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Research Lab Results for translational research

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  • Pulmonary Infection and Inflammation Research Lab

    Principal Investigator:
    Hongpeng Jia, M.D., M.Sc.
    Surgery

    The Jia lab performs basic and translational research into the mechanisms of and therapeutic st...rategy for viral and bacterial infection-induced inflammatory lung diseases, one of the leading causes of death in pulmonary diseases, especially for the ongoing pandemic of the SARS-CoV-2 mediated COVID-19. Our work has identified novel roles of Angiotensin-converting enzyme 2 (ACE2) in the inflammatory response to viral and bacterial lung infection and its complex contributions into the pathogenesis and disease progression and outcome of COVID-19. In seeking to translate these findings to clinical studies, we have been working on a collaboration with other investigators, developing novel diagnostic, preventive, and therapeutic tools in combating the devastating COVID-19, even in the era of effective vaccine prevention. These studies are funded by NIAID. view more

    Research Areas: RAS, viral and bacterial lung infection, inflammatory lung disease
  • Spinal Column Biomechanics Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Biomechanics Laboratory focuses on the study of various spinal pathologies. T...he Biomechanics Laboratory studies a wide array of tools and techniques in order to advance spinal surgery for the benefit of patients. With a team of researchers, engineers, and neurosurgeons, the Biomechanics Laboratory participates in the newest developments in applied and translational research. Our facility alongside the International Center for Orthopaedic Advancement at the Johns Hopkins Bayview Medical Center serves as a premiere learning institute. The laboratory not only conducts novel biomechanical studies but also functions as a teaching facility for neurosurgical trainees interested in mastering highly specialized or technical procedures.The Spinal Column Biomechanics Laboratory specializes in applied mechanics, force vector analysis, spinal instrumentation testing and development of novel spinal reconstructions. view more

    Research Areas: spine
  • Supendymoma and Ependymoma Research Center

    Lab Website
    Principal Investigator:
    Henry Brem, M.D.
    Neurosurgery

    The Johns Hopkins comprehensive Subependymoma and Ependymoma Research Center divideS its effort...s into three areas: basic science, translational research and clinical practice. Each division works separately but shares findings and resources openly with each other and our collaborators. The goal of our united efforts is to optimize current treatments to affect the care received by patients with subependymomas and ependymomas. Also, our clinical, translational and basic science teams work to develop novel therapies to improve and extend the lives of those with these rare tumors. view more

    Research Areas: brain cancer
  • The Cohen Lab

    Principal Investigator:
    Keira Cohen, M.D.
    Medicine

    Combining microbiology and bioinformatics, the Cohen Lab conducts translational research on myc...obacteria. By application of advanced genomic techniques to the problems of tuberculosis and nontuberculous mycobacteria, the Cohen Lab aims to develop improved tools for the diagnosis and management of mycobacterial disease. view more

    Research Areas: nontuberculous mycobacteria, genomics, drug resistance, tuberculosis
  • Yukari Manabe Lab

    Principal Investigator:
    Yuka Manabe, M.D.
    Medicine

    Investigators in the Yukari Manabe Lab evaluate the accuracy of rapid, point-of-care diagnostic...s for HIV, tuberculosis and related infectious diseases in resource-limited settings particularly sub-Saharan Africa and examine the impact of diagnostic interventions on disease detection and patient outcomes. The team also conducts operational and translational research in tuberculosis and HIV co-infection. view more

    Research Areas: Africa, infectious disease, AIDS, HIV, point-of-care diagnostics, resource limitations, tuberculosis
  • Zsuzsanna McMahan Lab

    Lab Website
    Principal Investigator:
    Zsuzsanna McMahan, M.D., M.H.S.
    Medicine

    The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel anti...gens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented. view more

    Research Areas: gastrointestinal system, rheumatology, biomarkers, scleroderma, antigens, mycophenolate mofetil
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