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Research Lab Results for vaccines

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  • Andrea Cox Lab

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a... focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design. view more

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells
  • Anna Durbin Lab

    Lab Website

    The Anna Durbin Lab evaluates experimental vaccines through human clinical trials. We have cond...ucted both pediatric and adult clinical trials on vaccines for HIV, hepatitis C, HPV, influenza, malaria, dengue virus, rotavirus and other viruses. We also have a longstanding interest in better understanding the immunologic factors of dengue infection and disease. We’re working to identify the viral, host and immunologic factors that cause severe dengue illness. view more

    Research Areas: dengue fever, epidemiology, international health, vaccines, HPV, clinical trials, HIV, malaria, hepatitis C, flu
  • Arturo Casadevall Lab

    The Arturo Casadevall Lab uses a multidisciplinary approach to explore two key topics within mi...crobiology and immunology: how microbes cause disease and how hosts can protect themselves against those microbes. Much of our research focuses on the fungus Cryptococcus neoformans, which frequently causes lung infections in people with impaired immunity. We also work with the microorganism Bacillus anthracis, a bacterium that causes anthrax and is frequently used in biological warfare. Our goal is to devise antibody-based countermeasures to protect against this and other similar threats. view more

    Research Areas: microbiology, immunology, vaccines, cryptococcus neoformans, tuberculosis
  • Best Laboratory

    Principal Investigator:
    Simon Best, M.D.
    Vein Centers

    The Best Laboratory focus on therapeutic vaccine development for HPV-related diseases by develo...ping a murine model of papilloma analogous to Recurrent Respiratory Papillomatosis (RRP) for testing of DNA vaccine technology. We also work to understand the immunosuppressive tumor microenvironment that facilitates RRP development, and translate this work into novel therapies and clinical practice. view more

    Research Areas: Recurrent Respiratory Papillomatosis, HPV-related diseases, vaccines, Laryngeal papillomas, otolaryngology, papillomas, DNA vaccine technologies
  • Cervical Cancer Research Lab

    Lab Website

    Johns Hopkins is a member of the Specialized Program of Research Excellence (SPORE) in Cervical... Cancer. With a $11.5 million grant from the National Cancer Institute, we are conducting lab, translational and clinical studies to prevent and treat cervical cancers. Previous studies have identified connections between immune system genes and HPV16. Current projects include the development of next-generation HPV vaccines to control HPV-associated precursor lesions and invasive cancer. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: HPV vaccines, cervical cancer, HPV
  • Cervical Dysplasia Research Lab

    Lab Website

    We are interested in how immune responses occur in the cervix. The focus of our translational ...research is on developing immune therapies for disease caused by human papillomavirus (HPV). HPV infection causes more cancers than any other virus in the world. Cervical cancer is the most common cancer caused by HPV, and although we have known how to screen for it for over half a century, it remains the second most common cause of cancer death in women. Although the preventive vaccines are a public health milestone, they prevent HPV infections, but are not designed to make immune responses to treat HPV. We are testing different strategies to make immune responses that could treat HPV disease. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: cervical cancer, HPV, cancer vaccines
  • David Sack Lab

    Research in the David Sack Lab focuses on enteric infections. Our team has worked to develop la...boratory detection methods to better understand the epidemiology of these agents. We also work to create appropriate clinical management strategies, such as antibiotics and rehydration methods, for enteric infections. Our work has included participating in the development of vaccines for a range of bacterial infections, including rotavirus, cholera and enterotoxigenic E. coli. view more

    Research Areas: epidemiology, international health, cholera, infectious disease, diarrhea, malaria, tuberculosis
  • Diane Griffin Lab

    Research in the Diane Griffin Lab focuses on the viral, cellular and immunologic determinants o...f diseases caused by alphaviruses and the measles virus. Our current studies aim to understand the immune-system mechanisms behind viral clearance and disease enhancement. Our team is also working to understand the pathogenesis of the measles virus, with a focus on developing new vaccines and learning how the virus induces immunosuppression. view more

    Research Areas: immunology, vaccines, measles, alphavirus, encephalitis
  • Drew Pardoll Lab

    The Pardoll Lab focuses on the regulation of antigen-specific T cell responses and studies appr...oaches to modify these responses for immunotherapy. Pardoll has a particular interest in cancer immunology and his lab’s studies on basic immunologic mechanisms have led to the development and design of a number of cancer vaccines and discovery of key checkpoint ligands and receptors, such as PD-L2, LAG-3 and neuritin, many of which are being targeted clinically.

    Our primary pursuits are discovering and elucidating new molecules that regulate immune responses, investigating the biology of regulatory T cells, and better understanding the specific biochemical signatures that allow a patient’s T cells to selectively target cancer cells.
    view more

    Research Areas: tumor antigens, cancer, immunotherapy, regulatory T cells, T cells
  • Ivan Borrello Lab

    Lab Website
    Principal Investigator:
    Ivan Borrello, M.D.
    Pathology

    The Ivan Borrello Lab focuses on the development of a novel approach of adoptive T cell therapy... utilizing marrow-infiltrating lymphocytes (MILs) as a more tumor-specific T cell approach. This has led to establishing the first adoptive T cell trials at Johns Hopkins and an exploration of this approach in other diseases, including nonhematologic malignancies. The lab also examines strategies for treating minimal residual disease (MRD) in myeloma with the combination of immune modulation and whole cell-based vaccines. view more

    Research Areas: immunology, vaccines, multiple myeloma, cancer, translational research, immunotherapy, T cells
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