    Vascular research led by Rafael Tamargo, M.D., the Walter E. Dandy Professor of Neurosurgery, explores treatment of aneurysms, arteriovenous malformations, cavernous malformations, and arteriovenous fistulas of the brain and spinal cord. Basic science research has focused on endothelial cell-leukocyte interactions (inflammation) after subarachnoid hemorrhage and identifying drugs that might inhibit this inflammatory response as well as the narrowing of blood vessels.

    Research Areas: aneurysm, stroke
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