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The Phenotyping Core promotes functional genomics and other preclinical translational science at Johns Hopkins. We assist and collaborate in the characterization and use of genetically and phenotypically relevant animal models of disease and gene function.
Dr. Anders’ laboratory focuses on the basic processes that lead to cancer. His team approaches these questions through the use of both experimental models and examination of human tissues. His team is specifically interested in interrogating the immune microenvironment of cancer, detecting circulating cancer cells and preventing cancer metastasis.
Work in the Sivanesan Neuromodulation Laboratory (SNL) focuses on developing electrical stimulation therapies for treating neuropathic pain conditions and discovering novel applications for patients suffering from painful conditions. We study mechanisms of all modalities of spinal cord stimulation in the laboratory and aim to rapidly translate these discoveries to patient care. This bench to bedside approach facilitates a unique integration of the latest science with the clinical care of patients.
The Spinal Column Biomechanics Laboratory focuses on the study of various spinal pathologies. The Biomechanics Laboratory studies a wide array of tools and techniques in order to advance spinal surgery for the benefit of patients. With a team of researchers, engineers, and neurosurgeons, the Biomechanics Laboratory participates in the newest developments in applied and translational research. Our facility alongside the International Center for Orthopaedic Advancement at the Johns Hopkins Bayview Medical Center serves as a premiere learning institute. The laboratory not only conducts novel biomechanical studies but also functions as a teaching facility for neurosurgical trainees interested in mastering highly specialized or technical procedures.The Spinal Column Biomechanics Laboratory specializes in applied mechanics, force vector analysis, spinal instrumentation testing and development of novel spinal reconstructions.
The Johns Hopkins comprehensive Subependymoma and Ependymoma Research Center divideS its efforts into three areas: basic science, translational research and clinical practice. Each division works separately but shares findings and resources openly with each other and our collaborators. The goal of our united efforts is to optimize current treatments to affect the care received by patients with subependymomas and ependymomas. Also, our clinical, translational and basic science teams work to develop novel therapies to improve and extend the lives of those with these rare tumors.
Combining microbiology and bioinformatics, the Cohen Lab conducts translational research on mycobacteria. By application of advanced genomic techniques to the problems of tuberculosis and nontuberculous mycobacteria, the Cohen Lab aims to develop improved tools for the diagnosis and management of mycobacterial disease.
Investigators in the Yukari Manabe Lab evaluate the accuracy of rapid, point-of-care diagnostics for HIV, tuberculosis and related infectious diseases in resource-limited settings particularly sub-Saharan Africa and examine the impact of diagnostic interventions on disease detection and patient outcomes. The team also conducts operational and translational research in tuberculosis and HIV co-infection.
The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel antigens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented.
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