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  • Amit Pahwa Lab

    Principal Investigator:
    Amit Pahwa, M.D.
    Medicine

    The Amit Pahwa Lab conducts research on a variety of topics within internal medicine. Our most ...recent studies have explored misanalysis of urinalysis results, urinary fractional excretion indices in the evaluation of acute kidney injury and nocturnal enuresis as a risk factor for falls in older women. We also investigate cancer diagnostics and treatments. In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium. view more

    Research Areas: acute kidney injury, cancer, internal medicine, urology
  • Bert Vogelstein Laboratory

    Lab Website
    Principal Investigator:
    Bert Vogelstein, M.D.
    Oncology

    The Bert Vogelstein Laboratory seeks to develop new approaches to the prevention or treatment o...f cancers through a better understanding of the genes and pathways underlying their pathogenesis.

    Our major focus is on cancers of the colon and rectum. We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. This expansion gives rise to a small benign colon tumor (called a polyp or adenoma). This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. As the mutations accumulate, the tumors become progressively more dangerous.

    Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management.
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    Research Areas: rectal cancer, colon cancer, genomics, pathogenesis
  • Best Laboratory

    The Best Laboratory focus on therapeutic vaccine development for HPV-related diseases by develo...ping a murine model of papilloma analogous to Recurrent Respiratory Papillomatosis (RRP) for testing of DNA vaccine technology. We also work to understand the immunosuppressive tumor microenvironment that facilitates RRP development, and translate this work into novel therapies and clinical practice. view more

    Research Areas: Recurrent Respiratory Papillomatosis, HPV-related diseases, vaccines, Laryngeal papillomas, otolaryngology, papillomas, DNA vaccine technologies
  • Brain Cancer Biology and Therapy Lab

    Lab Website
    Principal Investigator:
    Gregory Riggins, M.D., Ph.D.
    Neurosurgery

    The goal of the Johns Hopkins Brain Cancer Biology and Therapy Laboratory is to locate the gene...tic and genomic changes that lead to brain cancer. These molecular changes are evaluated for their potential as therapeutic targets and are often mutated genes, or genes that are over-expressed during the development of a brain cancer. The brain cancers that the Riggins Laboratory studies are medulloblastomas and glioblastomas. Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. Our laboratory uses large-scale genomic approaches to locate and analyze the genes that are mutated during brain cancer development. The technologies we now employ are capable of searching nearly all of a cancer genome for molecular alterations that can lead to cancer. The new molecular targets for cancer therapy are first located by large scale gene expression analysis, whole-genome scans for altered gene copy number and high throughput sequence analysis of cancer genomes. The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. view more

    Research Areas: brain cancer
  • Brain Tumor Cancer Genetics Lab

    Lab Website

    The lab explores the genetic underpinnings that drive the pathogenesis of a variety of primary ...central nervous system neoplasms. We are interested in exploiting genetic changes for both diagnostic and therapeutic purposes. Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. view more

    Research Areas: brain tumor genetics, brain tumor
  • Brain Tumor Laboratory

    Lab Website
    Principal Investigator:
    Henry Brem, M.D.
    Neurology
    Neurosurgery

    At the brain tumor laboratory, Henry Brem, M.D. and Betty Tyler, along with more than 350 train...ees, have conducted scientific research, contributed to scientific literature, amended clinical practice, and illuminated new pathways for improving clinical outcomes.



    The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors.
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    Research Areas: brain tumor drug delivery, brain tumor
  • Brennen Lab

    Principal Investigator:
    W. Nathaniel Brennen, Ph.D.
    Oncology

    The Brennen laboratory takes a rigorous, multi-disciplinary, team-based approach towards develo...ping innovative therapeutic and prognostic strategies for prostate cancer with an emphasis on exploiting vulnerabilities within the tumor microenvironment towards this goal. To accomplish this goal, we are strategically pursuing novel therapeutic platforms, including stromal-targeted prodrugs, protoxins, and radiolabeled antibodies, in addition to cell-based therapy and drug delivery; all of which are designed to reduce toxicity to peripheral non-target tissue (i.e. side effects) while maximizing anti-tumor efficacy (i.e. therapeutic benefit). Currently, many of these strategies are focused on overcoming stromal barriers to anti-tumor immune responses such that men suffering from prostate cancer can share in the immense, revolutionary power of immunotherapy that is transforming care for many with advanced disease in other tumor types previously thought to be unmanageable using conventional approaches. Unfortunately, prostate cancer has largely proven refractory to these powerful approaches thus far and requires novel mono- or combinatorial treatment strategies to unleash the full potential of the immune system and generate personalized anti-tumor responses with the capability of producing long-term durable responses or even cures in these men. view more

    Research Areas: prostate cancer, prodrugs, cell-based therapy, tumor microenvironment
  • Cervical Cancer Research Lab

    Lab Website

    Johns Hopkins is a member of the Specialized Program of Research Excellence (SPORE) in Cervical... Cancer. With a $11.5 million grant from the National Cancer Institute, we are conducting lab, translational and clinical studies to prevent and treat cervical cancers. Previous studies have identified connections between immune system genes and HPV16. Current projects include the development of next-generation HPV vaccines to control HPV-associated precursor lesions and invasive cancer. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: HPV vaccines, cervical cancer, HPV
  • Cervical Dysplasia Research Lab

    Lab Website

    We are interested in how immune responses occur in the cervix. The focus of our translational ...research is on developing immune therapies for disease caused by human papillomavirus (HPV). HPV infection causes more cancers than any other virus in the world. Cervical cancer is the most common cancer caused by HPV, and although we have known how to screen for it for over half a century, it remains the second most common cause of cancer death in women. Although the preventive vaccines are a public health milestone, they prevent HPV infections, but are not designed to make immune responses to treat HPV. We are testing different strategies to make immune responses that could treat HPV disease. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: cervical cancer, HPV, cancer vaccines
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